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Vitamin D and neurocognitive function – Holick Oct 2022


Vitamin D and neurocognitive function

Clinical Interventions in Aging, , 559-568, DOI: 10.2147/CIA.S51785 https://doi.org/10.2147/CIA.S51785
Mathias Schlögl & Michael F Holick
'University Center for Medicine of Aging Basel, University of Basel, Basel, Switzerland; 2Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA

Video abstract
In recent years, emerging evidence has linked vitamin D not only to its known effects on calcium and bone metabolism, but also to many chronic illnesses involving neurocognitive decline. The importance of vitamin D3 in reducing the risk of these diseases continues to increase due to the fact that an increasing portion of the population in developed countries has a significant vitamin D deficiency. The older population is at an especially high risk for vitamin D deficiency due to the decreased cutaneous synthesis and dietary intake of vitamin D. Recent studies have confirmed an association between cognitive impairment, dementia, and vitamin D deficiency. There is a need for well-designed randomized trials to assess the benefits of vitamin D and lifestyle interventions in persons with mild cognitive impairment and dementia.


PDF Table of Contents includes:

Vitamin D receptor in the brain
Vitamin D and aging
Malnutrition in the elderly
Prevalence of vitamin D deficiency
Vitamin D and neurocognitive functioning
Vitamin D and mild cognitive impairment
Vitamin D, Alzheimer’s disease, and vascular dementia


Appears to be very similar to: Vitamin D and neurocognitive function – Holick April 2014

49 VitaminDWiki pages with HOLICK in title (as of Oct 2022)

This list is automatically updated

Items found: 52
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VitaminDWiki - Overview Alzheimer's-Cognition and Vitamin D contains


VitaminDWiki - Cognitive category cpntains

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items

373 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (7 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (49 studies), Intervention (19 studies), Meta-analyses (22 studies), Depression (23 studies), Parkinson's (22 studies)
Click here for details

Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023

Types of evidence that Vitamin D helps brain problems - 2014
https://vitamindwiki.com/tiki-index.php?page_id=8392


