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Preterm birth more likely if dark skinned and low vitamin D (not white-skinned) – April 2017

Maternal Vitamin D Insufficiency Early in Pregnancy Is Associated with Increased Risk of Preterm Birth in Ethnic Minority Women in Canada.

J Nutr. 2017 Apr 19. pii: jn241216. doi: 10.3945/jn.116.241216. [Epub ahead of print]

See also VitaminDWiki

The articles in Pregnancy AND Dark Skin are here:

Pre-term birth - many of risk factors are associated with low vitamin D

Tabatabaei N1,2, Auger N3, Herba CM1,4, Wei S1,5, Allard C6, Fink GD6,7, Fraser WD8,6,2.

  • 1 Ste-Justine University Hospital Centre and.
  • 2 Obstetrics and Gynecology, University of Sherbrooke, Sherbrooke, Quebec, Canada.
  • 3 University of Montreal Hospital Research Center, Institut National de Santé Publique du Québec, Montreal, Quebec, Canada.
  • 4 Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada.
  • 5 Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada.
  • 6 Research Centre of the Sherbrooke University Hospital (CHUS), Sherbrooke, Quebec, Canada; and.
  • 7 Departments of Biochemistry and.
  • 8 Ste-Justine University Hospital Centre and william.fraser at usherbrooke.ca.

Background: Maternal vitamin D insufficiency (plasma 25-hydroxyvitamin D [25(OH)D] <75 nmol/L) may play a role in ethnic disparities in rates of preterm and spontaneous preterm births.

Objective: We explored the relation between maternal plasma 25(OH)D concentration in the first trimester (8-14 wk of gestation) and the risk of preterm and spontaneous preterm births (<37 wk of gestation) by ethnicity.

Methods: We designed a case-control study that included 120 cases of preterm birth (<37 wk of gestation) and 360 term controls (≥37 wk of gestation) of singleton pregnancies from the 3D cohort, a multicenter study in 2456 pregnant women in Quebec, Canada. Plasma 25(OH)D was measured by LC-mass spectrometry. We compared the distribution of vitamin D status between cases and controls for 8 ethnic minority subgroups. We explored the association between maternal plasma 25(OH)D concentration and preterm and spontaneous preterm births with the use of splines in logistic regression by ethnicity.

Results: The distributions of maternal vitamin D status (<50, 50-75, and >75 nmol/L) were different in preterm and spontaneous preterm birth cases compared with controls but only in women of ethnic minority (P-trend = 0.003 and 0.024, respectively). Among ethnic subgroups, sub-Saharan Africans (P-trend = 0.030) and Arab-West Asians (P-trend = 0.045) showed an inverse relation between maternal vitamin D status and the risk of preterm birth.
Maternal plasma 25(OH)D concentrations of 30 nmol/L were associated with 4.05 times the risk of preterm birth in the total ethnic minority population (95% CI: 1.16, 14.12; P = 0.028) relative to participants with a concentration of 75 nmol/L. In contrast, there was no such association among nonethnic women (OR: 0.94; 95% CI: 0.48, 1.82; P = 0.85). There was no association when we considered only spontaneous preterm births in the total ethnic minority population (OR: 1.75; 95% CI: 0.39, 7.79; P = 0.46).

Conclusion: Vitamin D insufficiency is associated with an increased risk of preterm birth in ethnic minority women in Canada.

PMID: 28424259 DOI: 10.3945/jn.116.241216
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