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Treating Vitamin D deficiency in senior women – such as 50,000 IU daily for 15 days then twice a month – Review April 2019

Therapeutic regimens for vitamin D deficiency in postmenopausal women: a systematic review.

Prz Menopauzalny. 2019 Apr;18(1):57-62. doi: 10.5114/pm.2019.84159.
Tayem Y1, Alotaibi R2, Hozayen R2, Hassan A3.

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It is likely that loading doses need only last for 10 days, rather than 15

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Treatment of vitamin D insufficiency in postmenopausal women: a randomized clinical trial.

JAMA Intern Med 2015; 175: 1612-1621.
Hansen KE, Johnson RE, Chambers KR, et al.
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INTRODUCTION: We reviewed the most effective vitamin D3 regimen for vitamin D deficiency in postmenopausal women.

MATERIAL AND METHODS:
We searched for studies and clinical trials conducted on healthy postmenopausal women published on PubMed from 2000 to 2018 using the term "Vitamin D deficiency" combined with the following terms: "dose", "supplement", "supplementation", "cholecalciferol" or "cholecalciferol dose". We identified 1376 articles which matched the search criteria. Based on reviewing the title and abstract, 17 articles were eligible for a full-text review. Of those, 12 manuscripts were ultimately included.

RESULTS:
A majority of the studies (75%) reported using daily maintenance doses which were predominantly administered orally (83.3%). Two studies reported favorable results following therapy with a single oral dose of 300,000 IU. After one month, however, 25-hydroxy vitamin D [25(OH)D] was satisfactory; both studies failed to maintain adequate responses after 60 and 90 days. One study found that loading oral doses of 50,000 IU/day for 2 weeks followed by the same doses every 2 weeks for one year were effective. Five studies employed oral doses of 800 IU/day but none of them reported that this dose was adequate. Three studies used doses of 1000 IU/day but only two of them reported positive results. Three trials examined oral doses of 2000 IU/day and another 3 studies tested oral doses of 4000-4800 IU/day. All of them reported acceptable responses that lasted with continued treatment.

CONCLUSIONS:
Oral maintenance doses of 2000-4800 IU/day satisfactorily corrected vitamin D deficiency and maintained 25(OH)D levels in postmenopausal women with continuous therapy.


Created by admin. Last Modification: Sunday June 7, 2020 02:22:22 GMT-0000 by admin. (Version 12)

Attached files

ID Name Comment Uploaded Size Downloads
13887 50,000 RCT suspected.jpg admin 07 Jun, 2020 68.21 Kb 1201
12125 50,000 RCT.pdf admin 14 Jun, 2019 592.89 Kb 646
12124 50,000.jpg admin 14 Jun, 2019 100.48 Kb 8990
12123 Therapeutic regimens 2019.pdf admin 14 Jun, 2019 73.08 Kb 658