Relationship Between Vitamin D Levels and Depressive Symptoms in Older Residents From a National Survey Population.
Psychosom Med. 2010 Jul 1. Epub ahead of print
Stewart R, Hirani V.
Department of Health Service and Population Research (R.S.), King's College London (Institute of Psychiatry), London, United Kingdom; and the Department of Epidemiology and Public Health (V.H.), Royal Free and University College London Medical School, University College London, United Kingdom.
Objective: To investigate the association between vitamin D deficiency and depressive symptoms in a national community sample of older people. Vitamin D deficiency is common in older people with potential effects on mood.
Methods: Data were analyzed from 2070 participants aged >/=65 years who had participated in the 2005 Health Survey for England. Serum 25-hydroxy vitamin D (25(OH)D) levels and depressive symptoms (Geriatric Depression Scale) had been measured. Covariates included age, sex, social class, season of examination, and physical health status.
Results: Depressive symptoms were associated with clinical vitamin D deficiency (25(OH)D levels <10 ng/mL; present in 9.8%) independent of other covariates but not with broader deficiency states. This association was not modified by season of examination.
Conclusion: Vitamin D deficiency is associated with late-life depression in northern latitudes. PMID: 20595420