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Vitamin D and chronic kidney disease – July 2014

Korean J Intern Med. Jul 2014; 29(4): 416–427.
Published online Jun 27, 2014. doi: 10.3904/kjim.2014.29.4.416
PMCID: PMC4101586
Chang Seong Kim and Soo Wan Kim

Chronic kidney disease (CKD) has been recognized as a significant global health problem because of the increased risk of total and cardiovascular morbidity and mortality. Vitamin D deficiency or insufficiency is common in patients with CKD, and serum levels of vitamin D appear to have an inverse correlation with kidney function. Growing evidence has indicated that vitamin D deficiency may contribute to deteriorating renal function, as well as increased morbidity and mortality in patients with CKD. Recent studies have suggested that treatment with active vitamin D or its analogues can ameliorate renal injury by reducing fibrosis, apoptosis, and inflammation in animal models; this treatment also decreases proteinuria and mortality in patients with CKD. These renoprotective effects of vitamin D treatment are far beyond its classical role in the maintenance of bone and mineral metabolism, in addition to its pleiotropic effects on extra-mineral metabolism. In this review, we discuss the altered metabolism of vitamin D in kidney disease, and the potential renoprotective mechanisms of vitamin D in experimental and clinical studies. In addition, issues regarding the effects of vitamin D treatment on clinical outcomes are discussed.


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Note: GFR = Glomerular Filtration Rate


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Vitamin D and chronic kidney disease – July 2014        
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4751 CKD Dec 2014.jpg admin 18 Dec, 2014 248.66 Kb 1647
4750 CKD 2014.pdf admin 18 Dec, 2014 70.81 Kb 1087
4191 CKD trials.jpg admin 26 Jul, 2014 286.76 Kb 2724
4190 CKD F1.jpg admin 26 Jul, 2014 65.65 Kb 7952
4189 CKD July 2014.pdf admin 26 Jul, 2014 471.20 Kb 820