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Hypothesis – worldwide increase in Melanoma due to UVA – Oct 2011

Worldwide Increasing Incidences of Cutaneous Malignant Melanoma

J Skin Cancer. 2011; 2011: 858425.
Published online 2011 October 10. doi: 10.1155/2011/858425
PMCID: PMC3191827
Dianne E. Godar dianne.godar at fda.hhs.gov
Center for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Avenue, WO64-4024, Silver Spring, MD 20993, USA
Received November 20, 2010; Revised April 6, 2011; Accepted August 11, 2011.

The incidence of cutaneous malignant melanoma (CMM) has been increasing at a steady rate in fair-skinned populations around the world for decades.
Scientists are not certain why CMM has been steadily increasing, but strong, intermittent UVB (290–320 nm) exposures, especially sunburn episodes, probably initiate, CMM, while UVA (321–400 nm) passing through glass windows in offices and cars probably promotes it.
The CMM incidence may be increasing at an exponential rate around the world, but it definitely decreases with increasing latitude up to ~50°N where it reverses and increases with the increasing latitude.

The inversion in the incidence of CMM may occur because there is more UVA relative to UVB for most of the year at higher latitudes.

If windows, allowing UVA to enter our indoor-working environment and cars, are at least partly responsible for the increasing incidence of CMM, then UV filters can be applied to reduce the rate of increase worldwide.

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