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Diabetes in Saudi women improved with just 2,000 IU of vitamin D – July 2012

Vitamin D supplementation as an adjuvant therapy for patients with T2DM: an 18-month prospective interventional study

Nasser M Al-Daghri, Khalid M Alkharfy, Abdulaziz Al-Othman, Emad El-Kholie, Osama Moharram, Majed S Alokail, Yousef Al-Saleh, Shaun Sabico, Sudhesh Kumar and George Chrousos
Cardiovascular Diabetology 2012, 11:85 doi:10.1186/1475-2840-11-85; Published: 18 July 2012

Background
Vitamin D deficiency has been associated with impaired human insulin action, suggesting a role in the pathogenesis of diabetes mellitus type 2 (T2DM). In this prospective interventional study we investigated the effects of vitamin D3 supplementation on the metabolic profiles of Saudi T2DM subjects pre- and post-vitamin D supplementation over an 18-month period.

Methods
T2DM Saudi subjects (men, N=34: Age: 56.6 +/- 8.7 yr, BMI, 29.1 +/- 3.3kg/m2; women, N=58: Age: 51.2 +/- 10.6 yr, BMI 34.3 +/- 4.9 kg/m2;) were recruited and given 2000 IU vitamin D3 daily for 18 months. Anthropometrics and fasting blood were collected (0, 6, 12, 18 months) to monitor serum 25-hydroxyvitamin D using specific ELISA, and to determine metabolic profiles by standard methods.

Results
In all subjects there was a significant increase in mean 25-hydroxyvitamin D levels from baseline (32.2+/-1.5nmol/L) to 18 months (54.7+/-1.5nmol/L; p<0.001), as well as serum calcium (baseline=2.3+/-0.23mmol/L vs. 18 months=2.6+/-0.1mmol/L; p=0.003).

A significant decrease in

  • LDL- (baseline=4.4+/-0.8mmol/L vs. 18 months=3.6+/-0.8mmol/L, p<0.001] and
  • total cholesterol (baseline=5.4+/-0.2mmol/L vs. 18 months=4.9+/-0.3mmol/L, p<0.001)

were noted, as well as a significant improvement in HOMA-beta function (p=0.002).
Majority of the improvements elicited were more prominent in women than men.

Conclusion
In the Saudi T2DM population receiving oral Vitamin D3 supplementation (2000 IU/day), circulating 25-hydroxyvitamin D levels remained below normal 18 months after the onset of treatment.

Yet, this "suboptimal" supplementation significantly improved lipid profile with a favorable change in HDL/LDL ratio, and HOMA-beta function, which were more pronounced in T2DM females.
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PDF is attached at the bottom of this page

Notes

  1. Women in the Middle East have extremely low levels of vitamin D (clothing)
    so it is understandable that women would get the benefit of vitamin D before then men
  2. PDF shows good improvements in insulin levels, which are not mentioned in the abstract

See also VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
1463 Diabetes and 2000 IU of vitamin D - July 2012.pdf PDF admin 19 Jul, 2012 12:44 370.33 Kb 880
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