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Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022

Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism—A Systematic Review

Nutrients 2022, 14(17), 3519; https://doi.org/10.3390/nu14173519
by Alessio Danilo Inchingolo et all

Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin have recently received the most attention among these molecules due to their documented antioxidant effects. The review aims to investigate the effects of these molecules on bone metabolism and their role in several diseases such as osteopenia and osteoporosis, bone tumours, and periodontitis. The PubMed/Medline, Web of Science, Google Scholar, Scopus, Cochrane Library, and Embase electronic databases were searched for papers in line with the study topic. According to an English language restriction, the screening period was from January 2012 to 3 July 2022, with the following Boolean keywords: (“resveratrol” AND “bone”); (“curcumin” AND “bone”); (“quercetin” AND “bone”). A total of 36 papers were identified as relevant to the purpose of our investigation. The studies reported the positive effects of the investigated phenolic compounds on bone metabolism and their potential application as adjuvant treatments for osteoporosis, bone tumours, and periodontitis. Furthermore, their use on the titanium surfaces of orthopaedic prostheses could represent a possible application to improve the osteogenic processes and osseointegration. According to the study findings, resveratrol, curcumin, and quercetin are reported to have a wide variety of beneficial effects as supplement therapies. The investigated phenolic compounds seem to positively mediate bone metabolism and osteoclast-related pathologies.
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VitaminDWiki - 6 studies in both categories VDR and Bone

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VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways

Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise, Butyrate   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators

VitaminDWiki - The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (17 studies), Breast Cancer (20 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (23 studies), Hypertension (8 studies), Infant (21 studies), Lupus (6 studies), Metabolic Syndrome (3 studies), Mortality (4 studies), Multiple Sclerosis (11 studies), Obesity (15 studies), Pregnancy (23 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (32 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

VitaminDWiki pages with Vitamin D Receptor or VDR in title (400 as of Oct 2022)

