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Sleep Apnea and Vitamin D - many studies


13+ VitaminDWiki pages have SLEEP APNEA in the title

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Items found: 14


13.8 X increased risk of Pediatric Obstructive Sleep Apnea if vitamin D deficient – Oct 2024

Vitamin D Deficiency and Pediatric Obstructive Sleep Apnea Severity
AJAMA Otolaryngol Head Neck Surg. 2024 Oct 31. doi: 10.1001/jamaoto.2024.3737. PDF behind paywall
ndrew E Bluher 1 2, Timothy Kearney 3, Turaj Vazifedan 4, Cristina M Baldassari 5 6 7

Importance: Prior research has demonstrated an association between vitamin D deficiency and obstructive sleep apnea (OSA) in adults; however, its association with pediatric OSA is emerging.

Objective: To evaluate the association of vitamin D levels with obstructive Apnea-Hypopnea Index (AHI) in children with OSA.

Design, settings, and participants: This was a cross-sectional study of children aged 2 to 16 years with severe obstructive OSA (AHI ≥20 on polysomnogram) who were undergoing adenotonsillectomy at a tertiary care pediatric otolaryngology clinic from 2017 to 2022. Age, sex, race, body mass index, history of asthma, and season were considered in the analyses. Data were analyzed from September 3, 2021, to October 8, 2021.

Main outcomes and measures: Serum 25-hydroxyvitamin D (25[OH]D) levels were measured and assessed for correlation with polysomnography metrics. Fasting blood samples were collected and vitamin D deficiency was defined as 25(OH)D level less than 20 ng/mL.

Results: The consecutive sample included 72 patients (mean [SD] age, 6.7 [3.9] years; 34 [47.2%] females and 38 [52.8%] males). The mean (SD) AHI was 42.8 (25.5), and 35 participants (49.0%) had obesity. Vitamin D deficiency was present in 27 participants (37.5%). In univariate analysis, vitamin D deficiency was associated with younger age (difference, -5.0; 95% CI, -7.2 to -2.8), Black race (odds ratio [OR], 4.3; 95% CI, 1.4 to 14.3), female sex (OR, 4.8; 95% CI, 1.7 to 12.5), and higher obstructive AHI (difference, 13.8; 95% CI, 1.2 to 26.4). In multivariable analysis, vitamin D deficiency remained significantly associated with AHI. A 1.0-unit decrease in serum 25(OH)D levels was associated with an AHI increase of 0.7 (95% CI, 0.04 to 1.40).

Conclusions: The findings of this cross-sectional study indicate that vitamin D deficiency was common in children undergoing adenotonsillectomy for severe OSA and is significantly associated with increased OSA severity. Future research is needed on vitamin D supplementation and its association with any improvements in pediatric OSA treatment outcomes.

Some details of the study are at MedPageToday


Sleep Apnea and Vitamin D Deficiency - Mercola interview Gominak Feb 2024

86 minutes dual, connected epidemics: Low D, Sleep Apnea
 Transcript
Vitamin D is important for hibernation then should also be important for deep sleep
Vitamin D needed to stop movements (needed for deep sleep)
She has helped >5,000 people
Fit bits are very good at monitoring deep sleep
Vitamin D levels of 60-80 ng are needed if you do not have good B vitamins (oral or gut)
B vitamins are very important - only need 40-60 ng of Vitamin D
B vitamins also made by Microbiome - including gut
His notes on the video

  • There’s a synergy between vitamin D deficiency and poor sleep, both of which are at epidemic proportions in many parts of the world.
  • Lack of vitamin D causes impairment in your brain stem, which in turn can impair your sleep.
  • Vitamin D is also a crucial component required to make acetylcholine, a neurotransmitter that allows you to get “paralyzed” so that deep sleep can occur.
  • B vitamins also play an important role in sleep. Ideally, you need to normalize your gut microbiome so that your gut bacteria make all the B vitamins your body and brain need.
  • To normalize your gut microbiome, maintain a vitamin D level of 40 ng/mL or higher and take a B50 or B100 supplement for three months.

