Translate Register Log In Login with facebookLogin and Register

Vitamin D generated by the sun is associated with pigmentation genes, not skin color – Jan 2019

Pigment genes not skin pigmentation affect UVB-induced vitamin D

Photochemical & Photobiological Sciences, DOI:10.1039/C8PP00320C
Pameli Datta, Peter Alshede Philipsen, Peter Olsen, Bibi Petersen, Jeppe Dyrberg Andersen, Niels Morling and Hans Christian Wulf


This study small study of 40 people appears to ignore the differences due to
Low Magnesium,
Low Omega-3
Vitamin D genes
Low Cholesterol
Poor Liver
Excessive Vitamin A

Overview Dark Skin and Vitamin D contains the following summary

FACT - - People with dark skins have more health problems and higher mortality rate than those with light skins
FACT - - People with dark skins have low levels of vitamin D
FACT - - People with light skins who have low vitamin D have health problems
OBSERVATION - - The health problems of whites with low level of vitamin D are similar to those with dark skins
CONCLUSION - - People with dark skins have more health problems due to low levels of vitamin D

Blacks die more often than whites of many diseases (they have less vitamin D) – 2012 contains the following summary

Cancer Facts & Figures for African Americans Cancer.org

  • “African Americans have the highest death rate and shortest survival of any racial and ethnic group in the US for most cancers”
  • Has a huge number of tables and charts, Note: Vitamin D is not mentioned

Leading Causes of Death as of March 2018

All Ages Death rateBlackWhiteRatio
Heart diseases 217 1711.27
Cancer 1991701.17
Cerebrovascular diseases51361.4
Diabetes 40 192.0

Rates per 100,000    Age adjusted   Non-Hispanic

see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=645
The more the African Ancestry, the lower the vitamin D level – July 2010

Power Range Weekly change
nmol per week
Age, years 1.000 22–62 −5.6
rs4911414, ASIP%%Sun sensitivity1.000 TT + GT/GGa −2.4
rs4911442, ASIP .998 AG/AAa 2.0
rs12896399, SCL24A4.985 TT + GT/GGa 1.6
Height cm 0.957 4.4
rs6475555, MTAP
0.953 AA + AG/GGa 1.2
rs16891982, SCL45A2
0.945 CC/GC + GGa 3.5
Sex 0.905 Female/male 1.8
Rs28777, SCL45A2 0.945 CC/CA/AAa −5.2
rs11614913, MIR196A29 0.878 TT + CT/CCa −1.1

Skin pigmentation is believed to contribute to the generally low serum 25-hydroxyvitamin D (25(OH)D) concentrations observed in darker-skinned persons. The influence of measured skin pigmentation on UVB-induced 25(OH)D increase was investigated together with 9 demographic and 13 genetic parameters (pigment SNPs).

Forty participants representing a wide range in measured skin pigmentation were exposed to identical UVB doses on identical body areas over nine weeks with weekly measurements of serum 25(OH)D.

This study took place in Denmark during winter, a period with negligible ambient UVB, so variation in 25(OH)D synthesis was not influenced by latitude, season, sun and clothing habits.

The increase in 25(OH)D concentration displayed considerable variation (range: 2.9 to 139 nmol L-1).
Constitutive and facultative skin pigmentation exerted separate influence on the variation of the UVB-induced linear 25(OH)D increase. However, this influence was statistically non-significant in the presence of separate significant pigment SNPs.

The variation in the 25(OH)D increase in the combined linear model was not explained by measured skin pigmentation but by sex, height, age and seven SNPs located in the ASIP, MTAP, MIR196A29 and Solute Carrier Family genes.

This linear model including individual intercepts and the 10 parameters influencing the slope explained 77.4% of the variation.

This study confirmed the influence of sex, age and height on 25(OH)D increase and found that pigment genes provided a better relation to UVB-induced 25(OH)D increase compared to the actual measured skin pigmentation. Therefore, only investigating skin pigmentation obscure other causal parameters for low 25(OH)D.

Created by admin. Last Modification: Saturday January 12, 2019 20:31:36 GMT-0000 by admin. (Version 9)
See any problem with this page? Report it (FINALLY WORKS)