Possible large Vitamin D intervention trial: Iceland, Saudi Arabia etc.

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See also in VitaminDWiki

• Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022
• 4 X fewer visits to Dr. after getting high level of vitamin D (Interview with transcript) - Jan 3, 2022
• COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
  • Does Less Sun mean More Disease video mentions his experience

• COVID, Cancer, etc. are Vitamin D low-hanging-fruit – Editorial June 2022
• Chance of dying in hospital cut in half by just 10 ng higher level of Vitamin D – April 2016
• Turkey gave 400 IU vitamin D to all infants and reduced Rickets by 60X - 2011
  • Rickets almost eradicated in counties giving free Vitamin D, perhaps the world can learn – Dec 2019
• Fortification with Vitamin D works – 16 studies of Danish experience – July 2021
• Proof that Vitamin D Works has the following list

ADHD,  Alcoholic Liver Cirrhosis,  ALS,  Alzheimer's,  Antibiotic Use in Seniors,  Asthma,  Autism,  Autoimmune Diseases,   Back pain,  Blood Cell Cancer,   Breast Cancer,   Cardiovascular,  Cholesterol,  Chronic Hives,  Chronic Kidney Disease,  Cluster Headaches,  Congestive Heart Failure (Infants),  COPD,  Crohn's Disease,  C-Section and Pregnancy Risks,  Cystic Fibrosis,  Depression,   Diabetes,  Diabetic Neuropathy,  Eczema,   Falls,  Fatigue,  Fatty Liver (Child),  Fibromyalgia,  Gestational Diabetes,  Gingivitis,  Growing Pains,  Hay Fever,  Heart Attack,  Hemodialysis,  Hepatitis-C,   Hip Fractures,  Hypertension,  Influenza,  Irritable Bowel Syndrome,  Ischemic Stroke,  Knee Osteoarthritis,  Leg Ulcers,   Low Birth Weight,  Lupus,  Male Infertility,   Menstrual Pain,  Metabolic Syndrome,  Middle Ear Infection (Infants),  Mite Allergy,  Multiple Sclerosis,  Non-Alcoholic Fatty Liver Disease,  Osteoarthritis,  Parkinson's Disease,  Perinatal Depression,  Pneumonia (Ventilator-associated),  Poor Sleep,  PreDiabetes,  Preeclampsia,  Pre-term Birth,  Prostate Cancer,  Quality of Life,   Raynaud's Pain,   Respiratory Tract Infection,  Restless Leg Syndrome,   Rheumatoid Arthritis,   Rickets,  Sarcopenia,  Sepsis,  Short Neonates,  Sickle Cell,  Stronger Senior Muscles,  Survive ICU,  TB,  Trauma Death,  Traumatic Brain Injury,  Tuberculosis,  Ulcerative Colitis,  Urinary Tract Infection,  Vaginosis,  Vertigo,  Warts,  Weight Loss

Select pink box in the upper right to select a language
Click on underlined items for details

