Chances of live birth after exposure to vitamin D–fortified margarine in women with fertility problems: results from a Danish population-based cohort study
Fertility and Sterility - February 2020 Vol113, Issue 2, Pages 383–391
Allan Jensen, M.Sc., Ph.D.a, M.Sc., Ph.D. Allan Jensen M.Sc., Ph.D. Allan Jensen, Michella L. Nielsen, M.D.b, Sonia Guleria, M.D.a, Susanne K. Kjaer, M.D., D.M.Sc.a,c, Berit L. Heitmann, Ph.D., D.M.Sc.d,e,f, Ulrik S. Kesmodel, M.D., Ph.D.b,g,h,i
Fertility and Sperm category contains the following summary
Overview Women and Vitamin D
Overview Pregnancy and vitamin D Fertility and Vitamin D – several articles
Ensure a healthy pregnancy and baby - take Vitamin D before conception
Search VitaminDWiki for IVF OR "IN VITRO FERTILIZATION" 345 items as of Sept 2019
Search VitaminDWiki for "Assisted reproduction" 177 items as of Sept 2019
Search VitaminDWiki for "polycystic ovary syndrome" OR PCOS" Sept 2019
Search VitaminDWiki fore Testosterone 472 items as of Oct 2017
Search VitaminDWiki for "erectile dysfunction" 120 items as of July 2018
Conception and vitamin D snapshot as of 2012
- Birth rates doubled with Vitamin D- 300,000 loading dose for men – RCT Nov 2017
- Assisted Reproduction – 5 studies concluded vitamin D repletion helps – Review March 2015
- IVF 4X more successful for white women with lots of vitamin D – Oct 2012
- Assisted Reproduction might be aided by Vitamin D – review Dec 2014
- In-vitro Fertilization costs at least 10,000 dollars, Vitamin D costs 5 dollars
- Conception within 6 months 3X more likely if high vitamin D – Oct 2019
- Pregnancy success increased 30 percent if sunny (or vitamin D) one month earlier – June 2015
- Preconception vitamin D is great - every extra 10 ng associated with 10 percent more likely to have live birth – Aug 2018
- Women with more than minimum vitamin D were 3.4 X more likely to achieve pregnancy and 1.6 X more likely to have live births – June 2017
- Vitamin D is needed for human fertility – goal is 50 ng – Sept 2018
Increased male Vitamin D also increases fertility
- Vitamin D somewhat assists reproduction – both the mother and the father – May 2014
- Male fertility 4 X higher if high Vitamin D – Nov 2015
Fortification works, even if food is cooked, but govts rarely fortifiy with enough
Govts, food producers, and families can fortify:
milk, yogurt, beer, bread, cerals, cooking oil, soups, jams, jellys, snack bars, etc.
Some interesting fortification articles
- Vitamin D fortification of edible oils in India starting in 2017
- Vitamin D food fortification – many trials listed – Aug 2018
- International Conference of Vitamin D Fortification of Food (India) – Sept 2018
- Vitamin D fortification of milk helps (proven in Gemany this time) – RCT Dec 2013
- Improved health due to vitamin D fortification in Finland
- Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018
- Vitamin D added to margarine reduced inflammatory bowel disease by 13 percent 30 years later – Nov 2019
- Preeclampsia of offspring cut in half if mother who smoked had vitamin D fortified margarine – Dec 2017
- Danish study of childhood diseases vs vitamin D fortification – May 2013
- 9 studies by Denmak D-Tech group (fortifiy Margarine with Vitamin D) online as of Nov 2019
To study the association between extra vitamin D from a mandatory margarine fortification program and chance of live birth among infertile women.
Design: Nationwide cohort study.
Setting: Not applicable.
Patient(s): The study population consisted of 16,212 women diagnosed with infertility from June 1, 1980, to August 31, 1991.
We took advantage of the mandatory vitamin D fortification program of margarine in Denmark that was abruptly stopped on May 31, 1985. The termination of the vitamin D fortification served as a cutoff point to separate the study population into various exposure groups.
Main Outcome Measure(s)
Odds ratios and 95% confidence intervals for the association between vitamin D exposure status and chance of a live birth within 12, 15, and 18 months after first infertility diagnosis.
Women who were diagnosed with infertility during the vitamin D–exposed period had an increased chance of a live birth compared with women diagnosed with infertility during the nonexposed period. For women diagnosed with infertility during the wash-out period, the chance of a live birth was also increased, but somewhat lower. Similar estimates were obtained with longer follow-up, in women with anovulatory infertility, and little seasonal variation was observed when calendar period of conception was applied.
Our findings suggest that infertile women exposed to extra vitamin D from a margarine fortification program had an increased chance of live birth compared with women not exposed to extra vitamin D from fortification.
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