- Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study
- 14+ VitaminDWiki pages have ANXIETY in the title
- VitaminDWiki -
12 studies in both categories Seniors and Depression
Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study
Metabolites 2022, 12(10), 884; https://doi.org/10.3390/metabo12100884
by Evangelia Zaromytidou 1ORCID,Theocharis Koufakis 2ORCID,Georgios Dimakopoulos 3ORCID,Despina Drivakou 2,Stavroula Konstantinidou 4,Pantelitsa Rakitzi 2,Maria Grammatiki 2,Eleni Manthou 2,Athanasios Notopoulos 1,Ioannis Iakovou 5,Anna Gotzamani-Psarrakou 6 andKalliopi Kotsa 2,*Older people are prone to frailness, present poor adherence to pharmacotherapy, and often have adverse drug effects. Therefore, it is important to develop effective and safe interventions to mitigate the burden of anxiety and depression disorders in this population. The aim of this study was to investigate the effect of vitamin D supplementation on the anxiety and depression status of elderly people with prediabetes. Participants were randomly assigned a weekly dose of vitamin D3 of 25,000 IU (n = 45, mean age 73.10 ± 7.16 years) or nothing (n = 45, mean age 74.03 ± 7.64 years), in addition to suggested lifestyle measures. The State-Trait Anxiety Inventory subscales (STAI-T and STAI-S) and the Patient Health Questionnaire-9 (PHQ-9) were used to evaluate anxiety and depression levels, respectively, at baseline, 6, and 12 months.
A total of- 92.68% of the participants in the vitamin D group and
- 97.14% of the controls exhibited vitamin D deficiency (<20 ng/mL) at baseline.
Mean STAI-T scores were lower in supplemented individuals than in the control group at 6 (38.02 ± 9.03 vs. 43.91 ± 7.18, p = 0.003) and 12 months (32.35 ± 7.77 vs. 44.97 ± 7.78, p < 0.001). The same pattern was evident for STAI-S scores at 6 (37.11 ± 7.88 vs. 43.20 ± 9.33, p = 0.003) and 12 months (32.59 ± 6.45 vs. 44.60 ± 9.53, p < 0.001). Supplemented participants demonstrated lower mean PHQ-9 scores compared to controls at 6 (15.69 ± 6.15 vs. 19.77 ± 8.96, p = 0.021) and 12 months (13.52 ± 5.01 vs. 20.20 ± 8.67, p < 0.001). Participants with deficiency and insufficiency at baseline experienced equal benefits of supplementation in terms of anxiety and depression scores.
In conclusion, in a high-risk population, a weekly vitamin D supplementation scheme was effective in alleviating anxiety and depression symptoms. More studies are needed to elucidate the relevant mechanisms.
14+ VitaminDWiki pages have ANXIETY in the title
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Items found: 14
VitaminDWiki -
12 studies in both categories Seniors and Depression This list is automatically updated
- Elderly with low vitamin D were depressed, anxious, or stressed (Saudi Arabia) – March 2024
- Depression in seniors greatly reduced by Vitamin D (e.g. 50,000 IU) – meta-analysis June 2023
- Frailty 2X less likely in depressed seniors having a good level of vitamin D – Nov 2018
- Centenarians with good vitamin D were 1.5 X less likely to depressed – Aug 2018
- Less depression in seniors taking enough Omega-3 – meta-analysis July 2018
- Senior Depression and Vitamin D – review March 2016
- Mood disorders 11X worse for older adults with low vitamin D – 2006
- Many articles on Senior depression - 35 percent with less than 10 ng – Sept 2010
- Elderly men lacking vitamin D tend to be depressed – Sept 2010
- Depressed people had less than 10 ng of vitamin D – July 2010
- Senior women with less than 20 ng vitamin D were 2X more likely to become depressed May 2010
- Table of outcomes for seniors vs vitamin D level
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