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Statin use increased probability of diabetes in women by 48 percent – perhaps via vitamin D Jan 2012

- Fact: Many statins reduce vitamin D
- Fact: Low levels of vitamin D increase probability of diabetes and Overview

Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative

Annie L. Culver, BPharm; Ira S. Ockene, MD; Raji Balasubramanian, ScD; Barbara C. Olendzki, RD, MPH; Deidre M. Sepavich, MBA; Jean Wactawski-Wende, PhD; JoAnn E. Manson, MD, DrPH; Yongxia Qiao, MD; Simin Liu, MD, ScD; Philip A. Merriam, MSPH; Catherine Rahilly-Tierny, MD, MPH; Fridtjof Thomas, PhD; Jeffrey S. Berger, MD, MS; Judith K. Ockene, PhD, MEd, MA; J. David Curb, MD; Yunsheng Ma, MD, PhD
Arch Intern Med. Published online January 9, 2012. doi:10.1001/archinternmed.2011.625

Background This study investigates whether the incidence of new-onset diabetes mellitus (DM) is associated with statin use among postmenopausal women participating in the Women's Health Initiative (WHI).

Methods The WHI recruited 161 808 postmenopausal women aged 50 to 79 years at 40 clinical centers across the United States from 1993 to 1998 with ongoing follow-up. The current analysis includes data through 2005. Statin use was captured at enrollment and year 3. Incident DM status was determined annually from enrollment. Cox proportional hazards models were used to estimate the risk of DM by statin use, with adjustments for propensity score and other potential confounding factors. Subgroup analyses by race/ethnicity, obesity status, and age group were conducted to uncover effect modification.

Results This investigation included 153 840 women without DM and no missing data at baseline. At baseline, 7.04% reported taking statin medication. There were 10 242 incident cases of self-reported DM over 1 004 466 person-years of follow-up. Statin use at baseline was associated with an increased risk of DM (hazard ratio HR, 1.71; 95% CI, 1.61-1.83). This association remained after adjusting for other potential confounders (multivariate-adjusted HR, 1.48; 95% CI, 1.38-1.59) and was observed for all types of statin medications. Subset analyses evaluating the association of self-reported DM with longitudinal measures of statin use in 125 575 women confirmed these findings.

Conclusions Statin medication use in postmenopausal women is associated with an increased risk for DM.
This may be a medication class effect. Further study by statin type and dose may reveal varying risk levels for new-onset DM in this population.
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See also VitaminDWiki

Diseases that may be related via low vitamin D - Diabetes relationship as of March 2017

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VitaminDWiki pages with STATIN in title (25 as of June 2022)

This list is automatically updated

Items found: 25
Title Modified
Statins and Vitamin D - many studies 15 Jul, 2023
Statin muscle problems decreased in 4 out of 5 patients when vitamin D was added – June 2022 30 Jun, 2022
Statin pain reduces Vitamin D levels by 4 ng ( 9 studies) - Meta-analysis July 2021 23 Jul, 2021
Statin side-effects are reduced by Vitamin D – US patent Application – April 2019 14 Nov, 2019
Statin pain eliminated by 7100 IU vitamin D (50000 IU weekly) – July 2011 21 Jul, 2019
Most Profitable Pill in Medical History Is Based on Flawed Science (Statins) May 2019 02 Jun, 2019
Low-dose statin plaque formation stopped by Omega-3 – RCT Dec 2017 24 Jan, 2018
Statin-induced Myalgias corrected with 100000 weekly Vitamin D2 20 Jul, 2017
Statin use increased probability of diabetes in women by 48 percent – perhaps via vitamin D Jan 2012 19 Mar, 2017
Statin use increased probability of diabetes by 48 percent – perhaps via vitamin D Jan 2012 19 Mar, 2017
The statin Crestor dramatically increases levels of vitamin D in the blood – Jan 2012 17 May, 2016
Some statins increase skin cancer risk by 40 percent (reducing vitamin D levels) – Jan 2016 10 Jan, 2016
Theories on the interaction between statins and vitamin D – 2012 10 Jan, 2016
If you must take statins and want to avoid hardening of arteries, take vitamin K2 – RCT May 2015 22 May, 2015
One statin decreased vitamin D levels but the other did not – March 2010 14 Apr, 2015
Not all statins increase vitamin D levels – Dec 2010 14 Apr, 2015
Off topic – Hypertension and statin pain reduced by Coenzyme Q10 – 2010 26 Jan, 2015
Statins with low vitamin D increased chance of musculoskeletal pain by 2X – Jan 2015 29 Nov, 2014
Statin pain associated with 10 ng less vitamin D – meta-analysis Oct 2014 24 Oct, 2014
Diabetics have problems with low Magnesium , especially if taking statins – Aug 2013 08 May, 2014
Statin-induced Myalgias corrected with 100000 weekly Vitamin D 04 May, 2014
Off topic: Statins associated with increased cataracts (wonder about low vitamin D) - Sept 2013 29 Sep, 2013
Diabetics have problems with low Magnesium, especially if taking statins – Aug 2013 28 Aug, 2013
Breast cancer 2X more likely if have taken statins for 10 years – July 2013 11 Jul, 2013
Statins associated with 14X increase in Polymyalgia Rheumatica (a new disease) – Aug 2012 09 Nov, 2012

Attached files

ID Name Comment Uploaded Size Downloads
1008 Statin-associated diseases.jpg admin 12 Jan, 2012 24.79 Kb 3361