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Stoss (bolus, loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT April 2021

Stoss therapy is safe for treatment of vitamin D deficiency in pediatric patients undergoing HSCT

Bone Marrow Transplant. 2021 Apr 19. doi: 10.1038/s41409-021-01294-x
Jessica Bodea 1, Kristen Beebe 2 3, Courtney Campbell 2, Dana Salzberg 2, Holly Miller 2, Roberta Adams 2 3, Lucia Mirea 2, Paul Castillo 4, Biljana Horn 4, Sandhya Bansal 5, Thalachallour Mohanakumar 5, Alexander Ngwube 6 7

Study used 100,000 to 600,000 IU


Vitamin D deficiency remains common among pediatric patients undergoing hematopoietic stem cell transplant (HSCT) despite both aggressive and standard of care strategies. This study examined the safety and efficacy of single high-dose oral vitamin D therapy (Stoss therapy) for treatment of vitamin D deficiency in HSCT recipients. Patients ages 1-21 years presenting for HSCT were randomized to receive either Stoss regimen plus weekly/daily supplementation or standard of care, per US Endocrine Society guidelines. Among the total 48 subjects, 22 (46%) were randomized to Stoss and 26 (54%) to control arms. Baseline 25-hydroxyvitamin D (25-OHD) levels were insufficient/deficient in total of 34 (71%) patients, without difference between treatment groups. The Stoss regimen was well tolerated and no toxicity was observed. At Day +30, mean 25-OHD levels were significantly higher (P = 0.04) with Stoss (42.3 ± 12 μg/l) compared to controls (35.6 ± 14.3 μg/l), and a higher proportion of Stoss patients had adequate vitamin D levels than controls (85% vs 65%). Stoss therapy is a safe and efficacious treatment option for vitamin D deficiency in children undergoing HSCT and may achieve sufficient levels more rapidly than standard of care.
This trial was registered at www.clinicaltrials.gov as NCT03176849.

Loading Dose of Vitamin D category has the following

173 items in category
see also Overview Loading of vitamin D   Overview Toxicity of vitamin D
Injection category listing has 60 items
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of adverse reactions
Many studies report on the benefits resulting from loading doses

The TOP articles in Loading Dose of Vitamin D are listed here:

Better than Daily has the following

Non-daily (Bolus) is virtually always better: -Reasons include:

  1. Better compliance
    • Fewer opportunities to forget
    • Fewer times to have to take a pill - for those who dislike it
  2. High concentration resulting from infrequent dosing gets past some gene and gut limitations
    • Note: Many studies have found non-daily to be better than daily
      I am unaware of a single study which has found daily to be better than non-daily - Founder of VitaminDWiki Dec 2019

Created by admin. Last Modification: Wednesday April 21, 2021 00:47:07 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
15474 Stoss response.jpg admin 21 Apr, 2021 00:27 27.15 Kb 129
15473 Stoss 100K to 600K.jpg admin 21 Apr, 2021 00:27 23.15 Kb 186
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