Virtually the entire world recognizes that sunblock greatly reduces the amount of vitamin D you can get from the sun.
AVIDAS PHARMACEUTICALS has been granted an international patent to add vitamin D to sunscreen lotions and skin lotions.
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0.1 International Units per square centimeter (IU/cm2) to about 1000 IU/cm2
disorders and diseases associated with low calcium uptake; bone-related disorders and diseases including osteopenia, osteomalacia, osteoporosis, and rickets; vascular disorders and diseases including coronary artery disease, high blood pressure, and peripheral artery disease; autoimmune disorders and diseases including multiple sclerosis, fibromyalgia, rheumatoid arthritis, Grave's disease, and lupus; tuberculosis; periodontal disorders and diseases; chronic pain; seasonal affective disorder; cognitive impairment; depression; type I diabetes; chronic renal disease; hypoparathyroid; Parkinson's disease, and certain types of cancers, including breast cancer, prostate cancer, colon cancer, and skin cancer.
 The instant invention also includes therapeutic vitamin D formulations generally as taught above, but that do not include a sun-protecting agent. Formulations according to this Example include a vitamin D compound present in an amount that, when administered to an individual (preferably, transdermally in one or more applications), is therapeutically effective to increase the individual's serum vitamin D levels.
 The inventive formulations may, in various exemplary, non-limiting embodiments, be provided in forms suitable for topical administration and that result in the transdermal delivery of a therapeutically effective amount of vitamin D, for example and without limitation the inventive formulations may be provided as creams, gels, liquids, lotions, solutions, sprays, emulsions, aerosols, and combinations thereof, and may provide multilamellar vesicles, liposomes, nanospheres, microsponges, or combinations thereof. In certain exemplary, non-limiting embodiments, the active agents, including vitamin D, may be encapsulated (including microencapsulated) in the inventive formulations, for example, to be released when the encapsulation is ruptured under pressure, for time-release of the agent, and so forth. Suitable encapsulating materials and techniques, including those which release the encapsulated agent over time, are known in the art.
- Pharmaceutical dosage form for transdermal administration US Patent 6,538,039 March 2003
- A froum discussion of transdermal vitamin D Sept 2010
- MATRIX TYPE PATCH FOR TRANSDERMAL ADMINISTRATION OF VITAMIN D ANALOG AND THE USE THEREOF (WO/2004/028515) 2004
Patent application for Vitamin D added to sunscreen (already patented)
THERAPEUTIC VITAMIN D SUN-PROTECTING FORMULATIONS AND METHODS FOR THEIR USE
United States Patent Application 20150050226 Kind Code: A1
The present invention concerns topical sun-protecting formulations including therapeutically effective amounts of Vitamin D, including formulations that provide Vitamin D in bioavailable amounts that correspond to decreased natural Vitamin D production resulting from the sun-blocking effects of the formulations and formulations for the prevention and treatment of disorders and disease states associated with vitamin D deficiency and vitamin D insufficiency.
Gardner, Margaret M. (Gladwyne, PA, US)
Pamplin III, Charles L. (Chapel Hill, NC, US)
Application Number: 14/222222
Publication Date: 02/19/2015 Filing Date: 03/21/2014