Poor results published Mortality reduction needs more than monthly 60,000 IU of Vitamin D - RCT Jan 2022
The D-Health Trial: A randomized trial of vitamin D for prevention of mortality and cancer
Contemporary Clinical Trials, Available online 14 April 2016, doi:10.1016/j.cct.2016.04.005
R.E. Nealea, , , B.K. Armstrongb, C. Baxtera, B. Duarte Romeroa, P. Ebelingc, D.R. Englishd, M.G. Kimline, D.S.A. McLeoda, R.L. O′Connellf, J.C. van der Polsg, A.J. Vennh, P.M. Webba, D.C. Whitemana, L. Wocknera
VitaminDWiki expects that little results will be found with 60,000 IU monthly
Elderly need at least 50,000 IU weekly, not monthly, and, one size does NOT fill all
Random Controlled trials rarely use dose sizes which vary by weight, pre-existing conditions, etc.
See also VitaminDWikii
- VITAMIN D: Public Shouldn’t Wait For Doctors To Usher In New “Golden Era” Of Preventive Medicine
- Vitamin D home fortification- don't wait 100 years for your govt
- Molecular Approaches for Optimizing Vitamin D (one size does not fit all) – Carlberg Nov 2015
13 reasons why many seniors need more vitamin D (both dose and level) - July 2023 has the following
- Senior skin produces 4X less Vitamin D for the same sun intensity
- Seniors have fewer vitamin D receptor genes as they age
Receptors are needed to get Vitamin D in blood actually into the cells - Many other Vitamin D genes decrease with age
- Since many gene activations are not detected by a blood test,
more Vitamin D is often needed, especially by seniors - Seniors are indoors more than when they were younger
not as agile, weaker muscles; frail, no longer enjoy hot temperatures - Seniors wear more clothing outdoors than when younger
Seniors also are told to fear skin cancer & wrinkles - Seniors often take various drugs which end up reducing vitamin D
Some reductions are not detected by a vitamin D test of the blood
statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc - Seniors often have one or more diseases that consume vitamin D
osteoporosis, diabetes, Multiple Sclerosis, Cancer, ... - Seniors generally put on weight as they age - and a heavier body requires more vitamin D
- Seniors often (40%) have fatty livers – which do not process vitamin D as well
- Reduced stomach acid means less Magnesium is available to get vitamin D into the cells
- Vitamin D is not as bioavailable in senior intestines
- Seniors with poorly functioning kidneys do not process vitamin D as well
- Glutathione (which increases Vitamin D getting to cells) decreases with age
Seniors category has434 items The Meta-analysis of Mortality and Vitamin D are listed here:
- Pancreatic cancer mortality 28% more likely if low vitamin D – meta-analysis Jan 2024
- COVID and Vitamin D: 2X more likely to die if low, 2X more likely to survive if supplement – umbrella meta-analysis April 2024
- Maternal pregnancy problems if Vitamin D is less than 40 ng – meta-analysis Oct 2022
- COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019
- Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019
- Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
- Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018
- Review of meta-analyses of non-skeletal benefits of vitamin D (Mortality, RTI, etc) – July 2017
- Chronic Kidney Disease mortality is 60 percent less likely if good vitamin D – meta-analysis July 2017
- Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
- ICU patients 30 % less likely to die if have enough vitamin D – meta-analysis Nov 2016
- Less likely to die if have enough vitamin D - Meta-analysis June 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014
- Vitamin D reduces risk of cause specific death, unless it is D2 – meta-analysis BMJ April 2014
- More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014
- Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014
- Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013
- Chance of dying increases by 25 percent in seniors if low vitamin D – Meta-analysis July 2013
- Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013
- Vitamin D with Calcium reduces mortality by 7 percent – meta-analysis May 2012
- Death rate reduced 8 percent for 8 nanogram more vitamin D – meta-analysis Feb 2012
- 40 ng Vitamin D perhaps optimal for reduced mortality – Meta-analysis Jan 2012
- Vitamin D3 but not D2 reduces mortality – meta-analysis July 2011
- Vitamin D and mortality a meta-analysis of RCT - 2008
The Meta-analysis of Mortality and Intervention are listed here:
- 15.3 X fewer COVID deaths in those getting Vitamin D injections in ICU – RCT July 2024
- COVID and Vitamin D: 2X more likely to die if low, 2X more likely to survive if supplement – umbrella meta-analysis April 2024
- Ventilator-associated pneumonia death rate cut in half by Vitamin D injection (300,000 IU) – RCT July 2017
- Vitamin D and Glutamine reduced Trauma Center deaths by half – Matthews March 2017
- Hospital ICU added high dose vitamin D - malpractice lawsuit costs dropped from 26 million dollars to ZERO - Oct 2016
- Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016
- ICU death rate reduced 3X when a vitamin D injection changed the PTH – Nov 2015
