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Medical Causes of Vitamin D Deficiency

Table 2 from Vitamin D: An Evidence-Based Review – 2009

Causes Example
Reduced skin synthesis Sunscreen, skin pigment, season/latitude/time of day, aging, skin grafts
Decreaseed absorption Cystic fibrosis, celiac disease, whipple disease, Crohn disease, gastric bypass, medications that reduce cholesterol absorption
Increased sesquestration Obesity
Increased catabolism Anticonvulsant, glucocorticoid, highly active antiretroviral treatment, and some immunosuppressants
Decreased synthesis of
25-hydroxyvitamin D
Hepatic failure
Increased urinary loss of
25-hydroxyvitamin D
Nephrotic proteinuria
Decreased synthesis of 1,25-dihydroxyvitamin D Chronic renal failure
Heritable disorders Genetic mutations causing rickets, or vitamin D resistance
Acquired disorders Tumor-induced osteomalacia, primary hyperparathyroidism, hyperthyroidism, granulomatous disorders such as sarcoidosis, tuburculosis, and some lymphomas

See also VitaminDWiki