Health Problem	Treat Prevent	Reduction by Vit D	RCT = Randomized Controlled Trial    * = link to additional RCT CT = Clinical Trial
Hypertension	T P	149 to 142 mm Hg HT risk reduced 10X	RCT*  *, 2400 IU.  100,000 IU* When Vitamin D > 40 ng
Cardiovascular after attack	T	32 % fewer deaths	CT 1000 IU
Diabetes Type 1	P	85 %	12,000 kids, 2000 IU
Diabetes Type 2	T	62 %	RCT* CRP reduction, 4000 IU Injection is far better - RCT * RCT 50,000 IU/2weeks + probiotics RCT 5,000 IU daily 6 months
Back Pain	T	95 % reduced 50%	5000/10000 IU 60,000 IU weekly
Influenza	P	90 %	RCT *, 2000 IU
Falls	P	50%	RCT, 100,000 IU monthly RCT with Meals on Wheels 2016
Hip Fractures	P	30 %	RCT * 800 IU
Rickets	P	98 %	Turkey, 400 IU NOT RCT, given to all children
Raynaud's Syndrome	T	40 %	RCT, visual scale, 20000 IU Avg
Menstrual pain	P	76 %	RCT, 7000 IU Avg, 70% reduction 2018 PMS reduced by half
Pregnancy risks	P	50 %	RCT, 4000 IU
C-section, unplanned	P	50 %	RCT, 4000 IU, small study
Low birth weight	P	60 %	RCT * 1000 IU of D2
TB	P	60 %	RCT, 800 IU
Breast Cancer	P	60 %	RCT, 1100 IU (2007)
Rheumatoid Arthritis pain	T	40 %	RCT, 500 IU, added to prescription
Cystic Fibrosis	T	75 % 2nd study improved	RCT, pilot 4X fewer deaths 250,000 IU RCT, pilot 8,200 IU
Chronic Kidney	T	90 to 70 PTH	RCT, 3500 IU,
Respiratory Tract Infection	P	63 %	3 RCT, 4000 IU 1 year 2nd 2000/800 IU 20,000 IU weekly
Lupus	T T	zero flares Pain reduced	Loading then 100,000 IU monthly, RCT too RCT 4,000 IU
Sickle Cell	T	Less pain	RCT, up to 100,000 IU/week
Leg ulcer healing	T	4X faster	RCT, 50,0000 IU/week, small study
Traumatic Brain Injury	T	2X	RCT, 20,0000 IU/day with progesterone
Parkinson's Disease	T	Stabilized	RCT, 1200 IU/day
Multiple Sclerosis	P T	68% 95% were CURED	RCT, 7100 IU prevent pre-MS ==> MS 20,000 to 140,000 IU/day
Congestive Heart Failure	T	90 %	RCT, 1000 IU infants (also: Adults, not RCT)
Middle Ear Infection	P	30 %	RCT, 1000 IU infants
Gingivitis	T	88 %	RCT, 2000 IU
Muscle in seniors	T	17 % more muscle	RCT, 4000 IU
Antibiotic use when >70y	T	47 %	RCT, 60,000 IU monthly
Infants taller	Benefit	1 cm tall	RCT, 50,000 IU weekly, for 8 weeks while pregnant
Gestational Diabetes	T	Reduced 3X	RCT, 2 doses of 50,000 IU
After Heart Attack	T	+6% ejection fraction	RCT, 800,000 IU one time
Prostate Cancer	T	Fewer +cores	RCT, 4000 IU (2012)
Asthma	P   T	Reduced symptoms	RCT, 60K IU/month; RCT 50K IU/week Need good D at 4 weeks into preg.
Depression	T	Reduced	RCT 300,000 IU injection RCT 1500 IU helped Prozac RCT 50,000 IU weekly, elderly
Low vitamin D while breastfed	P	All infants > 20 mg	RCT, 5,000 IU
Fibromyalgia	T	Half of many still has Fibro	RCT, 30-48 ng RCT 50K IU/week
Hives, Chronic	T	Reduced 40%	RCT, 4000 IU added
Cholesterol	T	Reduced 4 mg	RCT, 400 IU + Ca
Weight Loss	T	lost 5 more lbs	RCT, 2000 IU +diet +exercise
Gestational Diabetes	P	40%	RCT * , 5,000 IU
Chronic Obstructive Pulmonary Disease	T	17X improvement	CT, 50,000 IU weekly RCT 100,000 IU monthly
Asthma	T	1/2 Asthma attacks	RCT >42 mg of vitamin D
Quality of Life (QoL)	T	Nursing Home QoL	CT, 4,000 IU in daily bread
Death of Critically Ill Patients	T	20% increase in survivability	RCT 540 K IU loading than 90K monthly
Restless Leg Syndrome	T	Score 26 ==> 10	CT, Vitamin D dose size not stated in abstract