See also Restless Legs Syndrome dramatically reduced by vitamin D, etc


Review of Obstructive Sleep Apnea and Vitamin D - Feb 2024

Exploring the link between vitamin D deficiency and obstructive sleep apnea: A comprehensive review
Review J Sleep Res . 2024 Feb 27:e14166. doi: 10.1111/jsr.14166
Nan Yao 1, Chenyuan Ma 2, Ruixue Dou 3, Chao Shen 4, Ye Yuan 5, Wei Li 4, Jun Qu 1

Relevant Studies - presence and severity
Image

Relevant Studies - risk
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Despite the high prevalence and significant health burden of obstructive sleep apnea (OSA), its underlying pathophysiology remains incompletely understood. This comprehensive review explores the emerging connection between vitamin D deficiency and OSA, discusses potential mechanisms underlying this association, and explores the therapeutic implications of these findings. Recent research has consistently highlighted the high incidence of vitamin D deficiency among patients with OSA, which often occurs independently of geographical location. This suggests that factors beyond lack of sunlight exposure may be involved. This review also discusses how reduced vitamin D may be associated with more severe manifestations of OSA. In addition, it explores the potentiality of using vitamin D supplements as a therapeutic strategy for OSA, noting that some studies have found improvements in sleep quality and a reduction in OSA severity. Potential mechanisms are proposed, including the role of vitamin D deficiency in promoting inflammation, oxidative stress, hypoxia, impairing immune function, muscle function, and gene polymorphism of vitamin D receptors, all of which could contribute to the pathogenesis of obstructive sleep apnea. The paper underscores the need for future research to validate these observations, to determine optimal vitamin D supplementation dosage and duration, to explore potential side effects and risks, and to investigate potential interactions with other treatments.
 Download the PDF from VitaminDWiki


Obstructive sleep apnea and vitamin D: an updated systematic review and meta-analysis – Sept 2023

Hormones (Athens). 2023 Sep 14. doi: 10.1007/s42000-023-00481-3
Huai Heng Loh 1 2, Quan Hziung Lim 3, Waye Hann Kang 4, Anne Yee 5, Mei Ching Yong 6, Norlela Sukor 7 8

PURPOSE : Obstructive sleep apnea (OSA) is a chronic, sleep-related breathing disorder which leads to increased cardiovascular risks. Vitamin D deficiency is associated with various cardiometabolic complications, including increased cardiovascular morbidity and mortality. We aimed to analyze the difference in serum 25-hydroxyvitamin D (25-OHD) level, prevalence of vitamin D insufficiency and deficiency, and the effect of CPAP treatment on serum 25-OHD levels among adult patients with OSA.

Methods: We pooled data from 18 observational studies involving 5592 individuals. Baseline parameters that might have contributed to the significant differences observed were also analyzed.

Results: Patients with OSA had significantly lower serum 25-OHD levels (pooled d + - 0.74 [95% CI: - 1.19 to - 0.28], p < 0.01) and higher prevalence of vitamin D deficiency (pooled log (odds ratio) 0.98 [95% CI: 0.30 to 1.67], p < 0.01) compared to those without OSA. Subgroup analysis demonstrated that these differences were significant only in moderate OSA and severe OSA. Neither age nor BMI nor geographical latitude contributed significantly to the differences observed in serum 25-OHD levels. The use of CPAP did not lead to significant changes in serum 25-OHD levels.

Conclusion: Patients with OSA have lower serum 25-OHD levels with a higher prevalence of vitamin D deficiency, regardless of age or BMI, pointing to an independent association between vitamin D and OSA.


