Maternal Vitamin D Insufficiency Early in Pregnancy Is Associated with Increased Risk of Preterm Birth in Ethnic Minority Women in Canada.
J Nutr. 2017 Apr 19. pii: jn241216. doi: 10.3945/jn.116.241216. [Epub ahead of print]
The articles in Pregnancy AND Dark Skin are here:
- Dark-skinned people have low vitamin D (Obese pregnant women in UK in this case) – Sept 2024
- Preterm Birth 2.7X more likely if low vitamin D (dark skin in this case) - Nov 2023
- Low vitamin D while pregnant – a health emergency (Indonesia in this case) – meta-analysis May 2023
- US maternal death rate increasing (low D not mentioned) - March 2023
- Vitamin D Status May Help Explain Maternal Race and Ethnic Factors in Primary Cesarean Section Delivery – April 2020
- Dark-skin plus low vitamin D in first trimester made preterm birth 2.9 X more likely – Dec 2019
- Low vitamin D in pregnancy linked to potentially harmful vaginal bacteria in black women - May 2019
- Pregnant while black increases chance of death – mothers 3X, infants 2X (low Vitamin D) – Feb 2019
- Depressed black pregnant women should take vitamin D – April 2018
- Bone loss during black pregnancies – 4000 IU of vitamin D was not enough – Dec 2017
- Preterm birth more likely if dark skinned and low vitamin D (not white-skinned) – April 2017
- Dark skin pregnancies 2.6 times more likely to have low vitamin D – March 2017
- Premature birth and infant mortality worse if dark skin (low vitamin D) - 2015
- Autism with intellectual disability 2.5 times more likely if low vitamin D during pregnancy – April 2016
- Ethnicity and low vitamin D levels during pregnancy – Jan 2016
- Metabolites of pregnant blacks vary with vitamin D level – Nov 2014
- Dark-skined mothers: preeclampsia 12X more likely if gestational hypertension – May 2014
- 78 percent of pregnant immigrants in Sweden had less than 10 ng low vitamin D – Nov 2013
- Depression in pregnant blacks strongly associated to vitamin D levels – Nov 2012
- Dr. Holick video on vitamin D - March 2013
- Dark skinned pregnant women far from equator were very vitamin D deficient – Sept 2012
- Pregnant blacks 50 pcnt more likely to be depressed if 3 ng less vitamin D – July 2012
- 80 percent of South Asian Women in UK had less than 10 ng of vitamin D in winter – April 2012
- Blacks have more pre-term births due to low nutrients such as vitamin D – Sept 2011
- Dark skin pregnancies and Vitamin D - many studies
- Vitamin D and fertility and birth problems with dark skin – Jan 2011
- Very low vitamin D for first pregnancies and those with dark skin – Jan 2011
- 97 percent of pregnant Blacks had less than 32 ng of vitamin D - 2010
- Pregnant women vitamin D insuficiency Black 97 Hispanic 81 White 67 percent – July 2010
Pre-term birth - many of risk factors are associated with low vitamin D
- http://www.marchofdimes.org/research/vitamin-d-to-combat-preterm-birth.aspx
2X more preterm birth if black skin
Tabatabaei N1,2, Auger N3, Herba CM1,4, Wei S1,5, Allard C6, Fink GD6,7, Fraser WD8,6,2.
- 1 Ste-Justine University Hospital Centre and.
- 2 Obstetrics and Gynecology, University of Sherbrooke, Sherbrooke, Quebec, Canada.
- 3 University of Montreal Hospital Research Center, Institut National de Santé Publique du Québec, Montreal, Quebec, Canada.
- 4 Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada.
- 5 Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada.
- 6 Research Centre of the Sherbrooke University Hospital (CHUS), Sherbrooke, Quebec, Canada; and.
- 7 Departments of Biochemistry and.
- 8 Ste-Justine University Hospital Centre and william.fraser at usherbrooke.ca.
Background: Maternal vitamin D insufficiency (plasma 25-hydroxyvitamin D [25(OH)D] <75 nmol/L) may play a role in ethnic disparities in rates of preterm and spontaneous preterm births.
Objective: We explored the relation between maternal plasma 25(OH)D concentration in the first trimester (8-14 wk of gestation) and the risk of preterm and spontaneous preterm births (<37 wk of gestation) by ethnicity.
Methods: We designed a case-control study that included 120 cases of preterm birth (<37 wk of gestation) and 360 term controls (≥37 wk of gestation) of singleton pregnancies from the 3D cohort, a multicenter study in 2456 pregnant women in Quebec, Canada. Plasma 25(OH)D was measured by LC-mass spectrometry. We compared the distribution of vitamin D status between cases and controls for 8 ethnic minority subgroups. We explored the association between maternal plasma 25(OH)D concentration and preterm and spontaneous preterm births with the use of splines in logistic regression by ethnicity.
Results: The distributions of maternal vitamin D status (<50, 50-75, and >75 nmol/L) were different in preterm and spontaneous preterm birth cases compared with controls but only in women of ethnic minority (P-trend = 0.003 and 0.024, respectively). Among ethnic subgroups, sub-Saharan Africans (P-trend = 0.030) and Arab-West Asians (P-trend = 0.045) showed an inverse relation between maternal vitamin D status and the risk of preterm birth.
Maternal plasma 25(OH)D concentrations of 30 nmol/L were associated with 4.05 times the risk of preterm birth in the total ethnic minority population (95% CI: 1.16, 14.12; P = 0.028) relative to participants with a concentration of 75 nmol/L. In contrast, there was no such association among nonethnic women (OR: 0.94; 95% CI: 0.48, 1.82; P = 0.85). There was no association when we considered only spontaneous preterm births in the total ethnic minority population (OR: 1.75; 95% CI: 0.39, 7.79; P = 0.46).
Conclusion: Vitamin D insufficiency is associated with an increased risk of preterm birth in ethnic minority women in Canada.
PMID: 28424259 DOI: 10.3945/jn.116.241216
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