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Small amounts of Vitamin D reduce Influenza risk by 22 percent (loading dose is far better) – meta-analysis Jan 2022

Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials

Front. Nutr., 07 January 2022 | https://doi.org/10.3389/fnut.2021.799709
Zhixin Zhu, Xiaoxia Zhu, Lanfang Gu, Yancen Zhan, Liang Chen and Xiuyang Li*
Department of Epidemiology and Biostatistics, Center for Clinical Big Data and Statistics, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

Background: Vitamin D supplementation improves the immune function of human body and can be a convenient way to prevent influenza. However, evidence on the protective effect of vitamin D supplementation on influenza from Randomized Controlled Trials (RCTs) is inconclusive.

Methods: RCTs regarding the association between vitamin D supplementation and influenza were identified by searching PubMed, Cochrane library, Embase and Chinese Biomedical Database (CBM) from inception until present (last updated on 10 November 2021). Studies that reported dosages and durations of vitamin D supplementation and number of influenza infections could be included. Heterogeneity was assessed using Cochran's Q test and I2 statistics, the meta-analysis was conducted by using a random-effects model, the pooled effects were expressed with risk ratio (RR) with 95% confidence interval (95% CI).

Results: 10 trials including 4859 individuals were ultimately eligible after scanning. There was no evidence of a significant heterogeneity among studies (I2 = 27%, P = 0.150). Meta-regression analysis finding indicated that country, latitude, average age, economic level, follow-up period and average daily vitamin D intake did not cause the statistical heterogeneity. The study finding indicates that substitution with vitamin D significantly reduces the risk of influenza infections (RR = 0.78, 95% CI:0.64–0.95). No evidence of publication bias was observed. Omission of any single trial had little impact on the pooled risk estimates.

Conclusions: The meta-analysis produced a corroboration that vitamin D supplement has a preventive effect on influenza. Strategies for preventing influenza can be optimized by vitamin D supplementation.
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VitaminDWiki - Flu update 2018 has

Vitamin D fights all phases of Influenza

VitaminDWiki - Overview Influenza and vitamin D

VitaminDWiki - Influenza prevented by 40 ng levels or treated with vitamin D hammer (50,000 IU) – June 2015

which has

VitaminDWiki - Loading Dose of Vitamin D category has

191 items in category
see also Overview Loading of vitamin D   Overview Toxicity of vitamin D
Better than Daily 1: Fewer chances to forget, 2) Gets past receptor barrier
Injection category has 61 items
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of serious adverse reactions
Many studies report on the benefits resulting from loading doses

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Created by admin. Last Modification: Tuesday January 25, 2022 14:29:06 GMT-0000 by admin. (Version 3)

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16921 Vitamin D and Influenza - Meta-Analysis.pdf PDF 2022 admin 25 Jan, 2022 02:49 1.96 Mb 74