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Very low birth weight infants were OK with 600 IU of vitamin D plus Calcium and Phosphorus – May 2018

Functional indicators of vitamin D adequacy for very low birth weight infants

Journal of Perinatology (2018), doi:10.1038/s41372-018-0098-7
Sarah N. Taylor, Amy Wahlquist, Carol L. Wagner, Viswanathan Ramakrishnan,
Myla Ebeling & Bruce W. Hollis

VitaminDWiki

Most studies have found that more than 600 IU is needed, even for normal births
Various studies also adjust the dose with infant weight

Infant-Child category starts with

Having a good level of vitamin D cuts in half the amount of:

Need even more IUs of vitamin D to get a good level if;

  • Have little vitamin D: premie, twin, mother did not get much sun access
  • Get little vitamin D: dark skin, little access to sun
  • Vitamin D is consumed faster than normal due to sickness
  • Older (need at least 100 IU/kilogram, far more if obese)
  • Not get any vitamin D from formula (breast fed) or (fortified) milk
    Note – formula does not even provide 400 IU of vitamin D daily

Infants-Children need Vitamin D


Free PDF is online at Sci-Hub

Objective: To identify the vitamin D status to optimize calcium and bone health in preterm infants.

Study design
Very low birth weight infants had measurement of 25-hydroxyvitamin D status and markers of calcium and bone health from birth to term age. Piecewise linear regression modeling was performed to identify a 25-hydroxyvitamin D threshold associated with stable parathyroid hormone concentration and bone mineralization.

Results
In a cohort of 89 infants at term age, femur BMC and density increased linearly with 25-hydroxyvitamin D status until reaching a threshold of 48 ng/mL and 46 ng/mL, respectively. Parathyroid hormone status decreased as vitamin D status increased until reaching a plateau at 25-hydroxyvitamin D of 42 ng/mL.

Conclusion
Preterm infant vitamin D status was significantly associated with PTH status and femur mineralization with suggestion that achieving a specific 25-hydroxyvitamin concentration is associated with optimal calcium homeostasis and femur bone mineralization.

From the PDF
The median (interquartile range) intake through the study were

  • vitamin D 609 (519,678) IU/day,
  • calcium 182 (141, 244) mg/kg/day
  • phosphorus 122 (85, 165) mg/kg/day


Created by admin. Last Modification: Tuesday May 15, 2018 16:01:07 GMT-0000 by admin. (Version 5)