Photochem Photobiol Sci. 2012 Sep 18.
Departments of Medicine and Dermatology, San Francisco VA Medical Center and University of California, San Francisco, CA, USA. daniel.bikle at ucsf.edu.
Non-melanoma skin cancers (NMSC) are the most common type of cancer, occurring at a rate of over 1 million per year in the United States. Although their metastatic potential is generally low, they can and do metastasize, especially in the immune compromised host, and their surgical treatment is often quite disfiguring.
Ultraviolet radiation (UVR) as occurs with sunlight exposure is generally regarded as causal for these malignancies, but UVR is also required for vitamin D synthesis in the skin.
Based on our own data and that reported in the literature, we hypothesize that the vitamin D produced in the skin serves to suppress UVR epidermal tumor formation.
In this review we will first discuss the evidence supporting the conclusion that the vitamin D receptor (VDR), with or without its ligand 1,25-dihydroxyvitamin D, limits the propensity for cancer formation following UVR.
We will then explore three potential mechanisms for this protection:
- inhibition of proliferation and stimulation of differentiation,
- immune regulation, and
- stimulation of DNA damage repair (DDR).
– – – – – – – – – –
- Search Bikle in VitaminDWiki 165 items as of Sept 2012
- Vitamin D protects DNA against UV skin damage – 5 studies 2012-2013 Bikle is 1 of the 5
- Overview Suntans melanoma and vitamin D
- All items in Melanoma and Vitamin D
- More sun skin damage if vitamin D less than 20 ng – Sept 2012
- Native American Indians mostly died of skin cancer
- What? You never heard that? Right. Because it didn't happen.
- Hypothesis – worldwide increase in Melanoma due to UVA – Oct 2011
- Overview Skin and vitamin D
- Hypothesis – Increasing Folate or vitamin D decreases probability of skin cancer – July 2012
- Overview UV and Vitamin D
Hypothesis: vitamin D suppresses skin cancer – Sept 2012
- Red-haired mice can get melanoma without UV - Oct 2012 confirmed with mice
5632 visitors, last modified 01 Jun, 2013,This page is in the following categories (# of items in each category)