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Treating Vitamin D deficiency in senior women – such as 50,000 IU daily for 15 days then twice a month – Review April 2019

Therapeutic regimens for vitamin D deficiency in postmenopausal women: a systematic review.

Prz Menopauzalny. 2019 Apr;18(1):57-62. doi: 10.5114/pm.2019.84159.
Tayem Y1, Alotaibi R2, Hozayen R2, Hassan A3.

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It is likely that loading doses need only last for 10 days, rather than 15

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Hansen KE, Johnson RE, Chambers KR, et al. Treatment of vitamin D insufficiency in postmenopausal women: a randomized clinical trial. JAMA Intern Med 2015; 175: 1612-1621.
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INTRODUCTION: We reviewed the most effective vitamin D3 regimen for vitamin D deficiency in postmenopausal women.

MATERIAL AND METHODS:
We searched for studies and clinical trials conducted on healthy postmenopausal women published on PubMed from 2000 to 2018 using the term "Vitamin D deficiency" combined with the following terms: "dose", "supplement", "supplementation", "cholecalciferol" or "cholecalciferol dose". We identified 1376 articles which matched the search criteria. Based on reviewing the title and abstract, 17 articles were eligible for a full-text review. Of those, 12 manuscripts were ultimately included.

RESULTS:
A majority of the studies (75%) reported using daily maintenance doses which were predominantly administered orally (83.3%). Two studies reported favorable results following therapy with a single oral dose of 300,000 IU. After one month, however, 25-hydroxy vitamin D [25(OH)D] was satisfactory; both studies failed to maintain adequate responses after 60 and 90 days. One study found that loading oral doses of 50,000 IU/day for 2 weeks followed by the same doses every 2 weeks for one year were effective. Five studies employed oral doses of 800 IU/day but none of them reported that this dose was adequate. Three studies used doses of 1000 IU/day but only two of them reported positive results. Three trials examined oral doses of 2000 IU/day and another 3 studies tested oral doses of 4000-4800 IU/day. All of them reported acceptable responses that lasted with continued treatment.

CONCLUSIONS:
Oral maintenance doses of 2000-4800 IU/day satisfactorily corrected vitamin D deficiency and maintained 25(OH)D levels in postmenopausal women with continuous therapy.

Created by admin. Last Modification: Friday June 14, 2019 02:51:58 GMT-0000 by admin. (Version 9)

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12126 50,000 RCT.jpg admin 14 Jun, 2019 02:45 58.09 Kb 196
12125 50,000 RCT.pdf admin 14 Jun, 2019 02:45 592.89 Kb 45
12124 50,000.jpg admin 14 Jun, 2019 02:24 100.48 Kb 304
12123 Therapeutic regimens 2019.pdf PDF 2019 admin 14 Jun, 2019 02:20 73.08 Kb 51
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