Hepatitis-C	T	Aided normal drugs	RCT 2.000 IU
Crohn's disease	T	improved when > 30 ng 2nd study fewer relapses	RCT 2,000 IU 10,000 IU RCT
Pre-term birth	P	2.5X decrease, also: fewer c-section & better Apgar	RCT 2,000 IU India
Cluster headaches	T	CH eliminated in 60%	10,000 IU, Mg, Omega-3, etc
Autism	T	80% improved	CT 300 IU/kg/day for 3 months
PreDiabetes	T	~20% reduced	RCT 60,000 IU/month
Weight loss: Overweight and Obese	T	12 lbs in 6 months	RCT 100,000 IU/month
Sarcopenia = muscle loss	T	27% increase	RCT 1,000 IU
Growing Pains	T	60% decrease	~100,000 IU/month -NOT RCT 2nd study, similar results
Osteoarthritis pain	T	60% decrease	50,000 IU/weekly - NOT RCT
ALS	T	helped	2,000 IU - NOT RCT, given to all
Vertigo	T	3X reduction if raised > 10ng	600,000 IU load, then maint. NOT RCT, given to all
Warts	T	80% eliminated injection	NOT RCT 60,000 IU/injection
Metabolic Syndrome	P	reduced 44% when VitD increased by 30 ng	NOT RCT, given to all
Hay fever	P	reduced 48%	RCT   1,000 IU for 30 days
Preeclampsia	P	Recurrance cut in half 3 RCT 3.6 X less likely if > 30 ng	50,000 IU every 2 weeks 4,000 IU daily
Blood cell cancer Multiple Myeloma	T	Survival 90% vs 50%	10,000 IU/week NOT RCT, given to all
Irritable Bowel Syndrome	T	Reduced	3,000 IU spray RCT
Urinary Tract Infection	P	50% reduction	RCT 20,000 IU weekly
Mite Allergy	P	5X reduction	RCT 2,000 IU preg, 800 IU child
Perinatal depression (depression near birth)	T	50% reduction	RCT 2,000 IU for just a few weeks
Vaginosis	T	10X reduction	RCT 2,000 IU
Eczema	T	Reduced	2 RCT 1,600 IU
Non-Alcoholic Fatty Liver Disease	T	Reduced	RCT 20,000 IU weekly
Knee Osteoartiritis	T	Pain Reduced	RCT 60,000 IU monthly after loading dose
Tuberculosis	T	Faster Recovery	RCT single 450,000 IU dose
Stroke - Ischemic	T	Faster Recovery	RCT single 600,000 IU injection RCT single 300,000 IU injection
Sepsis	T	Reduce ICU and Hospital length of stay by 7 days each	RCT 400,000 IU
Trauma deaths	T	50% fewer deaths	Vitamin D & Glutamine NOT RCT, given to all
Hemodialysis patients	T	helped	50,000 IU weekly NOT RCT, given to all
Fatty liver - child	T	2 X reduction	RCT  Vitamin D & DHA
Fatigue	T	Reduced	100,000 IU single dose NOT RCT, given to all
Sleep Disorders	T	Nicely treated	RCT  50.000 IU bi-weekly
Pneumonia (Ventilator-associated)	T	RCT   Death rate cut in half	300,000 IU injection
Infertile males	T	birth rate doubled	RCT   300,000 IU + maint
Waist size	T	Waist size reduced 3 cm	100,000 IU loading + maint for 6 months for those with Metabolic Syndrome NOT RCT, given to all
Attention Deficient Hyperactivity Disorder	T	Reduced Reduced	RCT  3,000 IU for 12 weeks RCT  50,000 IU weekly
Alcoholic liver cirrhosis	T	improved survival	1,000 IU of vitamin D NOT RCT
Diabetic nephropathy	T	Reduced HOMA-IR, FRS	RCT 50,000 IU weekly
Ulcerative Colitis	T	Reduced 60%	RCT 50,000 IU nano daily for a week
Obese weight loss	T	Lost 3X more pounds	$10 of Vitamin D added to   calorie restriction & walking
Endometriosis	T	Nicely treated	RCT  50.000 IU bi-weekly
Diabetic Wounds	T	4X more likely to heal	RCT  6,400 daily
Alzheimer's	T	Often reverse	Each person gets a different amount of Vit D, Omega-3, B12, Iron, etc
Autoimmune	P	Decrease 30%	RCT  Vit D + Omega-3
Smoking	T	reduce problems	RCT  50,000 bi-weekly

