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Risk of Major Depressive Disorder increased 2.2 X by a poor Vitamin D receptor – Oct 2020

BsmI-ApaI-TaqI TAC (BAt) Haplotype of Vitamin D Receptor Gene Is Associated with Increased Risk of Major Depressive Disorder

J Mol Neurosci, . 2020 Oct 9, doi: 10.1007/s12031-020-01719-0
Munn-Sann Lye 1 2, Yin-Sim Tor 3 4, Yin-Yee Tey 3, Aishah Shahabudin 3, Su-Peng Loh 5, Normala Ibrahim 6, Johnson Stanslas 7, Rozita Rosli 8, King-Hwa Ling 8

Heritability of major depressive disorder (MDD) is between 36 and 44%, suggesting that up to nearly half of the phenotypic variability is attributable to genes. A number of genetic polymorphisms have been shown to predispose certain individuals to depression. Of particular interest are the polymorphisms of the vitamin D receptor (VDR) gene. Although the VDR gene has been well characterized and a vast number of polymorphisms have been identified, the association between BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) single-nucleotide polymorphisms (SNPs), together with their haplotypes, and MDD risk have yet to be established. We conducted a matched case-control study with a total of 600 participants comprising 300 major depressive disorder (MDD) cases and 300 controls matched by age, gender and ethnicity in a 1:1 ratio, in four public hospitals in Kuala Lumpur and Selangor. Three adjacent SNPs of the VDR gene-BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236)-were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Odds ratios and 95% confidence intervals (CIs) were obtained from conditional logistic regression using Stata 16. Linkage disequilibrium and haplotype association with MDD were analyzed using the online SNPStats program. None of the genotypes of the three SNPs was significantly associated with risk of developing MDD after adjusting for confounding factors. However, the TAC (BAt) haplotype was associated with increased odds of MDD (adjusted OR = 2.17, 95% CI = 1.30-3.61, p = 0.003) using CCT (baT) as reference haplotype. The findings suggest that the BsmI-ApaI-TaqI TAC (BAt) haplotype of the VDR gene increases susceptibility to MDD.


Depression substantially reduced by Vitamin D, Omega-3, Magnesium, etc – many studies includes

14+ VitaminDWiki pages with ANXIETY in title
This list is automatically updated

Items found: 14
Title Modified
Half as much anxiety and sleep problems if get lots of vitamin D from food (excluded getting D from supplements) – Feb 2024 23 Feb, 2024
Anxiety, Vitamin D, Omega-3 - many studies 23 Feb, 2024
Low Vitamin D is associated with risk of Depression 5X, Stress 4.8 X, and Anxiety 3.9 X (Saudi Arabia college students) – July 2023 29 Jul, 2023
Parkinson’s – Vitamin D, bone density, insomnia, falls, poor sleep, anxiety – March 2019 10 May, 2023
Anxiety and Depression decreased in senior prediabetics with weekly 25,000 IU of Vitamin D – RCT Sept 2022 22 Dec, 2022
Depression and Anxiety treatment with Vitamin D - probable molecular pathways - June 2022 21 Dec, 2022
Coronary Artery Disease Chest Pain, Anxiety, and Fatigue associated with low vitamin D – Oct 2022 07 Oct, 2022
Anxiety, depression, and suicide have recently surged (Note: Vitamin D, Omega-3, and Magnesium help) – May 2022 29 May, 2022
General Anxiety Disorder treated by weekly Vitamin D (50,000 IU -Omega-3, Mg also help) – Sept 2019 09 Dec, 2019
Omega-3 reduces Depression. Anxiety, Stress, PTSD, etc. – Aug 2018 02 Sep, 2019
Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018 10 Nov, 2018
Anxiety severity reduced if more than 2 grams of Omega-3 – meta-analysis Sept 2018 19 Sep, 2018
Why is teen anxiety increasing so much (no mention of Magnesium, Vitamin D nor Omega-3) – Oct 2017 11 Oct, 2017
Salmon intervention (vitamin D and Omega-3) improved heart rate variability and reduced anxiety – Nov 2014 11 Feb, 2015

Intervention of Vitamin D for Depression

Meta-analyses of Vitamin D and Depression

Depression summary

Some recent publications

Items in both categories Depression and Vitamin D Receptor


Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators


Created by admin. Last Modification: Saturday October 10, 2020 13:53:50 GMT-0000 by admin. (Version 3)