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40 ng response plateau to 2000 to 4,000 IU of vitamin D – June 2012

Vitamin D status of female healthcare employees of childbearing age

G Plotnikoff 1*, K Mullin 2, L Mahlke 2, S Calvin 3, M Finch 4 and J Dusek 1
* Corresponding author
1 Allina Center for Healthcare Innovation, Minneapolis, USA
2 Allina Healthcare Employee Benefits , Minneapolis, USA
3 Minnesota Perinatal Physicians, Minneapolis, USA
4 University of Minnesota Carlson School of Business, Minneapolis, USA
BMC Complementary and Alternative Medicine 2012, 12(Suppl 1):P157 doi:10.1186/1472-6882-12-S1-P157; Published: 12 June 2012

© 2012 Plotnikoff et al; licensee BioMed Central Ltd.


Summary by VitaminDWiki

5600 Mid-West women

Vitamin D levels <20 ng<30ng<40 ng
Average32% 65% 87%
If take 200-400 IU18%60%85%

If take 1000 – 2000 IU 34 ng average
If take 2000-3000 IU40 ng average
If take 3000-4000 IU 39 ng average
If take > 4,000 IU38 ng average

Strange: plateau response

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Purpose: To examine the relationship between vitamin D status, reported vitamin D intake and body mass index in female health care employees.

Methods: Prospective observation study of 10,646 employees of a Midwestern integrated health care system who were measured for 25-OH-vitamin D by CLIA technology.

Results
A total of 5,628 women (aged 15-49) met eligibility criteria. Of these, 1,710 (32.4%) did not meet 2010 ACOG or IOM vitamin D guidelines for vitamin D sufficiency (? 20 ng/ml); 3,684 (65.5%) did not meet 2010 international guidelines (? 30 ng/ml); and 4,874 (86.6%) did not meet 2011 Endocrine Society guidelines (40-60 ng/ml). Only 2,644 (46.97%) reported taking any vitamin D. For those participants who reported vitamin D3 intake equal to that found in prenatal and multivitamins (200-400 IUs) (n = 430), 17.7% had 25-OH-vitamin D levels <20 ng/ml, 59.5% had levels <30 ng/ml, and 85.3% had levels <40 ng/ml. Mean 25-OH-vitamin D serum levels and standard deviations for higher reported vitamin D3 daily intakes of 1,001-2,000 IUs, 2001-3,000 IUs and 3,001-4,000 IUs and >4,000 IUs were 34.09 ng/ml (12.79), 39.52 ng/ml (16.16), 38.57 ng/ml (17.06) and 37.98 ng/ml (16.40), respectively. For all of these reported intakes, women with a BMI ? 30 exhibited significantly lower 25-OH-vitamin D status compared to those women with BMI < 30 (p <.0001).

Conclusion
Female healthcare workers of child bearing age demonstrate a high incidence of vitamin D deficiency. Daily prenatal or multivitamin supplementation does not ensure adequate 25-OH-vitamin D levels. A BMI ?30 represents a substantially increased risk of suboptimal 25-OH-vitamin D status. Reported daily intake of >4,000 IUs did not result in elevated serum levels of vitamin D. These findings have substantial public health implications as vitamin D deficiency has been associated with increased obstetrical and perinatal risks including gestational diabetes mellitus, premature delivery and emergent c-section.
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