94 VitaminDWiki pages with BRAIN in title (as of Oct 2022)

This list is automatically updated

Items found: 107
Title Modified
Omega-3 is important for Brain Health during all phases of life – Aug 2018 08 Dec, 2018
Poor blood-brain barrier following stroke if low vitamin D (in rats) – RCT Feb 2019 01 Dec, 2018
Amyloid brain plaque both prevented and removed by high vitamin D (in mice) – Aug 2018 23 Nov, 2018
Perhaps drugs such as inhaled vitamin D can get directly to the brain – March 2018 19 Nov, 2018
Brain injury disability associated with lower vitamin D – Oct 2018 20 Oct, 2018
Brain cancer in 175 countries related to low UVB and low vitamin D – Oct 2010 03 Oct, 2018
Autistics and Schizophrenics have 3X lower Vitamin B12 levels in the brain – Jan 2016 01 Oct, 2018
The Role of Vitamin D in Brain Health: A Mini Literature Review – Sept 2018 15 Sep, 2018
Brain is helped by Omega-3 during all phases of life – Aug 2018 21 Aug, 2018
Following strokes, brain scans (MRI) 3X worse in those having low vitamin D – July 2018 25 Jul, 2018
Smaller brains (Intracranial Volume) associated with lower vitamin D – July 2018 21 Jul, 2018
Omega-3: An Intelligent Decision for Brain Nutrition (book chapter) April 2018 24 Apr, 2018
5 Traumatic brain injuries resulted in 2.8 X increased risk of dementia – April 2018 11 Apr, 2018
Woolly mammoth brains, like mammal brains, were a good source of Omega-3 – March 2018 07 Apr, 2018
ADHD 4 year-olds – smaller brain regions proportional to ADHD severity – March 2018 26 Mar, 2018
60 percent of preemies have brain damage from lack of brain Oxygen, which is associated with low vitamin D – Feb 2018 22 Feb, 2018
Brain Tumor surgery – will previous injection of 300,000 IU Vitamin D help – RCT 2018 29 Dec, 2017
Off topic: Brain Plasticity (best way to exercise your brain) – Interview Dec 2012 08 Dec, 2017
Dementia risk reduced 29 percent by just 10 hours of computer brain plasticity training – RCT Dec 2017 08 Dec, 2017
Nerve growth and survival depends on BDNF (Brain-Derived Neurotrophic Factor), which is associated with Vitamin D 19 Nov, 2017
Brain may deal with all forms of Vitamin D (rat brain) – Sept 2017 06 Nov, 2017
Mild Traumatic Brain Injury prevented with Omega-3, Resveratrol, etc (in rats) – Oct 2017 10 Oct, 2017
Lymphatic system discovered in brain (what about Multiple Sclerosis, Alzheimer’s, Omega-3 and Vitamin D) – Oct 2017 07 Oct, 2017
Active form of vitamin D directly protects the blood–brain barrier in multiple sclerosis – Aug 2017 26 Aug, 2017
300,000 IU Vitamin D injection before brain tumor surgery – RCT to finish Dec 2017 20 Aug, 2017
Mild Traumatic Brain Injury reduced by Vitamin D – May 2014 07 Aug, 2017
Infants getting 1 g of Omega-3 for 12 weeks got better brains – RCT March 2017 18 Mar, 2017
Sustained brain attention appears to vary with vitamin D levels – March 2016 21 Jan, 2017
Glioma (brain, spinal cancer) 40 percent less likely if male vitamin D levels were high 15 years earlier – Aug 2015 25 Dec, 2016
Cognitive decline after traumatic brain injury reduced by Omega-3 (mice) – Nov 2016 06 Dec, 2016
Traumatic brain injury treated by Vitamin D Progesterone Omega-3 and glutamine – May 2013 11 Sep, 2016
Zika causes brain problems in adult (mice) having poor immune systems– Nov 2016 22 Aug, 2016
Magnesium L-Threonate – tiny amount more bioavailable to brain but far more expensive– June 2016 16 May, 2016
Malaria in mice brains, and associated inflammation, prevented by Vitamin D intervention – July 2014 01 May, 2016
Fructose altered hundreds of brain genes (in rats) unless also take Omega-3 – April 2016 01 May, 2016
High-fructose diet slows recovery from brain injury - TBI, rats - Oct 2015 01 May, 2016
Benefits of Omega-3 on brain development 30 Apr, 2016
Football Brain injuries prevented by Omega-3 – RCT Jan 2016 08 Feb, 2016
Traumatic Brain Injury in military - vitamin D - 2014 08 Feb, 2016
Magnesium may be an important way to treat brain trauma 12 Oct, 2015
Less vitamin D, bigger brain - humans and animals - Jan 2015 11 Aug, 2015
Cognitively impaired brain atrophy was slowed 40 percent by Omega-3 and B vitamins – RCT July 2015 14 Jul, 2015
Fewer white spots in MRI brain scans if had more vitamin D – Jan 2014 31 May, 2015
Parkinsons' disease and MRI white matter in brain 25 Feb, 2015
Brains of seniors had 60 percent more white matter abnormalities if low vitamin D – March 2015 25 Feb, 2015
Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012 03 Jan, 2015
Vitamin D improved brains in aging rats – Sept 2014 03 Oct, 2014
33 percent more white matter abnormality in brain (periventricular WMA) if low vitamin D – July 2014 15 Jul, 2014
Hypothesis: Chemo brain and other cognitive impairements are associated with low vitamin D 09 Jul, 2014
Brain (Alzheimer’s) worked better with Vitamin D intervention – meta-analysis July 2013 05 May, 2014
Low vitamin D is associated with larger brain – Feb 2014 16 Feb, 2014
Low vitamin D is bad for the rat brain (and probably human brain) – Dec 2013 19 Jan, 2014
Low vitamin D associated with brain atrophy in MS – April 2010 19 Jan, 2014
Brain lesions might be associated with vitamin D deficiency – March 2012 19 Jan, 2014
Autism has different causes but same inflammation in brain in half of autistics – May 2011 13 Jul, 2013
Parkinson disease 2X more likely after brain injury – which usually reduces vitamin D – Nov 2012 13 Nov, 2012
If less than 20 ng then 2X more likely to be fatigued after brain injury - April 2010 05 Nov, 2011
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VitaminDWiki - 16 studies in both Cognitive and Vitamin D Receptor categories

This list is automatically updated


It appears that more Vitamin D gets to the brain when it is inhaled thru the nose