References
  1. Rundo JV (2019) Obstructive sleep apnea basics. Cleve Clin J Med 86(9 Suppl 1):2–9 - PubMed - DOI
  2. Epstein LJ et al (2009) Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med 5(3):263–276 - PubMed - DOI
  3. Surani SR (2014) Diabetes, sleep apnea, obesity and cardiovascular disease: why not address them together? World J Diabetes 5(3):381–384 - PubMed - PMC - DOI
  4. Gami AS, Caples SM, Somers VK (2003) Obesity and obstructive sleep apnea. Endocrinol Metab Clin North Am 32(4):869–894 - PubMed - DOI
  5. Holick MF (2009) vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol 19(2):73–78 - PubMed - DOI
  6. Wang TJ et al (2008) vitamin D deficiency and risk of cardiovascular disease. Circulation 117(4):503–511 - PubMed - DOI
  7. Cosentino N et al (2021) vitamin D and cardiovascular disease: current evidence and future perspectives. Nutrients 13(10):3603 - PubMed - PMC - DOI
  8. Holick MF et al (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 96(7):1911–1930 - PubMed - DOI
  9. Romano F et al (2020) vitamin D and sleep regulation: is there a role for vitamin D? Curr Pharm Des 26(21):2492–2496 - PubMed - DOI
  10. Archontogeorgis K et al (2018) The role of vitamin D in obstructive sleep apnoea syndrome. Breathe (Sheff) 14(3):206–215 - PubMed - DOI
  11. Loh HH, Sukor N (2023) Obstructive sleep apnea and vitamin D level: Has the dust settled? Clin Respir J 1(16). https://doi.org/10.1111/crj.13593
  12. Li X, He J, Yun J (2020) The association between serum vitamin D and obstructive sleep apnea: an updated meta-analysis. Respir Res 21(1):294 - PubMed - PMC - DOI
  13. Neighbors CLP et al (2018) vitamin D and obstructive sleep apnea: a systematic review and meta-analysis. Sleep Med 43:100–108 - PubMed - DOI
  14. Herzog R et al (2013) Are healthcare workers’ intentions to vaccinate related to their knowledge, beliefs and attitudes? A systematic review. BMC Public Health 13:154 - PubMed - PMC - DOI
  15. Lechat B et al (2022) Multinight prevalence, variability, and diagnostic misclassification of obstructive sleep apnea. Am J Respir Crit Care Med 205(5):563–569 - PubMed - DOI
  16. Bouloukaki I et al (2021) vitamin D deficiency in patients evaluated for obstructive sleep apnea: is it associated with disease severity? Sleep Breath 25(2):1109–1117 - PubMed - DOI
  17. Goswami U et al (2016) vitamin D concentrations and obstructive sleep apnea in a multicenter cohort of older males. Ann Am Thorac Soc 13(5):712–718 - PubMed - PMC - DOI
  18. Ma D et al (2020) The relationship of serum 25-hydroxyvitamin-D level with severity of obstructive sleep apnea in patients with type 2 diabetes mellitus. Diabetes Metab Syndr Obes 13:1391–1398 - PubMed - PMC - DOI
  19. Qiao Y et al (2018) Bone metabolic markers in patients with obstructive sleep apnea syndrome. Chin Med J (English Edition) 131(16):1898–1903
  20. Salepci B et al (2017) vitamin D deficiency in patients referred for evaluation of obstructive sleep apnea. J Clin Sleep Med 13(4):607–612 - PubMed - PMC - DOI
  21. Archontogeorgis K et al (2018) vitamin D levels in middle-aged patients with obstructive sleep apnoea syndrome. Curr Vasc Pharmacol 16(3):289–297 - PubMed - DOI
  22. Bhatt SP, Guleria R, Vikram NK (2021) The effect of the severity of obstructive sleep apnea on leukocyte telomere length, 25 hydroxy vitamin D, and parathyroid hormonal concentrations in Asian Indians. Front Neurol 12:682739 - PubMed - PMC - DOI
  23. Bozkurt NC et al (2012) The relation of serum 25-hydroxyvitamin-D levels with severity of obstructive sleep apnea and glucose metabolism abnormalities. Endocrine 41(3):518–525 - PubMed - DOI
  24. Erden ES et al (2014) Investigation of serum bisphenol A, vitamin D, and parathyroid hormone levels in patients with obstructive sleep apnea syndrome. Endocrine 45(2):311–318 - PubMed - DOI
  25. Kerley CP et al (2016) Serum vitamin D is significantly inversely associated with disease severity in Caucasian adults with obstructive sleep apnea syndrome. Sleep 39(2):293–300 - PubMed - PMC - DOI
  26. Kirac D et al (2019) Different VDR, VDBP genotypes and vitamin D levels may effect obstructive sleep apnea syndrome. Cell Mol Biol (Noisy-le-grand) 65(1):46–51 - PubMed - DOI
  27. Klobučníková K et al (2017) Carotid intima-media thickness is not associated with homocysteine and vitamin D levels in obstructive sleep apnea. Scand J Clin Lab Invest 77(4):263–266 - PubMed - DOI
