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Vitamin D intervention (amount not stated in abstract) helped pregnancy – RCT Feb 2015

Supplementation of Vitamin D in pregnancy and its correlation with feto-maternal outcome

Clinical Endocrinology, DOI: 10.1111/cen.12751
Aanchal Sablok1,*, Aruna Batra1, Karishma Thariani1, Achla Batra1, Rekha Bharti1, Abha Rani Aggarwal2, B C Kabi3 andHarish Chellani4
1Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
2National Institute of Medical Statistics, All India Institute of Medical Sciences, New Delhi, India
3Department of Biochemistry, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
4Department of Paediatrics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
* Corresponding author: Dr Aanchal Sablok, Senior Resident,
Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi. 110029, India. Email: aanchalsablok54 at gmail.com

VitaminDWiki Summary
Vitamin D Level 18 ng 32 ng
Preterm labor
or Pre-eclampsia
or Gestational Diabetes
44 % 20 %
Birth weight 2.4 kg2.6 kg

Context: Vitamin D deficiency widely prevalent throughout the world. Pregnant women, neonates and infants form most vulnerable groups for vitamin D deficiency.

Objective: 1) To find prevalence of vitamin D deficiency in pregnant women. 2) To evaluate effect of supplementation with cholecalciferol in improving vitamin D levels in pregnant women and evaluate its correlation with feto-maternal outcome.

Design: Randomized control trial from years 2010-2012.

Setting: Tertiary care centre, Delhi, India.

Participants: 180 pregnant women. Study population divided randomly into 2 groups; Group A: non-intervention (60 women) and Group B: intervention (120 women).

Intervention: The intervention group received supplementation of vitamin D in dosages depending upon 25(OH)-D levels.

Main Outcome measures: Risk of maternal complications like Pre-term labour; pre-eclampsia and gestational diabetes associated with Vitamin D deficiency and risk of Low birth weight and poor APGAR score in infants of mothers with Vitamin D deficiency.

Results: Adjusted serum 25(OH)-D concentration was lower in group A as compared to group B (mean 46.11 ± 74.21 nmol/L vs 80 ± 51.53 nmol/L). 44% patients in group A and 20.3% patients in group B developed Pre-term labour/Pre-eclampsia/Gestational Diabetes. New-borns of mothers in group A had lower cord blood levels of 25(OH)-D levels as compared to group B (mean 43.11 ± 81.32 nmol/L vs 56.8 ± 47.52 nmol/L). They also had lower birth weight of mean 2.4 ± 0.38 kg as compared to group B 2.6 ± 0.33 kg.

Conclusions: Vitamin D supplementation reduces risk of maternal comorbidities and helps improve neonatal outcomes.

See also VitaminDWiki

Healthy pregnancies need lots of vitamin D has the following summary

0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRandomized Controlled Trial
3. Gestational Diabetes 3 times Randomized Controlled Trial
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times Randomized Controlled Trial
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times Randomized Controlled Trial
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
Randomized Controlled Trial
10. Childhood Wheezing 1.3 times Randomized Controlled Trial
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRandomized Controlled Trial
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times Randomized Controlled Trial
16. Childhood Respiratory Tract visits 2.5 times Randomized Controlled Trial

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