Study References
  1. Holick MF Vitamin D deficiency, NEngl J Med. 2007;357(3): 266-281.
  2. Dobs AS, Levine MA, Margolis S. Effects of pravastatin, a new HMG- CoA reductase inhibitor, on vitamin D synthesis in man. Metabolism. 1991;40(5):524-528.
  3. Godar DE, Pope SJ, Grant WB, Holick MF. Solar UV doses of adult Americans and vitamin D(3) production. Dermatoendocrinol. 2011;3(4):243-250.
  4. Holick MF. Optimal vitamin D status for the prevention and treatment of osteoporosis. Drugs Aging. 2007;24(12):1017-1029.
  5. Holick MF. Evolution and function of vitamin D. Recent Results Cancer Res. 2003;164:3-28.
  6. Lehmann B, Tiebel O, Meurer M. Expression of vitamin D3 25-hydroxylase (CYP27) mRNA after induction by vitamin D3 or UVB radiation in keratinocytes of human skin equivalents - a preliminary study. Arch Dermatol Res. 1999;291(9):507-510.
  7. Bikle DD, Halloran BP, Riviere JE. Production of 1,25 dihydroxyvitamin D3 by perfused pig skin. J Invest Dermatol. 1994;102(5):796-798.
  8. Seifert M, Tilgen W, Reichrath J. Expression of 25-hydroxyvitamin D-1alpha-hydroxylase (lalphaOHase, CYP27B1) splice variants in HaCaT keratinocytes and other skin cells: modulation by culture conditions and UV-B treatment in vitro. Anticancer Res. 2009;29(9): 3659-3667.
  9. Fu GK, Lin D, Zhang MY, et al. Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Mol Endocrinol. 1997;11(13):1961—1970.
  10. Lehmann B, Genehr T, Knuschke P, Pietzsch J, Meurer M. UVB-induced conversion of 7-dehydrocholesterol to 1alpha, 25-dihydroxyvitamin D3 in an in vitro human skin equivalent model. J Invest Dermatol. 2001;117(5):1179—1185.
  11. Mangelsdorf DJ, Thummel C, Beato M, et al. The nuclear receptor superfamily: the second decade. Cell. 1995;83(6):835—839.
  12. Sutherland MK, Somerville MJ, Yoong LK, Bergeron C, Haussler MR, McLachlan DR. Reduction of vitamin D hormone receptor mRNA levels in Alzheimer as compared to Huntington hippocampus: correlation with calbindin-28k mRNA levels. Brain Res Mol Brain Res. 1992;13(3):239—250.
  13. Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. JChem Neuroanat. 2005;29(1):21-30.
  14. Dhikav V Anand K. Potential predictors of hippocampal atrophy in Alzheimer’s disease. Drugs Aging. 2011;28(1):1-11.
  15. Mu Y, Gage FH. Adult hippocampal neurogenesis and its role in Alzheimer’s disease. Mol Neurodegener. 2011;6:85.
  16. Fotuhi M, Do D, Jack C. Modifiable factors that alter the size of the hippocampus with ageing. Nat Rev Neurol. 2012;8(4):189-202.
  17. Calabresi P, Castrioto A, Di Filippo M, Picconi B. New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson’s disease. Lancet Neurol. 2013;12(8): 811-821.
  18. Nimitphong H, Holick MF. Vitamin D, neurocognitive functioning and immunocompetence. Curr Opin Clin Nutr Metab Care. 2011; 14(1):7-14.
  19. Beydoun MA, Ding EL, Beydoun HA, Tanaka T, Ferrucci L, Zonderman AB. Vitamin D receptor and megalin gene polymorphisms and their associations with longitudinal cognitive change in US adults. Am J Clin Nutr. 2012;95(1):163-178.
  20. Kuningas M, Mooijaart SP, Jolles J, Slagboom PE, Westendorp RG, van Heemst D. VDR gene variants associate with cognitive function and depressive symptoms in old age. Neurobiol Aging. 2009;30(3): 466-473.
  21. Luedecking-Zimmer E, DeKosky ST, Nebes R, Kamboh MI. Association of the 3' UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer’s disease. Am J Med Genet BNeuropsychiatr Genet. 2003;117B(1):114-117.
  22. Gezen-Ak D, Dursun E, Ertan T, et al. Association between vitamin D receptor gene polymorphism and Alzheimer’s disease. Tohoku J Exp Med. 2007;212(3):275-282.
  23. Lehmann DJ, Refsum H, Warden DR, Medway C, Wilcock GK, Smith AD. The vitamin D receptor gene is associated with Alzheimer’s disease. Neurosci Lett. 2011;504(2):79-82.
  24. Gezen-Ak D, Dursun E, Bilgiç B, et al. Vitamin D receptor gene haplotype is associated with late-onset Alzheimer’s disease. Tohoku J Exp Med. 2012;228(3):189-196.