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Items found: 411
Title Modified
Dengue viral production decreased 1000X if activate Vitamin D Receptor (in lab) – July 2020 04 Jul, 2020
4X less of one chemo needed after vitamin D receptor activation - June 2020 02 Jun, 2020
Dengue virus 2X to 4X more likely if vitamin D receptor gene problems 08 May, 2020
Colorectal Cancer Patients 2.4 X more likely to have poor Vitamin D receptors (less D to cells) – April 2020 02 May, 2020
Crohn’s Disease is associated with poor Vitamin D Receptor (many solutions) – April 2020 29 Apr, 2020
3X reduction in Chemotherapy dose by Photodynamic Priming of Vitamin D Receptor (mice) – March 2020 30 Mar, 2020
Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018 10 Mar, 2020
Multiple Sclerosis 2X-3X more likely if poor Vitamin D Receptor – Meta-analysis Feb 2020 26 Feb, 2020
Diabetes decreased by activating Vitamin D Receptor (transgenic mice) – Feb 2020 22 Feb, 2020
Large weight loss 32X more likely to be achieved if weight gain was due to Vitamin D Receptor – Jan 2020 31 Jan, 2020
Preterm birth associated with many genes, including the Vitamin D Receptor again – Jan 2020 30 Jan, 2020
Parkinson’s disease 1.6X more likely if a poor Vitamin D Receptor – meta-analysis Jan 2020 28 Jan, 2020
Colorectal cancer linked to poor Vitamin D Receptor (yet again) – Jan 2020 22 Jan, 2020
Strong interactions between Vitamin D and the gut microbiota via Butyrate and VDR – Dec 2019 08 Jan, 2020
Autism 2X more likely if poor Vitamin D Receptor (yet again) – meta-analysis Jan 2020 05 Jan, 2020
Autism 2X more likely with Vitamin D Receptor problems – many studies 05 Jan, 2020
Preterm birth 8X more likely if poor Vitamin D Receptor – Dec 2019 31 Dec, 2019
Risk of Multiple Sclerosis varies with the Vitamin D Receptor – meta-analysis Dec 2019 26 Dec, 2019
Depression associated with poor Vitamin D Receptor (in mice) – Dec 2019 24 Dec, 2019
1.8 X more likely to have additional Dental Implant Failure if poor Vitamin D Receptor – Dec 2019 18 Dec, 2019
Autoimmune disease treated by Vitamin D, Zinc (and other activators of Vitamin D Receptor) – Oct 2019 17 Dec, 2019
Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019 14 Dec, 2019
Hypertension risk increased 2.1 X if poor Vitamin D Receptor – Dec 2019 13 Dec, 2019
Obesity 2X higher risk if a poor Vitamin D Receptor (13th study) – Dec 2019 09 Dec, 2019
Parkinson’s disease 20 percent more likely in Asians if poor Vitamin D Receptor – meta-analysis April 2019 22 Nov, 2019
Vitamin D and Myopia, AMD, Diabetic Retinopathy, Uveitis, Glaucoma, VDR etc. – May 2015 18 Nov, 2019
Vitamin D Receptor in gut can be activated by lithocholic acid produced by gut bacteria 16 Nov, 2019
Microbiomes of both gut and airway are affected by Vitamin D and Vitamin D Receptor – Nov 2018 16 Nov, 2019
Resveratrol improves health (Vitamin D receptor, etc.) 16 Nov, 2019
Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019 15 Nov, 2019
Preterm birth 9 X more likely if fetus had a poor Vitamin D Receptor and previous miscarriage – Aug 2017 12 Nov, 2019
Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015 12 Nov, 2019
Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016 09 Nov, 2019
Cancer is leading cause of death - Vitamin D and Receptor activators help 09 Nov, 2019
Asthma 3.7X higher risk of poor Vitamin D Receptor (teens in Taiwan in this case) – Nov 2019 07 Nov, 2019
Melanoma cancer growth slowed by increased Vitamin D Receptor (yet again) – Oct 2019 06 Nov, 2019
Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019 05 Nov, 2019
Increased risk of Osteoporosis if poor Vitamin D Receptor (UK males this time) – Sept 2019 01 Nov, 2019
Multiple Sclerosis much more likely if poor Vitamin D Receptor – several studies 31 Oct, 2019
Vitamin D Receptor summary 30 Oct, 2019
Liver Cirrhosis death is 4X more likely if poor Vitamin D Receptor – Sept 2018 29 Oct, 2019
Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019 23 Oct, 2019
Temporary hair loss (Telogen Effluvium) is 15X more likely if poor Vitamin D Receptor – Oct 2019 22 Oct, 2019
Melatonin appears to also use the Vitamin D Receptor – Oct 2019 22 Oct, 2019
Breast cancer associated with Vitamin D Receptor (14th study) – Oct 2019 19 Oct, 2019
Hand, foot, and Mouth disease is 14X more likely if poor Vitamin D Receptor – Oct 2019 06 Oct, 2019
Lupus associated with both low vitamin D and Vitamin D receptor problems – April 2016 05 Oct, 2019
Non-alcoholic fatty liver disease and the Vitamin D Receptor – editorial Sept 2019 29 Sep, 2019
Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019 17 Sep, 2019
Leprosy risk is reduced by 3X for some types of Vitamin D Receptor (Brazil) – Sept 2019 13 Sep, 2019
