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Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018

In utero exposure to extra vitamin D from food fortification and the risk of subsequent development of gestational diabetes: the D-tect study.

Nutr J. 2018 Nov 2;17(1):100. doi: 10.1186/s12937-018-0403-5.
Keller A1, Stougård M2, Frederiksen P2, Thorsteinsdottir F2, Vaag A3, Damm P4,5, Jacobsen R2,6, L Heitmann B2,7,8,9.


Margerine fortification with 50 IU of Vitamin D/100 grams was stopped in Denmark in June 1985. This study compared subsequent GD in the women born before and after that change

Fortification in Europe

Pages listed in BOTH of the categories Diabetes and Pregnancy

Some other D-Tect studies on reduction of Vitamin D fortification in Margerine

  • Extra vitamin D from fortification and the risk of preeclampsia: The D-tect Study. Jan 2018 oi: 10.1371/journal.pone.0191288 Free PDF
  • Prenatal exposure to vitamin D from fortified margarine and risk of fractures in late childhood: period and cohort results from 222 000 subjects in the D-tect observational study. March 2017 doi: 10.1017/S000711451700071X
  • Exposure to vitamin D from fortified margarine during fetal life and later risk of pre-eclampsia: the D-tect Study - March 2018 doi: 10.1017/S1368980017003135
  • Vitamin D fortification and seasonality of birth in type 1 diabetic cases: D-tect study. Feb 2016 doi: 10.1017/S2040174415007849

 Download the PDF from VitaminDWiki

The primary aim of this study was to assess whether exposure during fetal life to extra vitamin D from food fortification was associated with a reduction in the risk of subsequently developing gestational diabetes mellitus (GDM). Furthermore, we examined whether the effect of the vitamin D from fortification differed by women's season of birth.

This semi-ecological study is based on the cancellation in 1985 of the mandatory policy to fortify margarine with vitamin D in Denmark, with inclusion of entire national adjacent birth cohorts either exposed or unexposed to extra vitamin D in utero. The identification of GDM cases later in life among both exposure groups was based on the Danish national health registers. Logistic regression analyses generating odds ratios (ORs) and 95% confidence intervals (95% CIs) were performed.

Women who were prenatally exposed to the extra vitamin D from fortification tended to have a lower risk of subsequently developing GDM than unexposed women (OR 0.87, 95%CI 0.74,1.02, P = 0.08). When analyses were stratified by women's season of birth, exposed women born in spring had a lower risk of developing GDM compared to unexposed subjects (OR 0.68, 95%CI 0.50,0.94, p = 0.02).

This study suggests that prenatal exposure to extra vitamin D from mandatory fortification may lower the risk of developing gestational diabetes among spring-born women.

TRIAL REGISTRATION: This study is part of the D-tect project, which is registered on clinicaltrials.gov: NCT03330301 .

Created by admin. Last Modification: Friday June 14, 2019 15:50:46 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
12129 GD 50 IU.pdf PDF 2018 admin 14 Jun, 2019 15:09 401.24 Kb 33
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