  25. Kim JS, Kim YI, Song C, et al. Association of vitamin D receptor gene polymorphism and Parkinson’s disease in Koreans. J Korean Med Sci. 2005;20(3):495-98.
  26. Butler MW, Burt A, Edwards TL, et al. Vitamin D receptor gene as a candidate gene for Parkinson disease. Ann Hum Genet. 2011;75(2): 201-210.
  27. Han X, Xue L, Li Y, Chen B, Xie A. Vitamin D receptor gene polymorphism and its association with Parkinson’s disease in Chinese Han population. Neurosci Lett. 2012;525(1):29-33.
  28. Lv Z, Tang B, Sun Q, Yan X, Guo J. Association study between vitamin d receptor gene polymorphisms and patients with Parkinson disease in Chinese Han population. Int J Neurosci. 2013;123(1):60—64.
  29. Torok R, Torok N, Szalardy L, et al. Association of vitamin D receptor gene polymorphisms and Parkinson’s disease in Hungarians. Neurosci Lett. 2013;551:70-74.
  30. Krizova L, Kollar B, Jezova D, Turcani P. Genetic aspects of vitamin D receptor and metabolism in relation to the risk of multiple sclerosis. Gen PhysiolBiophys. Epub September 26, 2013.
  31. MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76(4):1536-1538.
  32. Harris SS, Dawson-Hughes B. Plasma vitamin D and 25OHD responses of young and old men to supplementation with vitamin D3. J Am Coll Nutr. 2002;21(4):357-362.
  33. Gallagher JC, Rapuri P, Smith L. Falls are associated with decreased renal function and insufficient calcitriol production by the kidney. J Steroid Biochem Mol Biol. 2007;103(3-5):610-613.
  34. Armbrecht HJ, Zenser TV Davis BB. Effect of age on the conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 by kidney of rat. J Clin Invest. 1980;66(5):1118-1123.
  35. Need AG, Morris HA, Horowitz M, Nordin C. Effects of skin thickness, age, body fat, and sunlight on serum 25-hydroxyvitamin D. Am J Clin Nutr. 1993;58(6):882-885.
  36. Holick MF, Matsuoka LY, Wortsman J. Age, vitamin D, and solar ultraviolet. Lancet. 1989;2(8671):1104-1105.
  37. Gau JT. Prevalence of vitamin D deficiency/insufficiency practice patterns in nursing homes. J Am Med Dir Assoc. 2010;11(4):296.
  38. Morley JE. Vitamin d redux. J Am Med Dir Assoc. 2009;10(9): 591-592.
  39. Braddy KK, Imam SN, Palla KR, Lee TA. Vitamin d deficiency/insufficiency practice patterns in a veterans health administration longterm care population: a retrospective analysis. J Am Med Dir Assoc. 2009;10(9):653-657.
  40. Perry HM, Horowitz M, Morley JE, et al. Longitudinal changes in serum 25-hydroxyvitamin D in older people. Metabolism. 1999;48(8): 1028-1032.
  41. Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752-762.
  42. Welge-Lüssen A. Ageing, neurodegeneration, and olfactory and gustatory loss. B-ENT. 2009;5 Suppl 13:129-132.
  43. Methven L, Allen VJ, Withers CA, Gosney MA. Ageing and taste. Proc Nutr Soc. 2012;71(4):556-565.
  44. Guiglia R, Musciotto A, Compilato D, et al. Aging and oral health: effects in hard and soft tissues. Curr Pharm Des. 2010;16(6):619-630.
  45. Zadak Z, Hyspler R, Ticha A, Vlcek J. Polypharmacy and malnutrition. Curr Opin Clin Nutr Metab Care. 2013;16(1):50-55.
  46. Tamura BK, Bell CL, Masaki KH, Amella EJ. Factors associated with weight loss, low BMI, and malnutrition among nursing home patients: a systematic review of the literature. J Am Med Dir Assoc. 2013;14(9): 649-655.
  47. van Bokhorst-de van der Schueren MA, Lonterman-Monasch S, de Vries OJ, Danner SA, Kramer MH, Muller M. Prevalence and determinants for malnutrition in geriatric outpatients. Clin Nutr. 2013;32(6):1007-1011.
  48. Roqué M, Salvà A, Vellas B. Malnutrition in community-dwelling adults with dementia (NutriAlz Trial). J Nutr Health Aging. 2013;17(4):295-299.
  49. Ikeda M, Brown J, Holland AJ, Fukuhara R, Hodges JR. Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2002;73(4): 371-376.
  50. Manthorpe J, Watson R. Poorly served? Eating and dementia. J Adv Nurs. 2003;41(2):162-169.