Metabolic Syndrome 11X more likely if have a poor Vitamin D Receptor – 2018 10 Sep, 2019
Osteoporosis 3X higher risk of in white men having a poor Vitamin D receptor – Aug 2019 27 Aug, 2019
Obesity associated with poor Vitamin D genes (VDR in this study) – Jan 2018 24 Aug, 2019
Osteoporosis is associated with genes such as the Vitamin D Receptor – July 2019 22 Aug, 2019
Lyme disease appears to massively deactivate the Vitamin D Receptor - 2019 14 Aug, 2019
Hypertension, Vitamin D, and Vitamin D Receptor – Aug 2019 08 Aug, 2019
Autoimmunity problems often associated with poor Vitamin D Receptors – March 2019 31 Jul, 2019
Septic children have low Vitamin D (54 studies, ignored Vitamin D Receptor) – meta-analysis April 2019 31 Jul, 2019
Breast Cancer death 1.8 X more likely if poor Vitamin D Receptor – April 2019 29 Jul, 2019
Breast Cancer death 1.8 X more likely if poor vitamin D Receptor – July 2019 29 Jul, 2019
Vitamin D Receptor, the gut, the immune system, and the Middle East – May 2019 14 Jul, 2019
Vitamin D Receptor - activation and deactivation- self-hacked June 2019 14 Jul, 2019
MRSA Carriers not helped by 4,000 IU of Vitamin D (probably poor Vitamin D Receptor) – RCT Sept 2018 14 Jul, 2019
Graves' disease 1.4 X more likely if poor Vitamin D Receptor – March 2019 12 Jul, 2019
TB patients had low Vitamin D and poor Vitamin D receptor – June 2019 01 Jul, 2019
Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019 24 Jun, 2019
Lumbar disc degeneration 30 percent more likely if poor Vitamin D Receptor – May 2019 20 Jun, 2019
Tuberculosis increased risk if poor Vitamin D receptor varies by race – meta-analysis Feb 2019 20 Jun, 2019
Vitamin D Receptor synonyms 14 Jun, 2019
Blood cell cancer is associated with a 3X worse Vitamin D Receptor – June 2019 14 Jun, 2019
Vitamin D Receptor described at US National Library of Medicine 13 Jun, 2019
Inflammatory bowel disease, gut bionome and Vitamin D Receptor – 2018 13 Jun, 2019
Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019 13 Jun, 2019
TB and Leprosy are easily confused and associated with Vitamin D Receptor 10 Jun, 2019
Best supplements for hay fever (Quercetin, which activates the Vitamin D receptor) - June 2019 05 Jun, 2019
After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019 04 Jun, 2019
Tuberculosis association with Vitamin D Receptor varies a lot with race – meta-analysis May 2019 30 May, 2019
Multiple Sclerosis and Vitamin D Receptor super enhancers – March 2019 23 May, 2019
Lupus in children 2.6 X more likely if they had poor Vitamin D Receptor – Jan 2017 20 May, 2019
Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019 18 May, 2019
Curcumin may increase Vitamin D in tissues (activates Vitamin D Receptor) – Dec 2010 04 May, 2019
Hodgkin’s lymphoma and Vitamin D Receptor - June 2012 29 Apr, 2019
Resveratrol prevented bone loss associated with T2DM (probably via VDR) – RCT Sept 2018 29 Apr, 2019
Arthritis runs in Pakistani families (Vitamin D Receptor) – March 2019 24 Apr, 2019
Hypertension, Vitamin D Receptor, and FokI gene – Editorial Aug 2014 23 Apr, 2019
Preeclampsia 2X more likely if poor Vitamin D Receptor – April 2019 23 Apr, 2019
Certain types of Tuberculosis are 2X more likely with a poor Vitamin D Receptor – April 2019 20 Apr, 2019
Skin fold thickness but not BMI associated with poor Vitamin D Receptor in Han Chinese – April 2018 13 Apr, 2019
Good Vitamin D receptor reduced bladder cancer and cisplatin deaths – April 2019 11 Apr, 2019
Ulcerative Colitis – half have poor level of Vitamin D Receptor vs only one in ten normally – June 2017 01 Apr, 2019
A poor Vitamin D Receptor is associated with many cancers (oral cancer in this case) – Jan 2019 26 Mar, 2019
Alzheimer’s (1.2X) and Parkenson’s (1.3X) more likely if poor Vitamin D Receptor – meta-analysis March 2019 23 Mar, 2019
Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019 23 Mar, 2019
Diabetic nephropathy deactivates the Vitamin D Receptor, reducing tissue Vit D – Feb 2019 01 Mar, 2019
Vitamin D and Ageing (29 page chapter, VDR decreases with age) – Feb 2019 23 Feb, 2019
Many autoimmune diseases associated with latitude and vitamin D receptor – March 2016 22 Feb, 2019
Upper respiratory infection associated with poor Vitamin D Receptor – Oct 2018 16 Feb, 2019
Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019 15 Feb, 2019
Women with Breast Cancer were 16.9 times more likely to have a poor Vitamin D Receptor – Jan 2019 11 Feb, 2019
Progesterone activates vitamin D receptor - many studies 05 Feb, 2019
Created by admin. Last Modification: Monday October 3, 2022 16:22:58 GMT-0000 by admin. (Version 7)
Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022        
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