Most proofs are RCT (Randomized Controlled Trials), where not even the doctor knows who gets it vitamin D

• 2 are meta-analysis of multiple RCTs
• Vitamin D was given to ALL infants in the entire country (Rickets) - not an RCT
• In several studies researchers felt that it was unethical to not give vitamin D to everyone
• In some studies the dose size varied with the needs of the person (overweight, etc)
• In some studies the COFACTORS were adjusted with the needs of the patient%
  • Curing requires the dose size and cofactors to be adjusted to the needs of each patient.

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Many Clinical Trials have not found a benefit because of one or more of the following failures:

1. Fails to use a large enough dose of vitamin D (often < 1,100 IU)
   The Even larger dose needed if: 1) obese, 2) poor gut, 3) sick (many diseases consume lots of vitamin D)
2. Fails to have given vitamin D for a long enough time (a few RCT lasted less than 5 weeks)
3. Fails to have given Vitamin D frequently enough. At least every 2 months for D3) - and at least weekly for D2
   Note: Infrequent dosing also causes unbalancing of the body's chemistry
4. Fails to provide a loading dose, or had too short a duration to restore the vitamin D levels
5. Fails to use D3 form, instead uses the less effective D2 form
6. Fails to have a healthy range of Calcium or other important cofactors (especially for bone-related trials
   Also, differences in Magnesium can result in 30% change in response to vitamin D
   Magnesium is dependent on water, food, supplements
7. Fails to notice the pre-existing vitamin D levels - only those who are low will likely show a benefit
8. Fails to notice how/when the vitamin D was taken (which can change the response by as much as 2X)
9. Fails to report on compliance (in one case 40% of the participants did not take the supplements consistently)

Many Meta-Analyses also do not find a benefit because one or more of the above failures
In addition, many meta-analysis average together ALL of the trials
Imagine a story about a meta-analysis of aspirin (which has never been done)
   There would be scores of RCT for aspirin not working with 3 mg doses
   There would be a many RCT of aspirin not working with 30 mg doses
   There would be a few studies of aspirin WORKING with 300+ mg doses
   There would be many studies of small amounts of Willow bark (Vitamin D2 instead of Vitamin D3)
   Then there would be a meta-analysis of aspirin and Willow Bark
   - That meta-analysis would conclude that aspirin and Willow bark do not work.

While about 200 RCTs will be published during 2014, I anticipate only adding 50 to the proofs table due to the reasons listed above
   Also, some trials will not get started due to lack of people willing to go for years with < 500 IU of vitamin D

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See also VitaminDWiki: Random Controlled Trials with vitamin D  intervention

• Intervention - Vitamin D 763 Interventions
  • Note: It sorts the interventions by health problem as well as by date
• Vitamin D intervention trials - a long list - May 2014 1204 trials
  2176 Vitamin D clinical trials as of June 2020: Nutrition Disorders 621, Vitamin D Deficiency 619, Malnutrition 601, Avitaminosis 586, Deficiency Diseases 583, **Metabolic Diseases 489. Musculoskeletal Diseases 362, Bone Diseases 317. Bone Diseases, Metabolic 282, Endocrine System Diseases 241. Osteoporosis 209, Immune System Diseases 190, Kidney Diseases 168, Communicable Diseases 164. Infection 164
  • Update Nov 2022   2643 Clinical Trials with Vitamin D
• Systematic Reviews or Meta-Analysis of Vitamin D 593 items
• 137 health problems associated with low vitamin D – meta-meta-analysis April 2014
• Intervention - 2-30 days 240 items

