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Vitamin D fights treatment-resistant cancers (petrie dish) – June 2019

VitaminDWiki Summary

Vitamin D may be able to treat many multidrug-resistant diseases
Cells which pump drugs out of them have the protein MRP1
Calcitriol kills cells with MRP1 (in Petrie dish)
This may be the reason that Vitamin D helps Chemo, etc.

How vitamin D helps fight treatment-resistant cancer Medical News Today

  • “The researchers showed that calcitriol and calcipotriol can selectively hone in on cancer cells that have too much MRP1 and destroy them”
  • “… multidrug resistance-associated protein 1 (MRP1). The protein sits in the cell wall and drives a pump that ejects cancer drugs out of the cell.”
  • “Cancer cells that develop resistance to chemotherapy drugs often overexpress, or overproduce, transporter proteins. This abundance is the primary cause of chemoresistance”
  • MRP1 doesn't just reduce the effectiveness of cancer drugs, it can also weaken the effect of antibiotics, antivirals, anti-inflammatories, antidepressants, and drugs that treat HIV.

Reference

Calcitriol and Calcipotriol Modulate Transport Activity of ABC Transporters and Exhibit Selective Cytotoxicity in MRP1-overexpressing Cells
Kee W. Tan, Angelina Sampson, Bremansu Osa-Andrews and Surtaj H. Iram
Drug Metabolism and Disposition December 2018, 46 (12) 1856-1866; DOI: https://doi.org/10.1124/dmd.118.081612
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Created by admin. Last Modification: Thursday June 20, 2019 12:37:37 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
12162 Calcitriol MRP1.pdf PDF 2018 admin 19 Jun, 2019 21:27 1.13 Mb 10
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