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Very low birth weight infants were OK with 600 IU of vitamin D plus Calcium and Phosphorus – May 2018

Functional indicators of vitamin D adequacy for very low birth weight infants

Journal of Perinatology (2018), doi:10.1038/s41372-018-0098-7
Sarah N. Taylor, Amy Wahlquist, Carol L. Wagner, Viswanathan Ramakrishnan,
Myla Ebeling & Bruce W. Hollis


Most studies have found that more than 600 IU is needed, even for normal births
Various studies also adjust the dose with infant weight

Infant-Child category starts with

Having a good level of vitamin D cuts in half the amount of:

Need even more IUs of vitamin D to get a good level if;

  • Have little vitamin D: premie, twin, mother did not get much sun access
  • Get little vitamin D: dark skin, little access to sun
  • Vitamin D is consumed faster than normal due to sickness
  • Older (need at least 100 IU/kilogram, far more if obese)
  • Not get any vitamin D from formula (breast fed) or (fortified) milk
    Note – formula does not even provide 400 IU of vitamin D daily

Infants-Children need Vitamin D

  • Sun is great – well known for 1,000’s of years.
    US govt (1934) even said infants should be out in the sun
  • One country recommended 2,000 IU daily for decades – with no known problems
  • As with adults, infants and children can have loading doses and rarely need tests
  • Daily dose appears to be best, but monthly seems OK
  • Vitamin D is typically given to infants in the form of drops
       big difference in taste between brands
       can also use water-soluable form of vitamin D in milk, food, juice,
  • Infants have evolved to get a big boost of vitamin D immediately after birth
    Colostrum has 3X more vitamin D than breast milk - provided the mother has any vitamin D to spare
  • 100 IU per kg of infant July 2011, Poland etc.
    1000 IU per 25 lbs.jpg
    More than 100 IU/kg is probably better

Getting Vitamin D into infants
Many infants reject vitamin D drops, even when put on nipple
I speculate that the rejection is due to one or more of: additives, taste, and oils.
Infants have a hard time digesting oils, 1999  1997   and palm oils W.A. Price 1 2 3
Coconut oil, such as in D-Drops, is digested by infants. 1,   2   3
Bio-Tech Pharmacal Vitamin D has NO additves, taste, nor oil
One capsule of 50,000 Bio-Tech Pharmacal Vitamin D could be stirred into monthly formula or given once a month
   this would result in ~1,600 IUs per day for infant, and higher dose with weight/age/formula consumption

Free PDF is online at Sci-Hub

Objective: To identify the vitamin D status to optimize calcium and bone health in preterm infants.

Study design
Very low birth weight infants had measurement of 25-hydroxyvitamin D status and markers of calcium and bone health from birth to term age. Piecewise linear regression modeling was performed to identify a 25-hydroxyvitamin D threshold associated with stable parathyroid hormone concentration and bone mineralization.

In a cohort of 89 infants at term age, femur BMC and density increased linearly with 25-hydroxyvitamin D status until reaching a threshold of 48 ng/mL and 46 ng/mL, respectively. Parathyroid hormone status decreased as vitamin D status increased until reaching a plateau at 25-hydroxyvitamin D of 42 ng/mL.

Preterm infant vitamin D status was significantly associated with PTH status and femur mineralization with suggestion that achieving a specific 25-hydroxyvitamin concentration is associated with optimal calcium homeostasis and femur bone mineralization.

From the PDF
The median (interquartile range) intake through the study were

  • vitamin D 609 (519,678) IU/day,
  • calcium 182 (141, 244) mg/kg/day
  • phosphorus 122 (85, 165) mg/kg/day

Created by admin. Last Modification: Tuesday May 15, 2018 16:01:07 GMT-0000 by admin. (Version 5)
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