  51. Greenwood CE, Tam C, Chan M, Young KW, Binns MA, van Reekum R. Behavioral disturbances, not cognitive deterioration, are associated with altered food selection in seniors with Alzheimer’s disease. J Gerontol A Biol Sci Med Sci. 2005;60(4): 499-505.
  52. Allen VJ, Methven L, Gosney MA. Use of nutritional complete supplements in older adults with dementia: Systematic review and metaanalysis of clinical outcomes. Clin Nutr. Epub Mar 28, 2013.
  53. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-1930.
  54. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academies Press (US); 2011.
  55. Hagenau T, Vest R, Gissel TN, et al. Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis. Osteoporos Int. 2009;20(1):133-140.
  56. Wahl DA, Cooper C, Ebeling PR, et al. A global representation of vitamin D status in healthy populations. Arch Osteoporos. 2012; 7(1-2): 155-172.
  57. Hossein-Nezhad A, Holick MF. Vitamin d for health: a global perspective. Mayo Clin Proc. 2013;88(7):720-755.
  58. van der Wielen RP, Lowik MR, van den Berg H, et al. Serum vitamin D concentrations among elderly people in Europe. Lancet. 1995;346(8969):207-210.
  59. Ganji V Zhang X, Tangpricha V Serum 25-hydroxyvitamin D concentrations and prevalence estimates of hypovitaminosis D in the US population based on assay-adjusted data. J Nutr. 2012;142(3): 498-507.
  60. Valtuena J, Gracia-Marco L, Huybrechts I, et al; Helena Study Group. Cardiorespiratory fitness in males, and upper limbs muscular strength in females, are positively related with 25-hydroxyvitamin D plasma concentrations in European adolescents: the HELENA study. QJM. 2013;106(9):809-821.
  61. Anderson JL, May HT, Horne BD, et al; Intermountain Heart Collaborative (IHC) Study Group. Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population. Am J Cardiol. 2010;106(7): 963-968.
  62. Kienreich K, Tomaschitz A, Verheyen N, et al. Vitamin D and cardiovascular disease. Nutrients. 2013;5(8):3005-3021.
  63. Chabas JF, Alluin O, Rao G, et al. Vitamin D2 potentiates axon regeneration. J Neurotrauma. 2008;25(10):1247-1256.
  64. Brown J, Bianco JI, McGrath JJ, Eyles DW. 1,25-dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons. Neurosci Lett. 2003;343(2):139-143.
  65. Marini F, Bartoccini E, Cascianelli G, et al. Effect of 1alpha, 25-dihydroxyvitamin D3 in embryonic hippocampal cells. Hippocampus. 2010;20(6):696-705.
  66. Brewer LD, Thibault V, Chen KC, Langub MC, Landfield PW, Porter NM. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. J Neurosci. 2001;21(1):98-108.
  67. Ibi M, Sawada H, Nakanishi M, et al. Protective effects of 1 alpha, 25-(OH)(2)D(3) against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture. Neuropharmacology. 2001;40(6):761-771.
  68. Kroncke KD, Klotz LO, Suschek CV Sies H. Comparing nitrosative versus oxidative stress toward zinc finger-dependent transcription. Unique role for NO. J Biol Chem. 2002;277(15):13294-13301.
  69. Garcion E, Sindji L, Montero-Menei C, Andre C, Brachet P, Darcy F. Expression of inducible nitric oxide synthase during rat brain inflammation: regulation by 1,25-dihydroxyvitamin D3. Glia. 1998;22(3):282-294.
  70. Chen KB, Lin AM, Chiu TH. Systemic vitamin D3 attenuated oxidative injuries in the locus coeruleus of rat brain. Ann N Y Acad Sci. 2003;993:313-324; discussion 345-349.
  71. Lin AM, Fan SF, Yang DM, Hsu LL, Yang CH. Zinc-induced apoptosis in substantia nigra of rat brain: neuroprotection by vitamin D3. Free Radic Biol Med. 2003;34(11):1416-1425.
  72. Wion D, MacGrogan D, Neveu I, Jehan F, Houlgatte R, Brachet P. 1,25-Dihydroxyvitamin D3 is a potent inducer of nerve growth factor synthesis. J Neurosci Res. 1991;28(1):110-114.
  73. Neveu I, Naveilhan P, Baudet C, Brachet P, Metsis M. 1,25-dihydroxyvitamin D3 regulates NT-3, NT-4 but not BDNF mRNA in astrocytes. Neuroreport. 1994;6(1):124-126.
  74. Neveu I, Naveilhan P, Jehan F, et al. 1,25-dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells. Brain Res Mol Brain Res. 1994;24(1 ?):70-76.