  28. Kotsiou OS et al (2022) Association between Interleukin-6 and vitamin D serum levels in patients with obstructive sleep apnea syndrome and impact of long-term continuous positive airway pressure therapy on biomarker levels. Respir Physiol Neurobiol 296:103806 - PubMed - DOI
  29. Liguori C et al (2015) Continuous positive airway pressure treatment increases serum vitamin D levels in male patients with obstructive sleep apnea. J Clin Sleep Med 11(6):603–607 - PubMed - PMC - DOI
  30. Mete T et al (2013) Obstructive sleep apnea syndrome and its association with vitamin D deficiency. J Endocrinol Invest 36(9):681–685 - PubMed
  31. Sadaf S et al (2021) Effect of obstructive sleep apnea on bone mineral density. Turk Toraks Dergisi / Turk Thorac J 22(4):301–310 - DOI
  32. Siachpazidou DI et al (2021) Serum vitamin D levels in patients with obstructive sleep apnea syndrome and level changes after continuous positive airway pressure therapy. Sleep Breath 25(2):657–668 - PubMed - DOI
  33. Toujani S et al (2017) vitamin D deficiency and interleukin-17 relationship in severe obstructive sleep apnea–hypopnea syndrome. Ann Thorac Med 12(2):107–113 - PubMed - PMC - DOI
  34. Theorell-Haglöw J et al (2018) Changes of vitamin D levels and bone turnover markers after CPAP therapy: a randomized sham-controlled trial. J Sleep Res 27(4):e12606 - PubMed - DOI
  35. Liguori C et al (2017) vitamin D status of male OSAS patients improved after long-term CPAP treatment mainly in obese subjects. Sleep Med 29:81–85 - PubMed - DOI
  36. Ayyıldız F et al (2021) The effects of vitamin D supplemantation on prognosis in patients with mild obstructive sleep apnea syndrome. Turk J Med Sci 51(5):2524–2533 - PubMed - DOI
  37. Kerley CP et al (2017) vitamin D improves selected metabolic parameters but not neuropsychological or quality of life indices in OSA: a pilot study. J Clin Sleep Med 13(1):19–26 - PubMed - PMC - DOI
  38. Gronewold J et al (2019) Sleep-disordered breathing in hospitalized geriatric patients with mild dementia and its association with cognition, emotion and mobility. Int J Environ Res Public Health Electron Resour 16(5):09
  39. Archontogeorgis K et al (2018) Metabolic syndrome and vitamin D levels in patients with obstructive sleep apnea syndrome. Metab Syndr Relat Disord 16(4):190–196 - PubMed - DOI
  40. Upala S, Sanguankeo A (2015) Association between 25-hydroxyvitamin D and obstructive sleep apnea: a systematic review and meta-analysis. J Clin Sleep Med 11(11):1347–1347 - PubMed - PMC - DOI
  41. Bennour I et al (2022) vitamin D and obesity/adiposity–a brief overview of recent studies. Nutrients 14(10):2049 - PubMed - PMC - DOI
  42. Moy FM, Bulgiba A (2011) High prevalence of vitamin D insufficiency and its association with obesity and metabolic syndrome among Malay adults in Kuala Lumpur. Malaysia BMC Public Health 11:735 - PubMed - DOI
  43. Vranic L, Mikolasevic I, Milic S (2019) vitamin D deficiency: consequence or cause of obesity? Medicina (Kaunas) 55(9):541 - PubMed - DOI
  44. Duan L et al (2020) Effects of vitamin D supplementation on general and central obesity: results from 20 randomized controlled trials involving apparently healthy populations. Ann Nutr Metab 76(3):153–164 - PubMed - DOI
  45. Romero-Corral A et al (2010) Interactions between obesity and obstructive sleep apnea: implications for treatment. Chest 137(3):711–719 - PubMed - PMC - DOI
  46. Riha RL (2009) Genetic aspects of the obstructive sleep apnoea/hypopnoea syndrome – is there a common link with obesity? Respiration 78(1):5–17 - PubMed - DOI
  47. Kuvat N, Tanriverdi H, Armutcu F (2020) The relationship between obstructive sleep apnea syndrome and obesity: a new perspective on the pathogenesis in terms of organ crosstalk. Clin Respir J 14(7):595–604 - PubMed - DOI
  48. Fan Z et al (2019) Independent association of vitamin D and insulin resistance in obstructive sleep apnea. Ann Endocrinol (Paris) 80(5–6):319–323 - PubMed - DOI
  49. Gonzalez-Muniesa P et al (2017) Obesity. Nat Rev Dis Primers 3:17034 - PubMed - DOI
  50. Thacher TD, Clarke BL (2011) vitamin D insufficiency. Mayo Clin Proc 86(1):50–60 - PubMed - PMC - DOI
  51. Lopez A-G, Kerlan V, Desailloud R (2021) Non-classical effects of vitamin D: non-bone effects of vitamin D. Ann Endocrinol 82(1):43–51 - DOI
  52. Maniero C et al (2011) Primary hyperparathyroidism with concurrent primary aldosteronism. Hypertension 58(3):341–346 - PubMed - DOI
