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Response to UV varies more with pigment genes and age than skin color – Jan 2019

Pigment genes not skin pigmentation affect UVB-induced vitamin D

Photochemical & Photobiological Sciences, DOI:10.1039/C8PP00320C
Pameli Datta, Peter Alshede Philipsen, Peter Olsen, Bibi Petersen, Jeppe Dyrberg Andersen, Niels Morling and Hans Christian Wulf

VitaminDWiki

Items in both categories Dark Skin and UV are listed here:

Items in both categories Seniors and UV are listed here:


UV weekly dose was not constant. increased during the winter trial – Clipped from PDF
“All participants received identical UVB doses gradually increasing over nine weeks from October to December. UVB treatments, each of 0.94 kJ m−2 (2 SEDs), were administered bi-weekly during the first two weeks. In the following five weeks, the frequency was increased to three sessions per week. During the last two weeks, 3 weekly sessions, each of 1.4 kJ m−2 (3 SEDs), were administered. The total UVB dose during the nine weeks was 26 kJ m−2 (56 SEDs)"
This small study of 40 people appears to ignore the differences due to things such sa
Weight,
Low Magnesium,
Low Omega-3
Vitamin D genes
Smoking
Low Cholesterol
Anemia
DDT
Poor Liver
Excessive Vitamin A

Overview Dark Skin and Vitamin D contains the following summary

FACT - - People with dark skins have more health problems and higher mortality rate than those with light skins
FACT - - People with dark skins have low levels of vitamin D
FACT - - People with light skins who have low vitamin D have health problems
OBSERVATION - - The health problems of whites with low level of vitamin D are similar to those with dark skins
CONCLUSION - - People with dark skins have more health problems due to low levels of vitamin D

Blacks die more often than whites of many diseases (they have less vitamin D) – 2012 contains the following summary

Cancer Facts & Figures for African Americans Cancer.org

  • “African Americans have the highest death rate and shortest survival of any racial and ethnic group in the US for most cancers”
  • Has a huge number of tables and charts, Note: Vitamin D is not mentioned

Leading Causes of Death as of March 2018

All Ages Death rateBlackWhiteRatio
Heart diseases 217 1711.27
Cancer 1991701.17
Cerebrovascular diseases51361.4
Diabetes 40 192.0

Rates per 100,000    Age adjusted   Non-Hispanic


see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=645
The more the African Ancestry, the lower the vitamin D level – July 2010

 Download the PDF from Sci-Hub via VitaminDWiki
Vitamin D levels increased during the trial
Image

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Skin pigmentation is believed to contribute to the generally low serum 25-hydroxyvitamin D (25(OH)D) concentrations observed in darker-skinned persons. The influence of measured skin pigmentation on UVB-induced 25(OH)D increase was investigated together with 9 demographic and 13 genetic parameters (pigment SNPs).

Forty participants representing a wide range in measured skin pigmentation were exposed to identical UVB doses on identical body areas over nine weeks with weekly measurements of serum 25(OH)D.

This study took place in Denmark during winter, a period with negligible ambient UVB, so variation in 25(OH)D synthesis was not influenced by latitude, season, sun and clothing habits.

The increase in 25(OH)D concentration displayed considerable variation (range: 2.9 to 139 nmol L-1).
Constitutive and facultative skin pigmentation exerted separate influence on the variation of the UVB-induced linear 25(OH)D increase. However, this influence was statistically non-significant in the presence of separate significant pigment SNPs.

The variation in the 25(OH)D increase in the combined linear model was not explained by measured skin pigmentation but by sex, height, age and seven SNPs located in the ASIP, MTAP, MIR196A29 and Solute Carrier Family genes.

This linear model including individual intercepts and the 10 parameters influencing the slope explained 77.4% of the variation.

This study confirmed the influence of sex, age and height on 25(OH)D increase and found that pigment genes provided a better relation to UVB-induced 25(OH)D increase compared to the actual measured skin pigmentation. Therefore, only investigating skin pigmentation obscure other causal parameters for low 25(OH)D.

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Created by admin. Last Modification: Sunday March 24, 2019 19:51:40 GMT-0000 by admin. (Version 12)

Attached files

ID Name Comment Uploaded Size Downloads
11661 Pigment genes.pdf PDF 2019 admin 24 Mar, 2019 16:50 881.87 Kb 7
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