Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease
Journal of Medicinal Food Vol. 21, No. 9 Review, https://doi.org/10.1089/jmf.2017.0130
Alice Barros Câmara, Iara Dantas de Souza, and Rodrigo Juliani Siqueira Dalmolin
Study includes details of Vitamin D control of proteins associated with Alzheimer's
- Vitamin D reduces Alzheimer’s disease in at least 11 ways – Jan 2013
- Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
- Alzheimer’s disease 21 percent more likely if low vitamin D – meta-analysis Aug 2015
- Cognition of Alzheimer’s patients improved by daily 4,000 IU of vitamin D – RCT Jan 2015
- The End of Alzheimer's and Dementia if adjust Vitamin D, B-12, Iron, Omega-3, etc.
Alzheimer's and Vitamin D genes
- Alzheimer’s associated with Vitamin D and Vitamin D receptor – video and pdf – Aug 2018
- Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
Alzheimer's and Omega-3 (study does not mention Omega-3)
- Hypothesis: Omega-3 reduces Alzheimer’s directly and via the gut – Sept 2018
- If struggling with mental health you may need Omega-3, Vitamin D. Iron, Probiotics, etc. – US News Sept 2018
- Brain is helped by Omega-3 during all phases of life – Aug 2018
- Improve Cognitive Health and Memory with Vitamin D and Omega-3 – World Patent March 2018
- Why Alzheimer’s studies using Omega-3 have mixed results – quality, dose size, Omega-6, genes, etc. March 2018
- Omega-3 found to treat Alzheimer’s and Parkinson’s in animals – Sept 2017
- Alzheimer’s (apoE4) may require more than Omega-3 - May 2017
Alzheimer's and Food (study does not mention Food)
- Alzheimer’s increase due to less sun or more meat
- The Startling Link Between Sugar and Alzheimer's
- Alzheimer's disease – less risk if smarter, higher vitamin D, better genes or less coffee – Dec 2017
Overview Alzheimer's-Cognition and Vitamin D has the following summary
- FACT: Cognitive decline is 19X more likely if low vitamin D
- FACT: Dementia is associated with low vitamin D levels.
- FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
- FACT: Dementia is associated with low vitamin D - many studies
- FACT: Alzheimer's Disease is 4X less likely if high vitamin D
- FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
- FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
- OBSERVATION: Reports of increased vitamin D levels result in improved cognition
- OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
- OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
- OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
- OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
- OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
- OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
- OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
- OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
- OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
- OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org
- OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence
- OBSERVATION: End of Alzheimer's videos, transcripts and many studies protocol has been very successful
- It adjusts Vitamin D, B-12, Iron, Omega-3, food, etc, and can now be done at home.
- FACT: Vitamin D is extremely low cost and has very very few side effects
- CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
- PREDICTION MET: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
There are 13+ Alzheimer’s meta-analyses in VitaminDWiki
There are 97+ Alzheimer’s studies in VitaminDWiki
Dementia is associated with low vitamin D - many studies 50+ studies
16+ studies in both categories Cognitive and Omega-3
PDF is available free at Sci-Hub 10.1089/jmf.2017.0130
Chart for life expectancy >75 years (90 countries)
Alz death rate per 100,000 total population
Probably even larger differences if adjust for use of air conditioning (which keeps people out of the sun)
Comment by Founder of VitaminDWiki
Many ways that Vitamin D can protect against Alzheimer's
Vitamin D (VD) deficiency is a growing problem, affecting a significant portion of the population in many countries. VD deficiency may be related to several diseases, including Alzheimer's disease (AD). This study aimed to review the relationship between VD deficiency and AD. We describe the proteins involved in AD pathogenesis and how those proteins can be influenced by VD deficiency. We also investigated a relationship between AD death rate and solar radiation and we found an increased AD death rate in countries with low sunlight. It was also observed that amyloid precursor protein, ryanodine receptor, mammalian target of rapamycin complex 1, and receptor for advanced glycation end products are associated with a worse prognosis in AD. While the Klotho protein, phosphatase and tensin homologue, and VD receptor are associated with a better prognosis in the disease. The literature suggests that decline in VD concentrations may be involved in the establishment and progression of AD. According to sunlight data, we can conclude that countries with low average sunlight have high AD death rate.