  75. Musiol IM, Feldman D. 1,25-dihydroxyvitamin D3 induction of nerve growth factor in L929 mouse fibroblasts: effect of vitamin D receptor regulation and potency of vitamin D3 analogs. Endocrinology. 1997;138(1):12-18.
  76. Veenstra TD, Fahnestock M, Kumar R. An AP-1 site in the nerve growth factor promoter is essential for 1,25-dihydroxyvitamin D3- mediated nerve growth factor expression in osteoblasts. Biochemistry. 1998;37(17):5988-5994.
  77. Naveilhan P, Neveu I, Wion D, Brachet P 1,25-Dihydroxyvitamin D3, an inducer of glial cell line-derived neurotrophic factor. Neuroreport. 1996;7(13):2171-2175.
  78. Masoumi A, Goldenson B, Ghirmai S, et al. 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer’s disease patients. J Alzheimers Dis. 2009;17(3):703-717.
  79. Mizwicki MT, Liu G, Fiala M, et al. 1a,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-p phagocytosis and inflammation in Alzheimer’s disease patients. J Alzheimers Dis. 2013;34(1):155-170.
  80. Pludowski P, Holick MF, Pilz S, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev. 2013;12(10):976-989.
  81. Witham MD, Nadir MA, Struthers AD. Effect of vitamin D on blood pressure: a systematic review and meta-analysis. J Hypertens. 2009;27(10):1948-1954.
  82. Pilz S, Tomaschitz A, Mârz W, et al. Vitamin D, cardiovascular disease and mortality. Clin Endocrinol (Oxf). 2011;75(5):575-584.
  83. Muscogiuri G, Sorice GP, Ajjan R, et al. Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives. Nutr Metab Cardiovasc Dis. 2012;22(2):81-87.
  84. Wang L, Song Y, Manson JE, et al. Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies. Circ Cardiovasc Qual Outcomes. 2012;5(6):819-829.
  85. Brondum-Jacobsen P, Nordestgaard BG, Schnohr P, Benn M. 25-hydroxyvitamin D and symptomatic ischemic stroke: an original study and meta-analysis. Ann Neurol. 2013;73(1):38-47.
  86. Gunta SS, Thadhani RI, Mak RH. The effect of vitamin D status on risk factors for cardiovascular disease. Nat Rev Nephrol. 2013;9(6):337-347.
  87. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest. 2002;110(2):229-238.
  88. Li YC. Vitamin D regulation of the renin-angiotensin system. J Cell Biochem. 2003;88(2):327-331.
  89. Zhou C, Lu F, Cao K, Xu D, Goltzman D, Miao D. Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice. Kidney Int. 2008;74(2): 170-179.
  90. Forman JP, Williams JS, Fisher ND. Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humans. Hypertension. 2010;55(5):1283-1288.
  91. Sanna B, Brandt EB, Kaiser RA, et al. Modulatory calcineurin- interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Proc Natl Acad Sci U S A. 2006;103(19):7327-7332.
  92. Bodyak N, Ayus JC, Achinger S, et al. Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals. Proc Natl Acad Sci U S A. 2007;104(43): 16810-16815.
  93. Chen S, Law CS, Grigsby CL, et al. Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation. 2011;124(17):1838-1847.
  94. Tarcin O, Yavuz DG, Ozben B, et al. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab. 2009;94(10):4023-4030.
  95. Caprio M, Mammi C, Rosano GM. Vitamin D: a novel player in endothelial function and dysfunction. Arch Med Sci. 2012;8(1): 4-5.
  96. Sypniewska G, Pollak J, Strozecki P, et al. 25-Hydroxyvitamin D, biomarkers of endothelial dysfunction and subclinical organ damage in adults with hypertension. Am J Hypertens. Epub September 16, 2013.
  97. Aihara K, Azuma H, Akaike M, et al. Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice. J Biol Chem. 2004;279(34):35798-35802.
  98. Watson KE, Abrolat ML, Malone LL, et al. Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation. 1997;96(6):1755-1760.
  99. de Boer IH, Kestenbaum B, Shoben AB, Michos ED, Sarnak MJ, Siscovick DS. 25-hydroxyvitamin D levels inversely associate with risk for developing coronary artery calcification. J Am Soc Nephrol. 2009;20(8):1805-1812.
