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Prostate cancer patients in Jamaica were 5X more likely to die of PC if low vitamin D - Sept 2022

Vitamin D Deficiency at Diagnosis Increases All-Cause and Prostate Cancer-specific Mortality in Jamaican Men

022 Jan-Dec;29 doi: 10.1177/10732748221131225.
Donovan McGrowder 1, Marshall K Tulloch-Reid 2, Kathleen C M Coard 1, Afette M McCaw-Binns 3, Trevor S Ferguson 2, William Aiken 4, Leroy Harrison 5, Simon G Anderson 6, Maria D Jackson 3

Background: 25 hydroxyvitamin D [25(OH)D] and serum calcium have been associated with incident prostate cancer (PCa). However, there is limited data on whether these metabolites predict survival in men of African descent, a population disproportionately affected by PCa. We studied the relationship of 25(OH)D at PCa diagnosis with all-cause and cancer-specific mortality among Jamaican men and examined whether serum calcium modified any associations.

Methods: Serum 25(OH)D from 152 Jamaican men with incident PCa within the Prostate Cancer Risk Evaluation (PROSCARE) study were re-evaluated approximately 11 years after enrollment. 25(OH)D analyses were stratified using the using Holick criteria. PCa-specific and all-cause mortality were examined in Kaplan-Meier survival curves and Cox regression models adjusted for age, body mass index (BMI), smoking and Gleason score. Restricted cubic splines evaluated nonlinear associations. Serum calcium was assessed as an effect modifier of the association between 25(OH)D and mortality.

Results: Of cases with available 25(OH)D, 64 men with PCa survived, 38 deaths were PCa specific and 36 died of other causes. At baseline, 9.9% of cases were vitamin D deficient and 61.2% were vitamin D sufficient. Compared to 25(OH)D sufficient men, those with 25(OH)D <20.0 ng/mL concentrations were associated with higher PCa-specific mortality (adjusted HR, 4.95; 95% CI, 1.68, 14.63, P = .004) and all-cause mortality (adjusted HR, 2.40; 95%CI, 1.33, 4. 32, P = .003). Serum calcium was not associated with survival and did not modify any associations with 25(OH)D.

Conclusions: 25(OH)D deficiency at PCa diagnosis predicted decreased survival for overall and PCa-specific cancer in Caribbean men of African ancestry.
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VitaminDWiki - 9 studies in both categories Prostate Cancer and Skin - Dark

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VitaminDWiki - 12 studies in both categories Dark Skin and Mortality

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VitaminDWiki - 7 studies in both categories Dark Skin and Vitamin D Receptor

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Dark-skin with CANCER in title (31 as of Oct 2022)

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Items found: 31
Title Modified
Prostate cancer patients in Jamaica were 5X more likely to die of PC if low vitamin D - Sept 2022 01 Oct, 2022
Newly diagnosed Children with Cancer have low vitamin D, especially if black - May 2022 16 Jun, 2022
Cancer continues to be more deadly for Blacks than Whites (hint – low Vitamin D) – May 2022 30 May, 2022
Cancer of breast is highest in dark-skinned women (low Vitamin D: dark skin and obese) - Feb 2022 12 Feb, 2022
Cancers and Vitamin D Receptors, including change with race – Feb 2021 24 Oct, 2021
Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020 19 Feb, 2021
Deaths after Cancer Surgery higher in blacks (probably low vitamin D) – Dec 2020 10 Jan, 2021
Multiple Myeloma (blood cell cancer) treated by vitamin D - many studies 14 Jun, 2019
Blacks are more obese, have lower Vitamin D, and have more Cancer etc. than whites – Feb 2018 03 May, 2018
Hypothesis: Blacks get more cancer than whites due to lower levels of vitamin D – June 2012 03 May, 2018
Prostate Cancer risk in black men increased 2X having poor Vitamin D Binding Protein – July 2017 20 Nov, 2017
Breast cancer in blacks – 5X increased risk of triple negative if low vitamin D – Oct 2017 01 Nov, 2017
Breast cancer worse for black women – Sept 2011 19 Aug, 2017
Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017 06 Mar, 2017
Aggressive Prostate Cancer in blacks with low vitamin D – 7X more likely if added Calcium – Jan 2017 28 Dec, 2016
Head and Neck Cancer associated with low vitamin D, especially with blacks - April 2012 17 Nov, 2016
2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013 14 Nov, 2016
Higher rate of prostate cancer in AA may decrease if take vitamin D – July 2016 07 Jul, 2016
Prostate Cancer incidence and death 2X more often among black men (vitamin D not mentioned) - July 2015 30 Jul, 2015
Kidney Cancer differences with skin color probably due to vitamin D differences – May 2015 25 May, 2015
Tanning potential predicts risk of Prostate Cancer in Blacks – Nov 2014 02 Jan, 2015
Cancer patients at high risk of vitamin D deficiency were not tested as often (paradoxically) – July 2014 12 Aug, 2014
Colon cancer more likely in blacks due to differences in Vitamin D genes (wonder if more Vitamin D would help) – May 2014 21 May, 2014
Barefoot on mega doses of vitamin D and his book on Cancer 10 Apr, 2014
Hypothesis - Dark skin evolved to avoid skin cancer - Feb 2014 02 Mar, 2014
Breast cancer more deadly for blacks than whites 13 Feb, 2014
Skin cancer risk and vitamin D from sun both decrease with darker skin – March 2013 10 Nov, 2013
Hypothesis: Vitamin D is related to breast cancer racial disparities in the US - Sept 2012 08 Jul, 2013
Genes may account for some of AA Breast Cancer – April 2012 08 Jul, 2013
More US deaths due to cancer than heart if dark skinned – Sept 2012 18 Sep, 2012
Low vitamin D in blacks increases colorectal cancer deaths 40 percent – Cancer Oct 2010 23 Oct, 2010

Created by admin. Last Modification: Saturday October 1, 2022 23:46:34 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
18530 PC mortality.jpg admin 01 Oct, 2022 21:33 25.52 Kb 55
18529 PC mortality_CompressPdf.pdf PDF 2022 admin 01 Oct, 2022 21:32 567.59 Kb 47