Prenatal vitamin D supplementation and child respiratory health: A systematic review and meta-analysis of randomized controlled trials
World Allergy Organ J. 2020 Dec; 13(12) Nov 21. doi: 10.1016/j.waojou.2020.100486
Amare Abera Tareke,a,∗ Addis Alem Hadgu,b Andualem Mossie Ayana,a and Taddese Alemu Zerfuc,d
Items in both categories Pregnancy and Breathing are listed here:
- Small vitamin D doses given during pregnancy do not reduce childhood asthma – meta-analysis Dec 2020
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
- Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019
- Childhood Asthma risk greatly reduced if mothers were given 4,400 IU Vitamin D daily – RCT 2019
- Asthma 7 percent less likely for every 40 IU increase in (early) maternal diet – Feb 2018
- Pregnant women with low vitamin D (e.g. asthmatics) were more likely to have infants with vitamin D problems (asthmatics) – Jan 2018
- Lots of sugar while pregnant doubles asthma risk – 2017
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Reduction of infant asthma may require good vitamin D when lung development starts (4 weeks) – March 2017
- Birth asphyxia 2.4 times more likely if mother was vitamin D deficient – 2016
- Asthma reduced 31 percent when Omega-3 taken during pregnancy – RCT Dec 2016
- Vitamin D during pregnancy reduces risk of childhood asthma by 13 percent – meta-analysis Dec 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Asthmatic pregnant women had 30 percent more preterm births if air pollution (vitamin D not mentioned) – March 2016
- Asthma in 3 year olds decreased somewhat with 4,000 IU during pregnancy – RCT Jan 2016
- Asthma trial underway - 4,000 IU during pregnancy - March 2014
- Infant wheezing 40 percent less likely if mother supplemented with vitamin D, vitamin E, or Zinc – meta-analysis Aug 2015
- Respiratory distress after preterm birth is more likely if low vitamin D – review April 2015
- Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015
- Newborn acute lower respiratory tract infection associated with low maternal vitamin D – March 2015
- Low vitamin D during pregnancy associated with four health problems in children – Jan 2015
- Just 700 IU of vitamin D during pregnancy reduced rate of asthma at age 7 by 26 percent – Oct 2013
- Single dose of 200,000 IU of vitamin D during pregnancy did not reduce wheezing 3 years later – June 2013
- Season of birth associated with pneumonia (10 pcnt) and multiple sclerosis (30 pcnt) – May 2013
- Dial D for danger – absurd editorial in Thorax – Oct 2012
- High maternal vitamin D resulted in 30 percent less infant problems with breathing – Nov 2011
- Smoking while pregnant lowers vitamin D and increases child asthma by 3.6 X – Aug 2011
- 800 IU Vitamin D while pregnant decrease child asthma by 2X- Sept 2010
- Vitamin D Newsletter May 2010
- Winter babies are more prone to food allergies
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Systematic review and meta-analyses of observational studies on maternal vitamin D status and risk of respiratory allergic conditions indicated that mothers who had supplementation during pregnancy could decrease the risk of recurrent wheeze or asthma in their offspring.
We conducted this meta-analysis of Randomized Controlled Trials with the primary intention of detecting the effect of prenatal vitamin D supplementation on the offspring's asthma. Secondary outcomes under respiratory health include eczema, lower respiratory tract infections, Immunoglobulin E positive test, upper respiratory tract infections, and allergic rhinitis.
A comprehensive search of PubMed, ScienceDirect, Google Scholar, and Cochrane Library databases was performed to retrieve randomized controlled trials. Risk Ratio with 95% confidence intervals was computed from dichotomous data using a random-effects model, with I2 >50% representing notable heterogeneity.
Six clinical trials met the inclusion criteria, involving a total of 2898 subjects (1461 experimental group and 1437 control group). There was non-significant inverse relationship between vitamin D intake during pregnancy and the occurrence of asthma in offspring (pooled RR = 0.89, 95% CI = 0.69–1.15, I2 = 46% and Z-static = 0.90, P-value = 0.37). There is no significant difference in the risk of assessed childhood respiratory problems due to maternal supplementation of vitamin D during pregnancy.
Conclusion and implications
Currently, there is no fertile evidence to promote vitamin D supplementation in pregnancy for childhood respiratory health. Future clinical trials should emphasize early initiation of vitamin D supplementation, consider 6 weeks to 6 months postnatal critical window for vitamin D deficiency for offspring, lower risk dose of vitamin D, and identify different phenotypes of asthma and response to vitamin D supplementation.