  100. Bos D, Vernooij MW, Elias-Smale SE, et al. Atherosclerotic calcification relates to cognitive function and to brain changes on magnetic resonance imaging. Alzheimers Dement. 2012;8(Suppl 5): S104-S111.
  101. Yarchoan M, Xie SX, Kling MA, et al. Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias. Brain. 2012;135(Pt 12):3749-3756.
  102. Roher AE, Tyas SL, Maarouf CL, et al. Intracranial atherosclerosis as a contributing factor to Alzheimer’s disease dementia. Alzheimers Dement. 2011;7(4):436^44.
  103. Vidal JS, Sigurdsson S, Jonsdottir MK, et al. Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study. Stroke. 2010;41(5):891-897.
  104. Knopman D, Boland LL, Mosley T, et al; Atherosclerosis Risk in Communities (ARIC) Study Investigators. Cardiovascular risk factors and cognitive decline in middle-aged adults. Neurology. 2001;56(1):42-48.
  105. Goldstein FC, Levey AI, Steenland NK. High blood pressure and cognitive decline in mild cognitive impairment. J Am Geriatr Soc. 2013;61(1):67-73.
  106. Kivipelto M, Helkala EL, Hânninen T, et al. Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study. Neurology. 2001;56(12):1683-1689.
  107. Reitz C, Tang MX, Manly J, Mayeux R, Luchsinger JA. Hypertension and the risk of mild cognitive impairment. Arch Neurol. 2007;64(12):1734-1740.
  108. Launer LJ, Ross GW, Petrovitch H, et al. Midlife blood pressure and dementia: the Honolulu-Asia aging study. Neurobiol Aging. 2000;21(1):49-55.
  109. Yamada M, MimoriY, Kasagi F, Miyachi T, Ohshita T, Sasaki H. Incidence and risks of dementia in Japanese women: Radiation Effects Research Foundation Adult Health Study. J Neurol Sci. 2009;283(1-2):57-61.
  110. Qiu C, Winblad B, Fratiglioni L. The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol. 2005;4(8):487-499.
  111. Gorelick PB, Scuteri A, Black SE, et al; American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and Anesthesia. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke. 2011;42(9):2672-2713.
  112. Petersen RC. Clinical Practice. Mild cognitive impairment. N Engl J Med. 2011;364(23):2227-2234.
  113. Ganguli M, Snitz BE, Saxton JA, et al. Outcomes of mild cognitive impairment by definition: a population study. Arch Neurol. 2011;68(6):761-767.
  114. Annweiler C, Schott AM, Berrut G, et al. Vitamin D and ageing: neurological issues. Neuropsychobiology. 2010;62(3):139-150.
  115. Annweiler C, Allali G, Allain P, et al. Vitamin D and cognitive performance in adults: a systematic review. Eur JNeurol. 2009;16(10): 1083-1089.
  116. Grant WB. Does vitamin D reduce the risk of dementia? J Alzheimers Dis. 2009;17(1):151-159.
  117. Etgen T, Sander D, Bickel H, Sander K, Forstl H. Vitamin D deficiency, cognitive impairment and dementia: a systematic review and metaanalysis. Dement Geriatr Cogn Disord. 2012;33(5):297-305.
  118. Llewellyn DJ, Langa KM, Lang IA. Serum 25-hydroxyvitamin D concentration and cognitive impairment. J Geriatr Psychiatry Neurol. 2009;22(3):188-195.
  119. Balion C, Griffith LE, Strifler L, et al. Vitamin D, cognition, and dementia: a systematic review and meta-analysis. Neurology. 2012;79(13):1397-1405.
  120. Defina PA, Moser RS, Glenn M, Lichtenstein JD, Fellus J. Alzheimer’s disease clinical and research update for health care practitioners. JAgingRes. 2013;2013:207178.
  121. Ferri CP, Prince M, Brayne C, et al; Alzheimer’s Disease International. Global prevalence of dementia: a Delphi consensus study. Lancet. 2005;366(9503):2112-2117.
  122. Chui HC, Victoroff JI, Margolin D, Jagust W, Shankle R, Katzman R. Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer’s Disease Diagnostic and Treatment Centers. Neurology. 1992;42(3 Pt 1):473-480.
  123. Román GC, Tatemichi TK, Erkinjuntti T, et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology. 1993;43(2):250-260.
  124. Hachinski V. Vascular dementia: a radical redefinition. Dementia. 1994;5(3 ?):130-132.
