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Hip fractures reduced 30 percent with 800 IU of vitamin D – meta-analysis July 2012

A pooled analysis of vitamin D dose requirements for fracture prevention.

N Engl J Med. 2012 Jul 5;367(1):40-9.
Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, Flicker L, Wark J, Jackson RD, Cauley JA, Meyer HE, Pfeifer M, Sanders KM, Stähelin HB, Theiler R, Dawson-Hughes B.
Center on Aging and Mobility, University of Zurich and Waid City Hospital, Zurich, Switzerland.

BACKGROUND: The results of meta-analyses examining the relationship between vitamin D supplementation and fracture reduction have been inconsistent.

METHODS: We pooled participant-level data from 11 double-blind, randomized, controlled trials of oral vitamin D supplementation (daily, weekly, or every 4 months), with or without calcium, as compared with placebo or calcium alone in persons 65 years of age or older. Primary end points were the incidence of hip and any nonvertebral fractures according to Cox regression analyses, with adjustment for age group, sex, type of dwelling, and study. Our primary aim was to compare data from quartiles of actual intake of vitamin D (including each individual participant's adherence to the treatment and supplement use outside the study protocol) in the treatment groups of all trials with data from the control groups.

RESULTS: We included 31,022 persons (mean age, 76 years; 91% women) with 1111 incident hip fractures and 3770 nonvertebral fractures. Participants who were randomly assigned to receive vitamin D, as compared with those assigned to control groups, had a nonsignificant 10% reduction in the risk of hip fracture (hazard ratio, 0.90; 95% confidence interval [CI], 0.80 to 1.01) and a 7% reduction in the risk of nonvertebral fracture (hazard ratio, 0.93; 95% CI, 0.87 to 0.99). By quartiles of actual intake, reduction in the risk of fracture was shown only at the
highest intake level (median, 800 IU daily; range, 792 to 2000), with a 30% reduction in the risk of hip fracture (hazard ratio, 0.70; 95% CI, 0.58 to 0.86) and a 14% reduction in the risk of any nonvertebral fracture (hazard ratio, 0.86; 95% CI, 0.76 to 0.96). Benefits at the highest level of vitamin D intake were fairly consistent across subgroups defined by age group, type of dwelling, baseline 25-hydroxyvitamin D level, and additional calcium intake.

CONCLUSIONS:
High-dose vitamin D supplementation (?800 IU daily) was somewhat favorable in the prevention of hip fracture and any nonvertebral fracture in persons 65 years of age or older. (Funded by the Swiss National Foundations and others.).

Comment in: Vitamin D- -baseline status and effective dose. [N Engl J Med. 2012]
PMID: 22762317


A few Charts in the PDF

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PDF is attached at the bottom of this page

Cofactors of Calcium, Magnesium, and Vitamin K are also VERY IMPORTANT for strong bones

See also VitaminDWiki

FACT: Bones need Calcium (this has been known for a very long time)
FACT: Vitamin D improves Calcium bioavailability (3X ?)
FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Caclium becomes too bio-available)
FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
FACT: Vitamin D supplements are very low cost
FACT: Many trials, studies. reviews, and meta-analysis have found that adding vitamin D reduces osteoporosis
FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
FACT: Cofactors help build bones.
It appears that to TREAT Osteoporosis:

  • Calcium OR vitamin D is OK,
  • Calcium + vitamin D is GOOD,
  • Calcium + vitamin D + other cofactors is GREAT

CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
Take about 750 mg of Calcium and 2000+ IU of vitamin D and Co-factors daily

Attached files

ID Name Comment Uploaded Size Downloads
1994 Pooled Hip2.jpg admin 22 Jan, 2013 12:39 50.01 Kb 1315
1993 Pooled1.jpg admin 22 Jan, 2013 12:39 23.03 Kb 1065
1992 Pooled.pdf PDF admin 22 Jan, 2013 12:39 515.91 Kb 622
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