More intervention trials for Vitamin D than for the TOTAL of Vitamins A + C + K combined

Vitamin D = 2199, Others = 1803 Vitamin A 702 + Vitamin C 768 + Vitamin K 333    as of Aug 2020

See also VitaminDWiki

• Overview: Vitamin D also TREATS
• Is it ethical to not give vitamin D in osteoporosis trials– NEJM Sept 2010
  • Some Vitamin D RCT are not being created because the researchers do not want to deprive the benefits to half of the patients
  • Some Vitamin D RCT cannot be started because too many candidates are already taking vitamin D
• Reasons for Vitamin D deficiency
• List of all categories of Vitamin D Information and number of items in each
• List of all Overviews of Vitamin D 76 items along with related searches

CLICK ON chart for more information and translation

Vitamin D is especially needed during pregnancy

Problem	Reduces	Evidence
0. Chance of not conceiving	3.4 times	Observe
1. Miscarriage	2.5 times	Observe
2. Pre-eclampsia	3.6 times	RCT
3. Gestational Diabetes	3 times	RCT
4. Good 2nd trimester sleep quality	3.5 times	Observe
5. Premature birth	2 times	RCT
6. C-section - unplanned	1.6 times	Observe
Stillbirth - OMEGA-3	4 times	RCT - Omega-3
7. Depression AFTER pregnancy	1.4 times	RCT
8. Small for Gestational Age	1.6 times	meta-analysis
9. Infant height, weight, head size      within normal limits		RCT
10. Childhood Wheezing	1.3 times	RCT
11. Additional child is Autistic	4 times	Intervention
12.Young adult Multiple Sclerosis	1.9 times	Observe
13. Preeclampsia in young adult	3.5 times	RCT
14. Good motor skills @ age 3	1.4 times	Observe
15. Childhood Mite allergy	5 times	RCT
16. Childhood Respiratory Tract visits	2.5 times	RCT

RCT = Randomized Controlled Trial

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Also, The Vitamin D Receptor limits the amount of Vitamin D in the blood actually gets to the tissue

The risk of 45 diseases at least double with poor Vitamin D Receptor as of Nov 2022

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Want a LOT more data on Vitamin D treating early COVID or preventing health problems

1. China provides an opportunity to give Vitamin D to 1,000's who have either tested positive or have been near someone who has tested positive
2. Saudi Arabia might provide the funds to give vitamin D to everyone in a small city and record how many fewer medical visits there were later
   Note: A previous informal study causes us to guess there will be a 2X reduction in all medical visits.

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Saudi Arabia is funding longevity etc - but I got many negative comments about helpint them

Getting data on results of intervention

Might be able to access Medical Records - at least # of doctors' visits

• Electronic medical records and health care promotion in Saudi Arabia - 2020  PDF
• Performance, Barriers, and Satisfaction of Healthcare Workers Toward Electronic Medical Records in Saudi Arabia: A National Multicenter Study - Feb 2022  PDF
• Exploring Facilitators to the Implementation of Electronic Health Records in Saudi Arabia - March 2022  PDF

On the Large Scale Plans of the Hevolution Foundation - June 2022

Fighting Aging.org
Anyone who has more money than they know what to do with eventually tries to cure aging. Google founder Larry Page has tried it. Jeff Bezos has tried it. Tech billionaires Larry Ellison and Peter Thiel have tried it. Now the kingdom of Saudi Arabia, which has about as much money as all of them put together, is going to try it. The Saudi royal family has started a not-for-profit organization called the Hevolution Foundation that plans to spend up to $1 billion a year of its oil wealth supporting basic research on the biology of aging and finding ways to extend the number of years people live in good health, a concept known as "health span."

