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Preeclampsia risk reduced 60 percent if supplement with Vitamin D (they ignored dose size) – meta-analysis Sept 2017

Vitamins supplementation affects the onset of preeclampsia.

J Formos Med Assoc. 2017 Sep 3. pii: S0929-6646(17)30368-6. doi: 10.1016/j.jfma.2017.08.005. [Epub ahead of print]


Virtually all meta-analyses amazingly ignore dose sizes of Vitamin D and Calcium
Meta-analysis gives same weight to dose = 400 IU and dose = 4,000 IU
They also ignored existing levels of Vitamin D
Risk Ratio = 0.41, was NOT statistically significant.

Preeclampsia highlights

All pages listed in BOTH the categories Pregnancy and Hypertension (preeclampsia)

Healthy pregnancies need lots of vitamin D has the following summary

Vit. D
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial
Vitamin D charts from GrassrootsHealth - May 2016 has the following chart

 Download the PDF from VitaminDWiki

Fu ZM1, Ma ZZ2, Liu GJ1, Wang LL1, Guo Y3.

  • 1 Maternity Department, W.F. Maternity and Child Care Hospital, 407 Qingnian Road, Weicheng District, Weifang 261011, China.
  • 2 Pharmacy Department, Weifang People's Hospital, 151 Guangwen Street, Kuiwen District, Weifang 261041, China.
  • 3 Maternity Department, W.F. Maternity and Child Care Hospital, 407 Qingnian Road, Weicheng District, Weifang 261011, China. Electronic address: Guoywf at 163.com.

Preeclampsia may affect between 2-8% of all pregnancies. It seriously affects maternal health after pregnancy. This meta-analysis was performed to define the efficacy of vitamins supplementation on the risk of preeclampsia. Potential articles were systematically searched on the databases of Pubmed, Embase and Web of Science up to May 2016. Relative risk (RR) and 95% confidence intervals (95%CIs) were used to analyze the relationship of vitamins supplementation with risk of preeclampsia. Cochran Q test was used to test inter-study heterogeneity. Begg's funnel plot was adopted to assess the potential publication bias. 28 eligible studies were selected. Pooled results indicated that vitamins supplementation could reduce the risk of preeclampsia (RR = 0.74, 95%CI = 0.64-0.86). The studies with non-randomized controlled trial (RCT) analysis also suggested the significant relationship of vitamins supplementation with risk of preeclampsia (RR = 0.60, 95%CI = 0.42-0.85). However, negative results were observed in studies with RCT analysis. Subgroup analysis by vitamin type was performed among the studies with RCT analysis.
The results indicated that vitamin D supplementation could significantly reduce the risk of preeclampsia (RR = 0.41, 95%CI = 0.22-0.78). Similar results were observed in the studies with multivitamins supplementation (RR = 0.69, 95%CI = 0.51-0.93). Vitamins supplementation could reduce the onset of preeclampsia.

PMID: 28877853 DOI: 10.1016/j.jfma.2017.08.005

Created by admin. Last Modification: Friday September 8, 2017 11:30:04 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
8403 preeclampsia vitamins.jpg admin 08 Sep, 2017 91.67 Kb 809
8402 Preeclampsia meta-analysis.pdf admin 08 Sep, 2017 1.19 Mb 1069