Cancer Epidemiol Biomarkers Prev. 2011 Nov 15.
Wolpin BM, Ng K, Bao Y, Kraft P, Stampfer MJ, Michaud DS, Ma J, Buring JE, Sesso H, Lee IM, Rifai N, Cochrane BB, Wactawaski-Wende J, Chlebowski RT, Willett WC, Manson JE, Giovannucci EL, Fuchs CS.
1 Dept of Medical Oncology, Dana-Farber Cancer Institute.
Laboratory studies suggest vitamin D may inhibit pancreatic cancer cell growth.
However, epidemiologic studies of vitamin D and pancreatic cancer risk have been conflicting.
To determine whether prediagnostic levels of plasma 25-hydroxyvitamin D (25[OH]D) were associated with risk of pancreatic cancer, we performed a nested case-control study of 451 cases and 1167 controls from five cohorts through 2008.
Logistic regression was used to compare the odds of pancreatic cancer by plasma level of 25(OH)D.
Mean plasma 25(OH)D was lower in cases versus controls (61.3 vs. 64.5 nmol/L, P=0.005).
In logistic regression models, plasma 25(OH)D was inversely associated with odds of pancreatic cancer.
Participants in quintiles two through five had multivariable-adjusted odds ratios (OR [95% confidence intervals]) of
- 0.79 (0.56-1.10),
- 0.75 (0.53-1.06),
- 0.68 (0.48-0.97), and
- 0.67 (0.46-0.97); P-trend=0.03), respectively, compared to the bottom quintile.
Compared to those with insufficient levels (25[OH]D<50 nmol/L), ORs were
- 0.75 (0.58-0.98) for subjects with relative insufficiency (25[OH]D 50-<75 nmol/L) and
- 0.71 (0.52-0.97) for those with sufficient levels (25[OH]D?75 nmol/L).
No increased risk was noted in subjects with 25(OH)D ?100 nmol/L, as suggested in a prior study.
In subgroup analyses, ORs for the top versus bottom quartile of 25(OH)D were
- 0.72 (0.48-1.08) for women,
- 0.73 (0.40-1.31) for men, and
- 0.73 (0.51-1.03) for Whites.
Among participants in five large prospective cohorts, higher plasma levels of 25(OH)D were associated with a lower risk for pancreatic cancer.
Impact: Low circulating 25(OH)D may predispose individuals to the development of pancreatic cancer.
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