The foundation hasn't yet made a formal announcement, but the scope of its effort has been outlined at scientific meetings and is the subject of excited chatter among aging researchers, who hope it will underwrite large human studies of potential anti-aging drugs. The idea, popular among some longevity scientists, is that if you can slow the body's aging process, you can delay the onset of multiple diseases and extend the healthy years people are able to enjoy as they grow older. The fund is going to give grants for basic scientific research on what causes aging, just as others have done, but it also plans to go a step further by supporting drug studies, including trials of "treatments that are patent expired or never got commercialized."

The fund is authorized to spend up to $1 billion per year indefinitely, and will be able to take financial stakes in biotech companies. By comparison, the division of the US National Institute on Aging that supports basic research on the biology of aging spends about $325 million a year. Hevolution hasn't announced what projects it will back, but people familiar with the group say it looked at funding a $100 million X Prize for age reversal technology and has reached a preliminary agreement to fund the TAME trial, a test of the diabetes drug metformin in several thousand elderly people.

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Health + Evolution = hevolution

• "We believe every human has the right to live a longer, healthier life"
• "Every person should live better – not just longer. This purpose can, with the right incentives from Hevolution, bring together the brightest and best scientific and business talent worldwide to reshape age in terms of opportunity, not decline."

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Dr. Mehmood Khan Chief Executive Officer Hevolution Foundation

I was given an outstanding opportunity to build Hevolution Foundation, a pioneering new organization with a laser-like focus on dramatically improving a condition that affects every human on the planet: aging.

Our mission is to drive efforts to extend healthy human lifespan, or healthspan, and to better understand the processes of aging, because the simple truth is: we all age; but we do not all age equally.

As a scientist, physician, and human being, I have seen that the experience of aging is not sufficiently improving. The number of individuals with chronic diseases has increased, despite average lifespan lengthening. We live longer, but we do not necessarily live better. As the world population grows, the population of the elderly grows as well, leading to non-communicable diseases (NCDs) becoming the leading cause of death worldwide. As such, aging is the second most pressing challenge facing humanity after climate change.

Hevolution Foundation is the first non-profit to pursue age-related therapeutic breakthroughs with a commitment to funding global scientific discovery, and investing in private companies and entrepreneurs who are dedicated to advancing aging science. Through the acceleration of science, we can decelerate aging and its consequences.

Changing Accepted Views
The world doesn’t yet see aging as a treatable medical, scientific, and biological condition. We’ve been encouraged to accept that aging means decline. Changing this view is our opportunity to transform the acceptance of age-related health decline into a courageous drive to put world-class resources and talent toward extending healthspan.
We must move from reactive amelioration to proactive prevention. We must engage not only individual scientists and entrepreneurs, but also private and public sector organizations and institutions worldwide. Finally, we must work across geographies and disciplines in a way that is equitable, scalable, and responsible.

Building New Incentives
To encourage the best and brightest talent, we need a genuine, independent and global set of incentives for researchers, academic institutions, professional organizations, entrepreneurs and governments. Our day-to-day work is in building, promoting, and protecting these incentives.

Lessons of COVID
COVID-19 revealed that the elderly, especially those with pre-existing chronic conditions, are among the most vulnerable and at risk in society. However, it also demonstrated that with alignment and incentives, scientists can achieve medical breakthroughs that were previously thought impossible.

To mobilize great talent, we need the same razor-sharp focus, discipline and support for new approaches and therapies.

A Transparent Global Organization
Hevolution was founded to make these great leaps forward possible. As a non-profit organization devoted to collaboration and sharing information, we seek to democratize science and knowledge, by creating partnerships, offering grants, and making investments in the longevity space.

Our highly experienced management team is assembling a staff of elite scientists, clinicians, grant experts and investment professionals, and is guided by a Board of Trustees and advisory panels comprising thought-leaders from all over the world.

We are dedicated to supporting cutting-edge, peer-reviewed science, particularly applied research, focused on accelerating therapeutic approaches to aging, including drug discovery and delivery in key areas of biology that underpin aging. We are able to fund science to a larger scale and with longer investment horizons than traditional venture capital, and with a more commercial mindset than traditional academic research.

