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Cystic fibrosis associated with low vitamin D – May 2012

Vitamin D bioavailability in cystic fibrosis: a cause for concern?

Nutr Rev. 2012 May;70(5):280-93. doi: 10.1111/j.1753-4887.2012.00471.x. Epub 2012 Mar 30.
Mailhot G. genevieve.mailhot at umontreal.ca
Research Centre, CHU Sainte-Justine, Department of Nutrition, Université de Montréal, Montréal, Canada.

Despite the inclusion of extra vitamin D in their regimen of fat-soluble vitamin supplementation, cystic fibrosis patients remain chronically depleted of vitamin D. The persistence of suboptimal vitamin D status is often blamed on the maldigestion and malabsorption of fat.

However, the mitigated success of recent clinical trials with high-dose vitamin D supplementation suggests that vitamin D bioavailability might be impaired in these patients. Given the growing understanding of the importance of this vitamin in the regulation of multiple biological functions beyond skeletal health, the present review analyzes the current literature by addressing each step of vitamin D metabolism and action in the context of this life-limiting pathology. In addition, it highlights the importance of vitamin D in relation to organs and or conditions affected by cystic fibrosis.

© 2012 International Life Sciences Institute.

PMID: 22537214
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