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Sickle Cell Anemia: 64 percent had less than 10ng of vitamin D – April 2012

Vitamin D Deficiency and Comorbidities in Children with Sickle Cell Anemia

Pediatr Hematol Oncol. 2012 Apr;29(3):261-6. (doi:10.3109/08880018.2012.661034)
Tara Christine Jackson,1 Melissa Jo Krauss, MPH,2 Michael Rutledge DeBaun, MD, MPH,3 Robert Charles Strunk, MD,4 and Ana Maria Arbeláez, MD, MSCI4
1 Department of Pediatrics, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri, USA
2 Division of Biostatistics, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri, USA
3 Department of Pediatrics, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri, USA; and Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA
4 Department of Pediatrics, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri, USA
Address correspondence to Ana Maria Arbeláez, MD, MSCI, Division of Pediatric Endocrinology, Washington University in St. Louis,
School of Medicine, 660 South Euclid, Campus Box 8116-NWT, St. Louis, MO 63110–1077, USA. E-mail: arbelaez_a at kids.wustl.edu

Vitamin D deficiency is known to be common among patients with sickle cell anemia (SCA).
Vitamin D levels were measured in 139 children (aged 7.9 to 15.1 years) to study its association with SCA morbidities;
severe deficiency <10 ng/mL was present in 64.0% and only 2.2% were sufficient (>30 ng/mL).

Vitamin D levels

  • were associated with pulmonary function (forced expiratory volume in 1 second [FEV1]), but
  • not associated with either rates of acute pain or acute chest syndrome episodes.

Further studies are needed to be able to compare outcomes in those with deficiency to those with sufficiency, as well as to treating patients with SCA with vitamin D to better establish a possible link, if any, between vitamin D and SCA morbidity.
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See also VitaminDWiki

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