- Vitamin D intervention increased by 20 percent the survival of critically ill patients- RCT June 2014
- 6 percent less likely to die by taking just a little vitamin D for 3 plus years – RCT Dec 2013
- Chance of death after heart failure reduced by 1000 IU of vitamin D – Feb 2012
- Increase life expectancy by 2 years if double Vitamin D levels – Grant July 2011
Promising Vitamin D Clinical Trials - 2017 contains the followingFuture Clinical Trials- Monthly 60,000 IU of Vitamin D did not reduce mortality (too infrequent)- Feb 2022monthly) will reduce mortality – results due 2024
- Probably Fractures of the Tibia can be healed with 100,000 IU of vitamin D weekly – RCT 2023
- Severe sepsis may be prevented by 400,000 IU of vitamin D – RCT 2023
- Decalcify Aortic Valve – 3 year trial with 1 mg of Vitamin K and 5,000 IU of Vitamin D – 2021
- Multiple Sclerosis stem cell treatment (HSCT) probably not benefit from 200,000 IU of vitamin D – RCT 2020
- Delay onset of Multiple Sclerosis with 100,000 IU of vitamin D every two weeks – RCT 2020
- Vitamin D taken daily (4,000 IU) vs weekly (50,000 IU) – RCT 2019
- Critically ill children – randomized clinical trial to give single doses of up to 400,000 IU of vitamin D – 2019
- Each page includes links to similar studies/trials
- The year is shown as 1 year after trial starts, note sometimes publication does not occur until 4 years later.
- These clinical trials were selected as being likely to show good results by VitaminDWiki in 2017.
- If an item is of interest. you should consider taking Vitamin D and perhaps other supplements such as Magnesium, Omega-3, and Vitamin K rather than waiting for the results of the clinical trial to be published, or waiting several decades for your doctor to incorporate the results into his practice
See also VitaminDWiki
- Vitamin D home fortification- don't wait 100 years for your govt
- Consensus that treatment of Rickets by a single supplement took 80 years, how long for health problems needing 2 supplements – Feb 2016
- A balanced diet is no longer enough – supplements needed - VitaminDWiki Oct 2012
- VITAMIN D: Public Shouldn’t Wait For Doctors To Usher In New “Golden Era” Of Preventive Medicine
- Vitamin D trials underway are unlikely to be useful – Jan 2015 10 reasons, such as too small of dose, too short of time, dose size not vary with weight, . .
- Intervention - Vitamin D category listing has
828 items along with related searches - Vitamin D intervention -100 active clinical trials as of May 2018
- 1 pill every two weeks fights all of the following
Diabetes + Heart Failure + Chronic Pain + Depression + Autism + Breast Cancer + Colon Cancer + Prostate Cancer + BPH (prostate) + Preeclampsia + Premature Birth + Falls + Cognitive Decline + Respiratory Tract Infection + Influenza + Tuberculosis + Chronic Obstructive Pulmonary Disease + Lupus + Inflammatory Bowel Syndrome + Urinary Tract Infection + Poor Sleep + Growing Pain + Multiple Sclerosis + PMS + Schizophrenia + Endometriosis + Smoking 27 problems
Note: Once a week also fights: COVID, Headaches, Colds, Fibromyalgia, Asthma, Hives, Colitis etc.
Background:
Vitamin D, specifically serum 25(OH)D has been associated with mortality, cancer and multiple other health endpoints in observational studies, but there is a paucity of clinical trial evidence sufficient to determine the safety and effectiveness of population-wide supplementation. We have therefore launched the D-Health Trial, a randomized trial of vitamin D supplementation for prevention of mortality and cancer. Here we report the methods and describe the trial cohort.Methods:
The D-Health Trial is a randomized placebo-controlled trial, with planned intervention for 5 years and a further 5 years of passive follow-up through linkage with health and death registers. Participants aged 65–84 years were recruited from the general population of Australia. The intervention is monthly oral doses of 60,000 IU of cholecalciferol or matching placebo. The primary outcome is all-cause mortality. Secondary outcomes are total cancer incidence and colorectal cancer incidence.Results: We recruited 21,315 participants to the trial between February 2014 and May 2015. The participants in the two arms of the trial were well-balanced at baseline. Comparison with Australian population statistics shows that the trial participants were less likely to report being in fair or poor health, to be current smokers or to have diabetes than the Australian population. However, the proportion overweight or with health conditions such as arthritis and angina was similar.
Conclusions:
Observational data cannot be considered sufficient to support interventions delivered at a population level. Large-scale randomized trials such as the D-Health Trial are needed to inform public health policy and practice.Monthly 60,000 IU of Vitamin D did not reduce mortality (too infrequent)- Feb 2022monthly) will reduce mortality – results due 2024(Cached) Printer Friendly Follow this page for updates3756 visitors, last modified 11 Jan, 2022, This page is in the following categories (# of items in each category)