Loading...
 
Toggle Health Problems and D

Severe childhood COVID-19 associated with Vitamin D deficiency (hospital in Turkey) – March 2021

The association between vitamin D levels and the clinical severity and inflammation markers in pediatric COVID-19 patients: single-center experience from a pandemic hospital

European Journal of Pediatrics (2021) https://doi.org/10.1007/s00431-021-04030-1
Elvan Bayramoğlu, Gülşen Akkoç, Ayşe Ağbaş, Özlem Akgün, Kamer Yurdakul, Hatice Nilgün Selçuk Duru & Murat Elevli
Image

VitaminDWiki

Note: No COVID-19 vaccine is expected to be available to children until 2022
Consider increasing vitamin D levels in children so as to reduce COVID-19 risk until vaccine is available

Items in both categories Virus and Infant/Child:

COVID-19 treated by Vitamin D - studies, reports, videos

As of Oct 24, 2021, the page had:  34 trials 6 trial results,   27 meta-analyses and reviews,   64 observations,   36 recommendations,   55 associations,  89 speculations,  48 videos   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   26 risk factors are ALL associated with low Vit D,   Recent Virus pages   Fight COVID-19 with 50K Vit D weekly   Vaccines

 Download the PDF from VitaminDWiki

Vitamin D has an immunomodulating property that regulates the inflammatory response. In this study, the aim was to evaluate the relationship between vitamin D levels and clinical severity and inflammation markers in children and adolescents with COVID-19. The clinical and laboratory records of 103 pediatric cases with COVID-19, whose vitamin D levels had been measured, were retrospectively reviewed. The cases were divided into groups according to their clinical severity (asymptomatic, mild, and moderate-to-severe) and vitamin D levels. The moderate-to-severe clinical group had significantly higher inflammation markers (CRP, procalcitonin, fibrinogen, D-dimer) and a lower lymphocyte count compared to both the mild and asymptomatic groups. The 25 OH vitamin D levels were also significantly lower (p < 0.001), and the ratio of vitamin D deficiency was 70.6% in the moderate-to-severe group. The vitamin D–deficient group had a significantly higher age and fibrinogen levels while also having a lower lymphocyte count compared to the insufficient and normal groups. The 25 OH vitamin D level was correlated positively with the lymphocyte count (r = 0.375, p = <0.001), and negatively with age (r = −0.496, p = <0.001), CRP (r = −0.309, p = 0.002) and fibrinogen levels (r = −0.381, p = <0.001). In a logistic regression analysis, vitamin D deficiency, D-dimer, and fibrinogen levels on admission were independent predictors of severe clinical course.

Conclusion: This study revealed an association between vitamin D deficiency and clinical severity, in addition to inflammation markers in pediatric COVID-19 cases. Prophylactic vitamin D supplementation may be considered, especially in the adolescent age group.

What is Known:

  • The pathology of COVID-19 involves a complex interaction between the SARS-CoV-2 and the immune system. Hyperinflammation/cytokine storm is held responsible for the severity of the disease.
  • Vitamin D has multiple roles in the immune system that can modulate the body reaction to an infection.

What is New:

  • Clinically more severe group had significantly lower vit D levels and significantly higher inflammation markers.
  • Lower 25 OH vit D levels were associated with higher inflammation markers, suggesting an important role of vitamin D in the clinical course of COVID-19 in children and adolescents probably by regulating the systemic inflammatory response.
Title change made AUG 2021 caused the visitor count to reset.
There have actually been 1147 visitors to this page since it was originally made


Created by admin. Last Modification: Sunday August 29, 2021 19:03:18 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
15429 Pediatric COVID-19.jpg admin 13 Apr, 2021 19:31 70.01 Kb 397
15428 pediatric COVID-19 March 31.pdf PDF 2021 admin 13 Apr, 2021 19:31 331.92 Kb 108
See any problem with this page? Report it (FINALLY WORKS)