  53. Gabryelska A et al (2020) Patients with obstructive sleep apnea present with chronic upregulation of serum HIF-1alpha protein. J Clin Sleep Med 16(10):1761–1768 - PubMed - PMC - DOI
  54. Ben-Shoshan M et al (2007) 1alpha,25-Dihydroxyvitamin D3 (calcitriol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cells. Mol Cancer Ther 6(4):1433–1439 - PubMed - DOI
  55. McCarty DE et al (2014) The link between vitamin D metabolism and sleep medicine. Sleep Med Rev 18(4):311–319 - PubMed - DOI
  56. Patil SP et al (2007) Adult obstructive sleep apnea: pathophysiology and diagnosis. Chest 132(1):325–337 - PubMed - DOI
  57. Moraes W et al (2014) Effects of aging on sleep structure throughout adulthood: a population-based study. Sleep Med 15(4):401–409 - PubMed - DOI
  58. Silva MDS et al (2022) Associations of the severity of obstructive sleep apnea with age-related comorbidities: a population-based study. Front Neurol 13:802 - DOI
  59. Martin S et al (1997) The effect of age, sex, obesity and posture on upper airway size. Eur Respir J 10(9):2087–2090 - PubMed - DOI
  60. Kweder H, Eidi H (2018) vitamin D deficiency in elderly: risk factors and drugs impact on vitamin D status. Avicenna J Med 8(4):139–146 - PubMed - PMC - DOI
  61. Gallagher JC (2013) vitamin D and aging. Endocrinol Metab Clin North Am 42(2):319–332 - PubMed - PMC - DOI
  62. Ebeling PR et al (1992) Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women. J Clin Endocrinol Metab 75(1):176–182 - PubMed
  63. Chalcraft JR et al (2020) vitamin D synthesis following a single bout of sun exposure in older and younger men and women. Nutrients 12(8):2237 - PubMed - PMC - DOI
  64. Norman AW (2006) Minireview: vitamin D receptor: new assignments for an already busy receptor. Endocrinology 147(12):5542–5548 - PubMed - DOI
  65. Mitri J, Muraru MD, Pittas AG (2011) vitamin D and type 2 diabetes: a systematic review. Eur J Clin Nutr 65(9):1005–1015 - PubMed - PMC - DOI
  66. Gedik O, Akalin S (1986) Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man. Diabetologia 29(3):142–145 - PubMed - DOI
  67. Barchetta I, Cimini FA, Cavallo MG (2020) vitamin D and metabolic dysfunction-associated fatty liver disease (MAFLD): an update. Nutrients 12(11):3302 - PubMed - PMC - DOI
  68. Bikle DD, Schwartz J (2019) vitamin D binding protein, total and free vitamin D levels in different physiological and pathophysiological conditions. Front Endocrinol (Lausanne) 10:317 - PubMed - DOI
  69. Pazarli AC, Ekiz T, İnönüKöseoğlu H (2019) Association between 25-hydroxyvitamin D and bone mineral density in people with obstructive sleep apnea syndrome. J Clin Densitom 22(1):39–46 - PubMed - DOI
  70. Qiao Y et al (2018) Bone metabolic markers in patients with obstructive sleep apnea syndrome. Chin Med J (Engl) 131(16):1898–1903 - PubMed - DOI
  71. Ragia G et al (2019) Genetics of obstructive sleep apnea: vitamin D receptor gene variation affects both vitamin D serum concentration and disease susceptibility. OMICS 23(1):45–53 - PubMed - DOI
  72. Sadaf S et al (2021) Effect of obstructive sleep apnea on bone mineral density. Turk Thorac J 22(4):301–310 - PubMed - PMC - DOI
  73. Archontogeorgis K et al (2022) vitamin D levels in patients with overlap syndrome, is it associated with disease severity? J Pers Med 12(10):1693 - PubMed - PMC - DOI
  74. Archontogeorgis K et al (2019) Reduced serum vitamin D levels are associated with insulin resistance in patients with obstructive sleep apnea syndrome. Medicina (Kaunas) 55(5):174 - PubMed - DOI
  75. Theorell-Haglow J et al (2018) Changes of vitamin D levels and bone turnover markers after CPAP therapy: a randomized sham-controlled trial. J Sleep Res 27(4):e12606 - PubMed - DOI
  76. Siachpazidou DI et al (2020) 25-hydroxyvitamin D levels in patients with obstructive sleep apnea and continuous positive airway pressure treatment: a brief review. Sleep Sci 13(1):78–83 - PubMed - PMC

10% of Americans have sleep apnea (but only half are aware of it)

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Attached files

ID Name Comment Uploaded Size Downloads
20932 Interview-StashaGominak-PromotingSleepByOptimizingVitaminDLevels.pdf admin 08 Mar, 2024 271.27 Kb 118
20873 Apnea 2.png admin 28 Feb, 2024 228.48 Kb 225
20872 Sleep apnea 1.png admin 28 Feb, 2024 257.64 Kb 241
20871 obstructive sleep apnea review_CompressPdf.pdf admin 28 Feb, 2024 159.33 Kb 84