Routine Postoperative Administration Of Vitamin D And Calcium After Total Thyroidectomy: A Meta-Analysis
Alvaro Sanabria PhDCorresponding Author Contact Information, a, E-mail The Corresponding Author, Luis C. Dominguez MSca, Valentin Vega MSca, Camilo Osorio MDa and Daniel Duarte MDa
aDepartment of Surgery. School of Medicine. Universidad de La Sabana. Bogota, Colombia
International Journal of Surgery
Received 14 July 2010; accepted 15 August 2010. Available online 30 August 2010.
Presented at the World Congress of Thyroid Cancer. Toronto, Canada. August 9, 2009
Background Temporary hypocalcemia is a frequent complication after total thyroidectomy. Routine postoperative administration of vitamin D and calcium can reduce the incidence of symptomatic postoperative hypocalcemia. We undertook a systematic review to assess the effectiveness of this intervention.
Methods We identified randomized controlled trials comparing the administration of vitamin D or metabolites to oral calcium or no treatment in patients after total thyroidectomy in MEDLINE, EMBASE and LILACS databases.
Results Four studies with 706 patients were included: 346 in the calcitriol group, 288 in the oral calcium group and 72 in the control group. The rates of hypocalcemia symptoms were 4%, 19% and 31%, respectively. The OR value for the comparison between calcitriol + calcium as compared to no treatment and to exclusive calcium treatment groups was 0.32 (95% CI, 0.13– 0.79) and 0.31 (95% CI, 0.14– 0.70), respectively.
Conclusion The prophylactic treatment with vitamin D or metabolites + calcium is effective to decrease the incidence of symptoms of temporary hypocalcemia.
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Suspect that if the supplements years were given years earlier that the thyroidectomy would not have been needed
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