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Vitamin D levels rise during pregnancy – Oct 2016

Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort

Nutrients 2016, 8(10), 655; doi:10.3390/nu8100655
Linnea Bärebring 1, Inez Schoenmakers 2,3, Anna Glantz 4, Lena Hulthén 1, Åse Jagner 4, Joy Ellis 5, Mattias Bärebring 6, Maria Bullarbo 7,8 and Hanna Augustin 1

See also VitaminDWiki
< 10 ngMother was born in
45 % South Asia
40 % Middle East
26 % Sub-Saharan Africa
3% East Asia
1 % Western Europe

Pregnancy category starts with

920 items in Pregnancy category

 - see also

Healthy pregnancies need lots of vitamin D has the following summary
Most were taking 2,000 to 7,000 IU daily for >50% of pregnancy
   Click on hyperlinks for details

Problem
Vit. D
Reduces
Evidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

 Download the PDF from VitaminDWiki

Graphs of vitamin D during 1st and 3rd trimesters

Upper pair = All women (not just light skinned)
Lower pair = Asian/African women
Image

If very low Vitamin D (< 12 ng) the woman is 22X more likely to be an Asian woman

Image
Specuation: Muslim women wearing concealing clothing, and Swedish women taking cod liver oil and/or fish diet
There is currently little information on changes in vitamin D status during pregnancy and its predictors. The aim was to study the determinants of change in vitamin D status during pregnancy and of vitamin D deficiency (<30 nmol/L) in early pregnancy. Blood was drawn in the first (T1) and third trimester (T3). Serum 25-hydroxyvitamin D (25(OH)D) (N = 1985) was analysed by liquid chromatography tandem-mass spectrometry. Season-corrected 25(OH)D was calculated by fitting cosine functions to the data. Mean (standard deviation) 25(OH)D was 64.5(24.5) nmol/L at T1 and 74.6(34.4) at T3. Mean age was 31.3(4.9) years, mean body mass index (BMI) was 24.5(4.2) kg/m2 and 74% of the women were born in Sweden. Vitamin D deficiency was common among women born in Africa (51%) and Asia (46%) and prevalent in 10% of the whole cohort. Determinants of vitamin D deficiency at T1 were of non-North European origin, and had less sun exposure, lower vitamin D intake and lower age. Season-corrected 25(OH)D increased by 11(23) nmol/L from T1 to T3. The determinants of season-corrected change in 25(OH)D were origin, sun-seeking behaviour, clothing style, dietary vitamin D intake, vitamin D supplementation and recent travel <35° N. In conclusion, season-corrected 25(OH)D concentration increased during pregnancy and depended partly on lifestyle factors. The overall prevalence of vitamin D deficiency was low but common among women born in Africa and Asia. Among them, the determinants of both vitamin D deficiency and change in season-corrected vitamin D status were fewer, indicating a smaller effect of sun exposure.

Attached files

ID Name Comment Uploaded Size Downloads
7219 OR of less than 12 ng in T1.jpg admin 22 Oct, 2016 10.91 Kb 531
7218 preg vs season.jpg admin 22 Oct, 2016 45.36 Kb 647
7217 Pregnancy and Vit D 1st and 3rd trimester.pdf admin 22 Oct, 2016 429.85 Kb 638