Impact of 3-Monthly Vitamin D Supplementation Plus Exercise on Survival after Surgery for Osteoporotic Hip Fracture in Adult Patients over 50 Years: A Pragmatic Randomized, Partially Blinded, Controlled Trial.
J Nutr Health Aging. 2017;21(4):413-420. doi: 10.1007/s12603-016-0773-3
Laiz A alaiz@santpau.cat, Malouf J, Marin A, Longobardi V, de Caso J, Farrerons J, Casademont J.
Exercise + 3 mg of calcifediol once every 90 days after elderly hip fracture
After 4 treatments (1 year) the death rates were 1 in 3 vs 1 in 14
Calcifediol = calcidiol =25-hydroxycholecalciferol =25-hydroxyvitamin D =25(OH)D
VitaminDWiki speculates that they used calcidiol because
- Less concern about compliance - 90 days instead of every 17 days or daily
- Eliminated concern about the elderly liver not being able to process vitamin D
Note: calcifediol is considered to be 5X more potent than Vitamin D
So 3 mg calcifediol = 15,000 IU every 90 days = 5,000 every 30 days = not much
See also VitaminDWiki
- 3.5 X higher risk of death 2 years after hip fracture surgery if low vitamin D – Jan 2020
- Hip fracture 58 percent more likely if low vitamin D – meta-analysis March 2017
Vitamin D can reduce the chance of getting the hip fracture
Magnesium, etc helps bone healing as well - Overview Fractures and vitamin D
- 68+ pages with hip tracture in title as of Dec 2022
- Vitamin D and fractures – 24 meta-analyses and counting – Dec 2014
- Hospital found that Vitamin D saves money by improving bone fracture healing– March 2016
Download the PDF from Sci-Hub via VitaminDWiki
OBJECTIVE:
To determine whether 3-monthly supplementation of an oral vitamin D widely used in Spain (calcifediol) plus daily exercise could influence survival at one and four years after surgery for osteoporotic hip fracture.
DESIGN:
A pragmatic, randomized, partially single-blind placebo-controlled study.
SETTING:
Patients admitted to a tertiary university hospital for acute hip fracture.
PARTICIPANTS:
675 healthy adult patients undergoing surgery for osteoporotic hip fracture were recruited from January 2004 to December 2007.
INTERVENTION:
Patients were randomized to receive either 3-monthly oral doses of 3 mg calcifediol (Hidroferol Choque®) or placebo in the 12 months postsurgery. Patients who received calcifediol were also given an exercise programme. The placebo group received standard health recommendations only.
MEASUREMENTS:
The primary endpoint was survival at 1 year and at 4 year follow-up. We also recorded new fractures, medical complications and anti-osteoporotic treatment compliance.
RESULTS:
We included a total of 88 patients, aged 62 to 99 years. Mean age was 82 years and 88.6% were women. At 12 months, 10 (11.3%) patients had died, 9 of them, from the non-intervention group. At 4 years after surgery, 20 (22.7%) had died, 3 (3.4%) from the intervention group and 17 (19.3%) from the non-intervention group. At this time, survival curve analysis showed 93% survival in the intervention group and 62% in the non-intervention group (p=0.001). At 12-month follow up, there were 18 new fractures, 9 in each group. The non-intervention group had more medical complications, with significant differences at visit 2 (p = 0.04) and 3 (p = 0.02) but not at visit 4 (p = 0.18). No significant differences between groups were found regarding treatment compliance.
CONCLUSION:
3-monthly, oral supplements of 3 mg calcifediol plus daily exercise improved survival at one-year and four-year follow up after surgery for an osteoporotic hip fracture.