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Vitamin D helped cardiovascular patients in many ways– Nov 2011

Vitamin D Deficiency and Supplementation and Relation to Cardiovascular Health

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Summary by VitaminDWiki:

11,000 cardiology patients in Kansas (2004-2009) were allowed to take any amount of vitamin D they wanted
They were analyzed as being in one of two groups: sufficient and deficient
Those with an average of 40 ng/ml of vitamin D did MUCH better than those with an average of only 17 ng/ml
2X fewer deaths after 5 years, lower blood pressure, less atrial fibrillation, less diabetes, lower weight, etc.
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James L. Vacek, MD, Msc jlvacek at mac.md; Subba Reddy Vanga, MBBS; Mathew Good, DO; Sue Min Lai, PhD; Dhanunjaya Lakkireddy, MD; Patricia A. Howard, PharmD
Received 18 July 2011; received in revised form 13 September 2011; accepted 13 September 2011. published online 10 November 2011. Americal Journal of Cardiology

Recent evidence supports an association between vitamin D deficiency and hypertension, peripheral vascular disease, diabetes mellitus, metabolic syndrome, coronary artery disease, and heart failure. The effect of vitamin D supplementation, however, has not been well studied. We examined the associations between vitamin D deficiency, vitamin D supplementation, and patient outcomes in a large cohort. Serum vitamin D measurements for 5 years and 8 months from a large academic institution were matched to patient demographic, physiologic, and disease variables.

The vitamin D levels were analyzed as a continuous variable and as normal (?30 ng/ml) or deficient (<30 ng/ml). Descriptive statistics, univariate analysis, multivariate analysis, survival analysis, and Cox proportional hazard modeling were performed.

Of 10,899 patients, the mean age was 58 ± 15 years, 71% were women (n = 7,758), and the average body mass index was 30 ± 8 kg/m2. The mean serum vitamin D level was 24.1 ± 13.6 ng/ml. Of the 10,899 patients, 3,294 (29.7%) were in the normal vitamin D range and 7,665 (70.3%) were deficient.

Vitamin D deficiency was associated with several cardiovascular-related diseases, including

  • hypertension,
  • coronary artery disease,
  • cardiomyopathy, and
  • diabetes (all p <0.05).


Vitamin D deficiency was a strong independent predictor of all-cause death
(odds ratios 2.64, 95% confidence interval 1.901 to 3.662, p <0.0001) after adjusting for multiple clinical variables.

Vitamin D supplementation conferred substantial survival benefit (odds ratio for death 0.39, 95% confidence interval 0.277 to 0.534, p <0.0001).

In conclusion, vitamin D deficiency was associated with a significant risk of cardiovascular disease and reduced survival.
Vitamin D supplementation was significantly associated with better survival, specifically in patients with documented deficiency.
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Cardiology patients who were vitamin D sufficient

- 23% took vitamin D: between 1,000 IU daily to 50,000 IU every two weeks:
- had average 40 ng/ml of vitamin D

The cardiology patients who were deficient had only 17 ng/ml

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The cardiology patients after 5 years:

  • 4 % died who had average of 40 ng of vitamin D
  • 8 % died who had average of 17 ng of vitamin D

There were many measurable benefits of extra vitamin D

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If registered (free) CLICK HERE for PDF

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See also VitaminDWiki

See also in VitaminDWiki Cardiovascular and MORTALITY

see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=1784

See also in VitaminDWiki HYPERTENSION and BLOOD PRESSURE

Attached files

ID Name Comment Uploaded Size Downloads
966 cardiovascular T2B.jpg admin 25 Dec, 2011 12:35 32.98 Kb 843
965 cardiovascular T2A.jpg admin 25 Dec, 2011 12:35 25.96 Kb 889
964 Cardiovascular chart.jpg Chart admin 25 Dec, 2011 12:34 33.11 Kb 1299
906 cardiologyt1b.jpg admin 29 Nov, 2011 13:58 48.50 Kb 772
905 cardiologyt1a.jpg admin 29 Nov, 2011 13:58 62.83 Kb 891
904 death vs deficiency.jpg admin 29 Nov, 2011 13:57 56.41 Kb 828
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