Toggle Health Problems and D

Respiratory Tract Infection visits 2.5 less likely with vitamin D: Pregnancy 2000 IU, Infant 800 IU – RCT Oct 2014

Reduced primary care respiratory infection visits following pregnancy and infancy vitamin D supplementation: a randomised-controlled trial

Acta Paediatrica DOI: 10.1111/apa.12819
Cameron C. Grant1,*, Suhina Kaur2, Ellen Waymouth1, Edwin A. Mitchell1, Robert Scragg3, Alec Ekeroma4, Alistair Stewart3, Julian Crane5, Adrian Trenholme6 andCarlos A. Camargo Jr.7

To determine whether vitamin D supplementation reduces primary care visits for acute respiratory infection (ARI).

A randomised, double-blind, placebo-controlled trial was conducted in New Zealand and powered to determine the vitamin D dose needed to achieve normal vitamin D status during infancy. Healthy pregnant women, from 27 weeks gestation to birth, and their infants, from birth to age 6 months, were assigned to placebo or one of two dosages of daily oral vitamin D3. Woman/infant pairs were randomised to: placebo/placebo, 1000IU/400IU, or 2000IU/800IU.For this ad hoc analysis, the primary care records of enrolled children were audited to age 18 months.

Two-hundred-and-sixty pregnant women were randomised to placebo (n=87), lower-dose (n=87) or higher-dose (n=86) vitamin D3. In comparison with the placebo group (99%), the proportion of children making any ARI visits was smaller in the higher-dose (87%, P=0.004), but not the lower-dose vitamin D3 group (95%, P=0.17). The median number of ARI visits/child was less in the higher-dose vitamin D3 group from age 6-18 months (placebo 4, lower-dose 3, higher-dose 2.5; P=0.048 for higher-dose vitamin D3 vs. placebo).

Vitamin D3 supplementation during pregnancy and infancy reduces primary care visits for ARI during early childhood.

This article is protected by copyright. All rights reserved.
Publisher rents PDF for $6

See also VitaminDWiki

There have been 11843 visits to this page
Respiratory Tract Infection visits 2.5 less likely with vitamin D: Pregnancy 2000 IU, Infant 800 IU – RCT Oct 2014        
1354 visitors, last modified 08 Oct, 2023,
Printer Friendly Follow this page for updates