  125. Plassman BL, Langa KM, Fisher GG, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology. 2007;29(1-2):125-132.
  126. Langbaum JB, Fleisher AS, Chen K, et al. Ushering in the study and treatment of preclinical Alzheimer disease. Nat Rev Neurol. 2013;9(7):371-381.
  127. Wiesmann M, Kiliaan AJ, Claassen JA. Vascular aspects of cognitive impairment and dementia. J Cereb Blood Flow Metab. Epub September 11, 2013.
  128. Iadecola C. The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathol. 2010;120(3):287-296.
  129. Neuropathology Group. Medical Research Council Cognitive Function and Aging Study. Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Lancet. 2001;357(9251):169-175.
  130. White L, Small BJ, Petrovitch H, et al. Recent clinical-pathologic research on the causes of dementia in late life: update from the Honolulu- Asia Aging Study. J Geriatr Psychiatry Neurol. 2005;18(4): 224-227.
  131. Sonnen JA, Larson EB, Crane PK, et al. Pathological correlates of dementia in a longitudinal, population-based sample of aging. Ann Neurol. 2007;62(4):406-413.
  132. Schneider JA, Aggarwal NT, Barnes L, Boyle P, Bennett DA. The neuropathology of older persons with and without dementia from community versus clinic cohorts. J Alzheimers Dis. 2009;18(3):691-701.
  133. Esiri MM, Nagy Z, Smith MZ, Barnetson L, Smith AD. Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer’s disease. Lancet. 1999;354(9182):919-920.
  134. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression ofAlzheimer disease. The Nun Study, JAMA. 1997;277(10):813-817.
  135. Schneider JA, Wilson RS, Bienias JL, Evans DA, Bennett DA. Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology. Neurology. 2004;62(7):1148-1155.
  136. Schneider JA, Arvanitakis Z, Bang W, Bennett DA. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology. 2007;69(24):2197-2204.
  137. Zekry D, Duyckaerts C, Belmin J, Geoffre C, Moulias R, Hauw JJ. Alzheimer’s disease and brain infarcts in the elderly. Agreement with neuropathology. J Neurol. 2002;249(11):1529-1534.
  138. Buell JS, Dawson-Hughes B, Scott TM, et al. 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology. 2010;74(1):18-26.
  139. Annweiler C, Fantino B, Le Gall D, Schott AM, Berrut G, Beauchet O. Severe vitamin D deficiency is associated with advanced- stage dementia in geriatric inpatients. J Am Geriatr Soc. 2011;59(1): 169-171.
  140. Annweiler C, Rolland Y, Schott AM, et al. Higher vitamin D dietary intake is associated with lower risk of Alzheimer’s disease: a 7-year follow-up. J Gerontol A Biol Sci Med Sci. 2012;67(11): 1205-1211.
  141. Annweiler C, Llewellyn DJ, Beauchet O. Low serum vitamin D concentrations in Alzheimer’s disease: a systematic review and metaanalysis. J Alzheimers Dis. 2013;33(3):659-674.
  142. Barnard K, Colon-Emeric C. Extraskeletal effects of vitamin D in older adults: cardiovascular disease, mortality, mood, and cognition. Am J Geriatr Pharmacother. 2010;8(1):4-33.
  143. Annweiler C, Montero-Odasso M, Llewellyn DJ, Richard-Devantoy S, Duque G, Beauchet O. Meta-analysis of memory and executive dysfunctions in relation to vitamin D. J Alzheimers Dis. 2013;37(1): 147-171.
  144. van der Schaft J, Koek HL, Dijkstra E, Verhaar HJ, van der Schouw YT, Emmelot-Vonk MH. The association between vitamin D and cognition: a systematic review. Ageing Res Rev. Epub May 29, 2013.
  145. Llewellyn DJ, Lang IA, Langa KM, et al. Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med. 2010;170(13): 1135-1141.
  146. Slinin Y, Paudel ML, Taylor BC, et al; Osteoporotic Fractures in Men (MrOS) Study Research Group. 25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men. Neurology. 2010;74(1):33-41.
  147. Slinin Y, Paudel M, Taylor BC, et al; Study of Osteoporotic Fractures Research Group. Association between serum 25(OH) vitamin D and the risk of cognitive decline in older women. J Gerontol A Biol Sci Med Sci. 2012;67(10):1092-1098.


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