Ageing faster and more knee pain are associated with low vitamin D – March 2022

Accelerated Epigenetic Aging Mediates the Association between Vitamin D Levels and Knee Pain in Community-Dwelling Individuals

The journal of nutrition, health & aging (2022) https://doi.org/10.1007/s12603-022-1758-z
L. J. Strath, L. Meng, A. Rani, P. Sinha, A. J. Johnson, Z. Huo, T. C. Foster, J. D. Edburg, R. B. Fillingim & Yenisel Cruz-Almeida

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Objectives
To examine the relationship between Vitamin D status and pain intensity and disability in individuals with and without knee pain, and to examine the role of epigenetics in this relationship.

Design
Cross-sectional analysis of data from the UPLOAD-2 study (Understanding Pain and Limitations in OsteoArthritic Disease-2).

Participants
189 individuals aged 45–65 years and older.

Measurements
Serum Vitamin D levels, pain related interference and characteristic pain intensity measures, and the epigenetic clock GrimAge derived from blood analyses.

Results
Lower Vitamin D was associated with advanced epigenetic aging (AgeAccelGrim), greater pain and disability and that (AgeAccelGrim) mediated the relationship between Vitamin D status and self-reported pain (ab = -0.0799; CI [-0.1492, -0.0237]) and disability (ab = -0.0669; CI [-0.1365, -0.0149]) outcomes.

Conclusion
These data support the notion that lifestyle factors such as nutrition status play a key role in aging process, as well as the development and maintenance of age-related diseases such as pain. Modifying nutrition status could help promote healthy aging and reduce pain.
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VitaminDWiki - Osteoarthritis pages with KNEE in title (29 as of March 2022)

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Items found: 30
Title Modified
Knee osteoarthritis pain reduced by 4,000 IU of Vitamin D for 3 months (35 ng avg.) – Dec 2022 26 Dec, 2022
Ageing faster and more knee pain are associated with low vitamin D – March 2022 08 Mar, 2022
I needed more than Vitamin D to treat my knee osteoarthritis 06 Nov, 2021
Knee osteoarthritis helped by Low Level Laser Therapy 02 Nov, 2020
Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020 21 Oct, 2020
Total knee arthroplasty – worse outcome if low vitamin D – 2016, 17, 18, 2019 02 Apr, 2019
Less Knee Osteoarthritis if take more Vitamin D – 8 MRI confirmations – Nov 2018 10 Oct, 2018
Knee Osteoarthritis benefited by 20 ng of Vitamin D for 5 years – RCT July 2018 10 Jul, 2018
If You Tear a Knee Ligament, Arthritis Is Likely to Follow in 10 Years (both are related to low Vitamin D) – Nov 2017 08 Nov, 2017
More pain after knee surgery if low vitamin D – Oct 2015 26 Aug, 2017
Knee osteoarthritis helped by vitamin D2 (40,000 IU weekly raised 57 % above 30 ng) June 2017 29 Jul, 2017
Knee Osteoarthritis (Radiographic ) 3X less if have lots of Magnesium – May 2015 29 Jul, 2017
Reduced knee osteoarthritis if consistently supplement with vitamin D for 2 years – April 2017 29 Jul, 2017
Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015 20 Jul, 2017
Knee osteoarthritis not helped by Vitamin D (when you ignore vitamin D levels) – April 2017 25 Apr, 2017
Knee osteoarthritis strongly associated with low Boron – 2015 24 Mar, 2017
Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013 24 Dec, 2016
Synovitis (knee osteoarthritis) associated with low vitamin D – Dec 2016 21 Dec, 2016
Vitamin D increasing muscle strength may reduce knee pain – Feb 2016 22 Nov, 2016
Hypothesis- Knee osteoarthritis is reduced by vitamin D increasing level of nitric oxide – Dec 2013 06 Oct, 2016
Good evidence for knee osteoarthritis and vitamin D, unsure of other OA – Review March 2013 06 Oct, 2016
Knee osteoarthritis reduced somewhat by 50,000 IU vitamin D monthly (need more) – RCT Aug 2015 08 Mar, 2016
Knee pain in seniors predicted by low vitamin D 5 years before – Feb 2014 27 Oct, 2015
Knee joint space narrowing (Osteoarthritis) 1.5X worse with low vitamin D – meta-analysis Sept 2015 03 Oct, 2015
Will knee osteoarthritis be prevented with 1700 IU of vitamin D – proposed RCT 08 Aug, 2015
Knee osteoarthritis more painful if low vitamin D, especially among obese – Jan 2015 12 Apr, 2015
Knee Osteoarthritis 3.2X more likely to get worse if low Vitamin D and high PTH – Dec 2014 23 Feb, 2015
Knee osteoarthritis 2.3 X more likely to get worse if low level of vitamin D – Dec 2014 07 Oct, 2014
Probability of knee osteoarthritis up 50 percent if 20 ng less vitamin D – Nov 2011 10 Nov, 2012
Knee osteoarthritis associated with low vitamin D for those under age 55 – Dec 2010 10 Nov, 2012

VitaminDWiki pages with EPIGENETICS in title

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Items found: 16

VitaminDWiki pages - Meta-analysis and Pain

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