Loading...
 
Toggle Health Problems and D

Standard Omega-3 not get past BB barrier in seniors at high risk of Alzheimer’s – Patrick hypothesis Oct 2018

Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer's disease.

FASEB J. 2018 Oct 5:fj201801412R. doi: 10.1096/fj.201801412R.
Patrick RP University of California San Francisco Benioff, Children's Hospital Oakland Research Institute, Oakland, California, USA.

VitaminDWiki

Items in both categories Cognitive and Omega-3 are listed here:

Note: Some Omega-3 supplements are of the phospholipid form and so should get past the BBB

VitaminDWiki pages with PATRICK or FOUNDMYFITNESS in title

This list is automatcially updated

Items found: 20
Title Modified
The Science of Magnesium and Its Role in Aging and Disease - Patrick March 2024 20 Mar, 2024
Reduce ageing with Vitamin D, Omega-3, and Exercise (video) - Patrick March 2024 06 Mar, 2024
High Omega-3 index increases longevity, even among smokers - Patrick Jan 2024 17 Jan, 2024
The Longevity and Brain Benefits of Vigorous Exercise - Patrick video Dec 2023 05 Dec, 2023
Benefits of Omega-3s - video and transcript - Patrick - Nov 2023 29 Nov, 2023
The Dangers of Vitamin D Deficiency (and why you should supplement), Video and transcript, Patrick - Nov 2023 29 Nov, 2023
Longevity experts take Vitamin D, Omega-3, and Magnesium - Patrick video Sept 2023 10 Nov, 2023
How Vitamin D, Omega-3s, and Exercise May Increase Longevity - Patrick Nov 2023 10 Nov, 2023
Vitamin D overview by Rhonda Patrick – Oct 2022 07 Oct, 2022
COVID probably fought by Vitamin D, might need 50 ng - Dr. Patrick Nov 8, 2021 21 Jul, 2022
Omega-3 decreases heart disease and COVID: Harris and Patrick, video and transcript - Dec 2021 07 Dec, 2021
Long-haul, VAERS, Ivermectin, vaccines, etc. Drs. Seheult, Patrick: Video with table of contents - Sept 17, 2021 21 Sep, 2021
COVID-19 fought by Vitamin D or Heat - Drs Seheult and Patrick video - March 3, 2021 07 Mar, 2021
Resveratrol benefits health in many ways - Dr. Patrick Sept 2019 26 Sep, 2019
Standard Omega-3 not get past BB barrier in seniors at high risk of Alzheimer’s – Patrick hypothesis Oct 2018 25 Dec, 2018
Benefits of Micronutrients, fasting, saunas, intense exercise, cold showers – Patrick April 2018 21 Apr, 2018
Off topic – Outline of 2 hour health webinar by Dr. Patrick – Oct 2017 12 Oct, 2017
Infographic of Vitamin D - FoundMyFitness 13 Dec, 2016
Autism, Vitamin D, and serotonin - Patrick interview by Mercola Feb 2016 14 Feb, 2016
Micronutrients, methylation, epigenetics, longevity podcast by Rhonda Patrick and Tim Ferriss - June 2015 22 Jun, 2015

 Download the PDF from VitaminDWiki

Dietary and supplemental intake of the ω-3 fatty acid docosahexaenoic acid (DHA) reduces risk of Alzheimer's disease (AD) and ameliorates symptoms. The apolipoprotein E ( APOE) 4 allele is the strongest risk factor for sporadic AD, exclusive of age.
APOE4 carriers respond well to the DHA present in fish but do not respond as well to dietary supplements.
The mechanisms behind this varied response remain unknown. I posit that the difference is that fish contain DHA in phospholipid form, whereas fish oil supplements do not. This influences whether DHA is metabolized to nonesterified DHA (free DHA) or a phospholipid form called lysophosphatidylcholine DHA (DHA-lysoPC). Free DHA is transported across the outer membrane leaflet of the blood-brain barrier (BBB) via passive diffusion, and DHA-lysoPC is transported across the inner membrane leaflet of the BBB via the major facilitator superfamily domain-containing protein 2A.
I propose that APOE4 carriers have impaired brain transport of free DHA but not of DHA-lysoPC, as a consequence of a breakdown in the outer membrane leaflet of the BBB, putting them at increased risk for AD. Dietary sources of DHA in phospholipid form may provide a means to increase plasma levels of DHA-lysoPC, thereby decreasing the risk of AD


Created by admin. Last Modification: Saturday February 5, 2022 17:44:33 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
11085 Alz, Omega-3 Patrick.pdf admin 25 Dec, 2018 2.35 Mb 771