Balancing Funding, Scientific Integrity, and Regional Priorities.
Our initial funding comes from a variety of donors, including the government of Saudi Arabia. Our annual budget of up to $1 billion USD enables us to accelerate science and bring therapies to the market.

We aim to work closely with global entities and research centres that share the same mission and objectives.

Global success depends upon global collaboration, which lies at the heart of our mandate.
There is evidence that Gulf Cooperation Council (GCC) populations are aging faster biologically than they are chronologically. Despite the region having one of the youngest populations in the world, its people are experiencing higher mortality from chronic conditions like heart disease and diabetes. Hevolution’s goal is healthspan equity and we will devote the resources needed to achieve it. This region, with its history of generating founding principles in science and medicine, yet suffering from significant age-related risks, presents a strong case to be the catalyst for healthspan transformation worldwide.

Giving Aging a Better Future
Today marks a hugely exciting milestone for our global team which has worked tirelessly and quietly to create a Foundation that will enable and catalyze the field of geroscience.

I am thrilled to lead this visionary organization, at the start of a monumental effort to give aging a better future.

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Dr. Khan's background

From NIST

• CEO Hevolution Foundation
• CEO and Board Member. Life Biosciences was founded to advance scientific research and develop innovative new therapies to improve and extend healthy lives for everyone.
• Vice Chairman and Chief Scientific Officer of Global Research and Development at PepsiCo
  • https://www.tedmed.com/talks/show?id=69532011 TedTalk
• Dr. Khan had a distinguished medical career as a faculty member in endocrinology at the Mayo Clinic and Mayo Medical School where he served as Director of the Diabetes, Endocrine and Nutritional Trials Unit. He also spent nine years leading programs in diabetes, endocrinology, metabolism and nutrition in Minneapolis, MN.

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VitaminDWiki pages with SAUDI in the title (18 as of July 2022)

This list is automatically updated

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VitaminDWiki - Middle East and Vitamin D contains

149 items in Middle East category

see also Overview Middle East and vitamin D

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VitaminDWiki - Longevity

• Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
• Top 10 causes of death - low vitamin D is associated with every cause - Nov 2018
• Vitamin D - at least 4,000 IU to achieve 40-60 ng and reduce risk of early death – Holick June 2018
• Top 10 causes of death - low vitamin D is associated with every cause - Nov 2018
• 2,000 IU of Vitamin D daily to German Seniors would save 30,000 lives a year – March 2021

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China summary: Sent 6 letters to Dr. Shen but got Zero response. so I gave up

3 in English, 3 translated to Chinese by Google Translate
 English PDF
 Chinese PDF

China's Zero COVID policy: the best tracking data on the planet

Some publicatons by Hong-bing Shen

• Plasma vitamin D levels and vitamin D receptor polymorphisms are associated with survival of non-small cell lung cancer - 2011 corresponding author  PDF
• Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in a Large Cohort: Results From the UK Biobank - OCT 2020  Low Mortality if more than 20 ng of Vitamin D (UK Biobank) – Oct 2020
• Genome-wide association study (GWAS) and risk prediction of complex disease: advances and prospects Chinese - July 2011
• Basic reproduction number and predicted trends of coronavirus disease 2019 epidemic in the mainland of China - July 2020  PDF
• Advances in applications of polygenic risk score in precision prevention - Oct 2021  Chinese PDF  English PDF

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Quarantine time and locations changed June 29, 2022

How China’s COVID Quarantine Rules Have Evolved

Just the cost of testing: >$34 Billion for 2022

China’s Regular Covid Testing to Cost 1.8% of GDP, Nomura Says

• Bloomberg if done widely in China
• " If China’s wealthiest cities, home to 30% of its population, introduced regular mass testing, the costs could amount to 0.2% of GDP over the second half of this year, "
• China GDP = 17,000 Billion dollars
• 0.2 % of China's GDP = $34 billion dollars

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