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Irisin (exercise hormone) increased in men by increasing sunshine and vitamin D foods – July 2016

Impact of vitamin D correction on circulating irisin: a 12 month interventional study

Int J Clin Exp Med 2016;9(7):13086-13092 www.iicem.com /ISSN:1940-5901/IJCEM0021873
Nasser M Al-Daghri1,2, Shakilur Rahman1, Shaun Sabico1, Osama E Amer1, Kaiser Wani1, Omar S Al-Attas1,2, Majed S Alokail1,2
1 Biomarkers Research Program, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia;
2 Prince Mutaib Chair for Biomarkers of Osteoporosis, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia


19% increase in Irisin over a year - probably due to increased Vitamin D level

  • Large increase in Irisin hormone by just increasing vitamin D to 20 nanograms (over a year)
  • This intervention study did not use any vitamin D supplement, just sunshine and food
  • Wonder how much increase there would have been if Vitamin D levels had gotten to 30 or 40 nanograms

See also VitaminDWiki

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"CON" exercise had 25% increase at 1 hour falling back to 18% at 6 hour
    18% is similar to that of 1 year of added Vitamin D (19%)

 Download the PDF from VitaminDWiki

Irisin, a novel myokine secreted by skeletal muscle, promotes browning of white fat and influences glucose and energy homeostasis. Irisin and vitamin D are also known for their roles in the musculoskeletal system. In this study, we examined the impact of vitamin D correction on circulating irisin in Saudi subjects. For this, vitamin D deficient subjects (<50 nmol/l) were advised to receive adequate sunlight, eat vitamin D enriched foods and retain normal physical activity for correction/improvement in vitamin D status. Seventy-eight (30 male and 48 female) subjects, who responded to vitamin D intervention, were selected for further analyses. Anthropometry and routine biochemical assay were performed. Serum 25 (OH) D was analyzed using electrochemiluminiscence. Irisin levels were analyzed at baseline and after 12-month of intervention. Serum 25 (OH) D levels were significantly increased at post-intervention compared to baseline value (51.0±4.0 vs. 27.8±2.3 in males and 69.1±4.5 vs. 27.1±1.8 in females). With an increase in the levels of vitamin D adjusted for age and BMI, a corresponding increase in irisin level was observed in males (P=0.026) and to a lesser extent in females (P=0.093). Thus, vitamin D correction had a significant impact on irisin levels in male Saudi subjects but in females it failed to reach at significance. Further studies are needed in other ethnic population to better understand the influence of vitamin D on irisin regulation and secretion.

Attached files

ID Name Comment Uploaded Size Downloads
7214 Irisin vs intensity.jpg admin 21 Oct, 2016 15:22 33.42 Kb 1221
7213 Irisin intense.PDF PDF 2015 admin 21 Oct, 2016 15:22 558.85 Kb 331
7212 Irisin.jpg admin 21 Oct, 2016 10:47 48.11 Kb 1361
7210 IRISIN 2016.pdf PDF 2016 admin 21 Oct, 2016 10:27 356.87 Kb 449
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