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If vitamin D levels were not changed, toxicity to chemotherapy did not vary with levels – May 2012

The relationship between vitamin D and chemotherapy-induced toxicity - a pilot study.

Br J Cancer. 2012 May 15. doi: 10.1038/bjc.2012.194.
Kitchen D, Hughes B, Gill I, O'Brien M, Rumbles S, Ellis P, Harper P, Stebbing J, Rohatgi N.
1] Leaders in Oncology Care (LOC), 95 Harley Street, London W1G 6AF, UK [2] Barts and The London School of Medicine and Dentistry, Garrod Building, Turner Street, London E1 2AD, UK.

Background:There are anecdotal data that lower levels of vitamin D may be associated with increased levels of toxicity in individuals receiving chemotherapy; we therefore wished to investigate this further.Methods:From a cohort of over 11?000 individuals, we included those who had vitamin D levels (serum 1,25(OH)(2)D3) measured before and during chemotherapy. They were analysed for side effects correlating Chemotherapy Toxicity Criteria with vitamin D levels, normalising data for general markers of patient health including C-reactive protein and albumin.Results:A total of 241 (2% of the total cohort) individuals entered the toxicity analysis. We found no overall difference in toxicity effects experienced by patients depending on whether they were vitamin D depleted or had sufficient levels (P=0.78).

Conclusion:This pilot study suggests routine vitamin D measurement during treatment does not appear to be necessary in the management of chemotherapy-induced toxicity.British Journal of Cancer advance online publication, 15 May 2012; doi:10.1038/bjc.2012.194 www.bjcancer.com.

PMID: 22588559
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Note: this study DOES NOT conclude that vitamin D levels can be increased during chemotherapy without toxicity problems

See also VitaminDWiki

see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=396

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