Thyroid Cancer 1.4 X higher risk if low vitamin D– meta-analysis Feb 2018

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Association between vitamin D deficiency and risk of thyroid cancer: a case-control study and a meta-analysis.

J Endocrinol Invest. 2018 Feb 20. doi:10.1007/s40618-018-0853-9
Hu MJ1, Zhang Q1, Liang L1, Wang SY2, Zheng XC2, Zhou MM1, Yang YW1, Zhong Q1, Huang F3.

PURPOSE: Although vitamin D is reportedly associated with various cancers, the association between vitamin D and thyroid cancer is indefinite. We aimed to investigate whether this association applies to thyroid cancer (TC).

METHODS:
A total of 276 Chinese Han people were recruited in a current matched case-control study. Multivariable conditional logistic regression was computed to estimate the association between plasma 25(OH)D and papillary thyroid cancer (PTC). In addition, we searched relevant studies in PubMed and Web of Science databases before December 2017 to conduct a meta-analysis.

RESULTS:
In our case-control study, plasma 25(OH)D concentration was inversely associated with PTC risk (highest tertile vs lowest tertile: adjusted OR = 0.25; 95% CI 0.10, 0.61; Ptrend = 0.003). This association was independent of body mass index and physical activity (all adjusted Pinteraction > 0.05).
A total of 11 studies were included in the meta-analysis, among which ten studies have been published and one was our case-control study. Compared with 25(OH)D non-deficient group, the pooled OR of TC was 1.42 (95% CI 1.17, 1.73) in the deficient group. Similarly, blood 25(OH)D levels in patients with TC were tend to be lower than those in the controls (SMD = - 0.20, 95% CI - 0.36, - 0.03).

CONCLUSIONS: A high level of circulating 25(OH)D was associated with a decreased TC risk. This association has important significance in public health and should, therefore, be further studied.

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Vitamin D-Related Genes and Thyroid Cancer—A Systematic Review - Nov 2022 (no associations found)

Int. J. Mol. Sci. 2022, 23(21), 13661; https://doi.org/10.3390/ijms232113661
by Adam Maciejewski and Katarzyna Lacka
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, 60355 Poznan, Poland

Vitamin D, formerly known for its role in calcium-phosphorus homeostasis, was shown to exert a broad influence on immunity and on differentiation and proliferation processes in the last few years. In the field of endocrinology, there is proof of the potential role of vitamin D and vitamin D-related genes in the pathogenesis of thyroid cancer—the most prevalent endocrine malignancy. Therefore, the study aimed to systematically review the publications on the association between vitamin D-related gene variants (polymorphisms, mutations, etc.) and thyroid cancer. PubMed, EMBASE, Scopus, and Web of Science electronic databases were searched for relevant studies. A total of ten studies were found that met the inclusion criteria.
Six vitamin D-related genes were analyzed (

• VDR—vitamin D receptor,
• CYP2R1—cytochrome P450 family 2 subfamily R member 1,
• CYP24A1—cytochrome P450 family 24 subfamily A member 1,
• CYP27B1—cytochrome P450 family 27 subfamily B member 1,
• DHCR7—7-dehydrocholesterol reductase and
• CUBN—cubilin).

Moreover, a meta-analysis was conducted to summarize the data from the studies on VDR polymorphisms (rs2228570/FokI, rs1544410/BsmI, rs7975232/ApaI and rs731236/TaqI). Some associations between thyroid cancer risk (VDR, CYP24A1, DHCR7) or the clinical course of the disease (VDR) and vitamin D-related gene polymorphisms were described in the literature. However, these results seem inconclusive and need validation. A meta-analysis of the five studies of common VDR polymorphisms did not confirm their association with increased susceptibility to differentiated thyroid cancer. Further efforts are necessary to improve our understanding of thyroid cancer pathogenesis and implement targeted therapies for refractory cases
 Download the PDF from VitaminDWiki

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VitaminDWiki: Cancer- Other category with THYROID in title (7 as of Oct 2022)

This list is automatically updated

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VitaminDWiki - Cancer category (includes a VDR section)

• Cancer 260 items Overview Cancer and vitamin D
• Cancer and Vitamin D - many studies
• After Cancer Diagnosis 99 items
• Bladder Cancer 25 items
• Breast Cancer 245 items Overview Breast Cancer and Vitamin D
• Colon Cancer 136 items Overview Cancer-Colon and vitamin D
• Leukemia 18 items
• Liver Cancer 16 items
• Lung Cancer 53 items Overview Lung cancer and vitamin D
• Lymphoma Cancer 23 items
• Other Cancer 61 items
• Ovarian Cancer 24 items
• Pancreatic Cancer 54 items
• Prostate Cancer 97 items Overview Prostate Cancer and Vitamin D
• Skin Cancer 117 items Overview Suntan, melanoma and vitamin D
• Easiest way to treat cancer – take Vitamin D – Nov 2022
• 2X increase of 14 cancers in non-seniors in 20 years (low vitamin D) – Sept 2022
• Vitamin D prevents and treats cancer in many ways – May 2021
• Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
• Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
• Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
• 8 ways that Cancer might be prevented by Vitamin D - June 2019
• Cancer stem cells and Vitamin D - many studies
• Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
• Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
• Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
• Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
• Melanoma 25 X more likely if low vitamin D – Feb 2018
• Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018

Cancers get less Vitamin D when there is a poor Vitamin D Receptor

• Vitamin D Receptor pages in VitaminDWiki with CANCER in title 80 as of Nov 2022
• Cancer and the Vitamin D Receptor, a primer – Sept 2017
• Vitamin D Receptor and Cancer
• Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
• Cancer (general) and VDR 23 articles
• Breast Cancer and VDR 20 articles
• Colon Cancer and VDR 13 articles
• Prostate Cancer and VDR 7 articles
• Skin Cancer and VDR 10 articles
  • Note some Health problems, such as some Cancers, protect themselves
    by actively reducing Receptor activation