Table of contents
The Effects of Vitamin D Supplementation and 25-hydroxyvitamin D Levels on The Risk of MI and Mortality
Prakash Acharya M.D.*, Tarun Dalia M.D.*, Sagar Ranka M.D.*, Prince Sethi M.D.*, Olurinde A. Oni M.B.B.S., M.P.H.j, Maya S. Safarova M.D., PhD, * Deepak Parashara M.D. *tî, Kamal Gupta M.D. *, Rajat S. Barua M.D., Ph.D rajat.barua@va. gov|J
- Department of Cardiovascular Medicine, University of Kansas Medical Cente City, KS
Objective: Aim of the study was to examine the effects of the vitamin D (Vit-D) treatment and non-treatment on Vit-D-deficient patients without a prior history of myocardial infarction (MI).
Materials and Methods: This is an retrospective, observational, nested case-control study of patients (N=20,025) with low 25-hydroxyvitamin D [(25-OH)D] levels (<20 ng/ml) who received care at the Veterans Health Administration from 1999-2018. Patients were divided into three groups: Group A (untreated, levels <20 ng/ml), Group B (treated, levels 21-29 ng/ml), and Group C (treated, levels >30 ng/ml). The risk of MI and all-cause-mortality were compared utilizing propensity score-weighted cox-proportional hazard models.
Results. Among the cohort of 20,025 patients, the risk of MI was significantly lower in Group C, compared to Group B [hazard ratio (HR) 0.65, 95% CI; 0.49-0.85, P=.002] and Group A (HR 0.73, 95% CI; 0.55-0.96), P=.02). There was no difference in the risk of MI between Group B and Group A (HR 1.14, 95% CI; 0.91-1.42, P=.24]. Compared to Group A, both Group B (HR 0.59, 95% CI; 0.54-0.63, P<.001] and Group C (HR 0.61, 95% CI; 0.56-0.67, P<.001] had significantly lower all-cause-mortality. There was no difference in all-cause- mortality between Group B and Group C (HR 0.99, 95% CI; 0.89-1.09, P=.78).
Conclusions. In patients with Vit-D-deficiency and no prior history of MI, treatment to the (25-OH)D level of >20 ng/ml and >30 ng/ml was associated with a significantly lower risk of all-cause-mortality. The lower risk of MI was observed only in individuals maintaining the (25-OH)D levels >30 ng/ml.
 Download the PDF from VitaminDWiki
Description of the study at MedPage Today Interview of the lead author Video of study by Dr. Campbell Oct 2021
VitaminDWiki
- Heart Failure and Vitamin D meta-analyses - many studies
- Cardiovascular Disease is treated by Vitamin D - many studies
- Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021
During the 19 year study period it was thought that rasing vitamin D levels to 30 ng was enough
Suspect that >50 ng would be much better
- Is 50 ng of vitamin D too high, just right, or not enough
- All items in category Optimum Vitamin D
99 items Suspect Magnesium and/or Omega-3 would also reduce cardiovascular deaths even more
-
16 articles are in both Cardiovascular and Magnesium categories 34 articles are in both Cardiovascular and Omega-3 categories
Cardiovascular category
533 items In Cardiovascular category Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022
- Overview Cardiovascular and vitamin D
- Cardiovascular Disease is treated by Vitamin D - many studies 39+ meta-analyses
- Coronary Artery Disease and Vitamin D - many studies 18+
- Cardiovascular problems reduced by Omega-3 - many studies 34+
- Arteries and Atherosclerosis and Vitamin D - many studies 71+
- Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 26+
- Statins and Vitamin D - many studies 25+
- Arterial Stiffness and Vitamins – only Vitamin D was found to help – meta-analysis Feb 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021
- Sudden Cardiac Arrest – 2.8 X higher risk if low vitamin D – 2019
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022
Items in both categories Cardiovascular and Mortality
- 5X lower Cardiovascular death rate in regions consuming more fish and vegetables, (and lower obesity) – Dec 2023
- Sudden Cardiac Arrest 10.8 X more likely if severe vitamin D deficiency – May 2024
- Fewer deaths (All-cause, Cardiovascular, Cancer) when Vitamin D levels are above 36 ng – April 2024
- Risk of Cardiovascular death decreased 5X (lowest to highest Vitamin D level)- Feb 2024
- Low Vitamin D associated with CHD, stroke, death, etc, (Mendelian analhysis) - Dec 2021
- Death rates of Cardiovascular patients keep decreasing until 90 nmol of Vitamin D - May 2023
- Less likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022
- Metabolic Syndrome with low vitamin D increases CVD mortality by 1.7 X – July 2022
- 1.7 X less risk of Heart Failure death if previously had taken any amount of vitamin D - Jan 2022
- 1.7 X less risk of Heart Failure death if previously had taken any amount of vitamin D - Jan 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Omega-3 reduced cardiovascular deaths by 16 percent (427,678 people) – March 2020
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Mortality associated with Vitamin K insufficiency (PREVEND Study) – Nov 2017
- Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
- 7X increased chance of death if coronary artery disease and low vitamin D – Oct 2013
- Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013
- Vitamin D protects against many types of health problems – review May 2013
- Almost 6X more likely to die after coronary bypass if vitamin D deficient – Dec 2012
- Predicted cardiac surgery death associated with low vitamin D levels – Dec 2012
- 3 X increased chance of death if have asthma – study of 200,000 people over 10 years – Nov 2012
- Low levels of vitamin D associated with all cause mortality – Oct 2012
- Death in less than 2 years of Heart Failure associated with low vitamin D - April 2012
- Heart Failure early death 2X more likely if less than 20 nanograms of vitamin D – June 2012
- Chance of death after heart failure reduced by 1000 IU of vitamin D – Feb 2012
- Heart patients 10 percent more likely to die for every 4 ng less vitamin D – May 2011
- Did not find association between vitamin D and cardiovascular mortality – Sept 2010
- Table of outcomes for seniors vs vitamin D level
VA found less testing for vitamin D resulted in increased health costs – Jan 2012
Veterans and Vitamin D - many studies
Perhaps 4,000 dollars annual less health care costs if supplement with 5 dollars of Vitamin D
- Chart of VA hospital data of current study compared with German hospital data published in 2017
Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 20218509 visitors, last modified 06 Apr, 2023, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 16506 MI survival.jpg admin 28 Oct, 2021 63.00 Kb 533 16505 MI Vitamin D.pdf admin 28 Oct, 2021 1.10 Mb 285
-