Poor Ischemic stroke outcome (END) 2.6 X worse if low vitamin D – March 2019

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Decreasing serum 25-hydroxyvitamin D levels and risk of early neurological deterioration in patients with ischemic stroke.

Brain Behav. 2019 Mar;9(3):e01227. doi: 10.1002/brb3.1227
Hu W1, Liu D2, Li Q3, Wang L1, Tang Q1, Wang G1.

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BACKGROUND AND AIMS:
Vitamin D deficiency has been linked to a higher risk of ischemic stroke. We therefore explored the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and early neurological deterioration (END) after acute ischemic stroke in a hospital-based prospective study.

METHODS:
From June 2016 to June 2018, patients with ischemic stroke within 48 hr from symptom onset were consecutively recruited. Serum 25(OH)D levels were measured at admission.
END was defined as an increase of

• ≥1 point in motor power or
• ≥2 points in the total National Institute of Health Stroke Scale score within 7 days after admission.

Multiple logistic regression models were performed to calculate the odds ratio (OR) and confidence intervals (CI) of 25(OH)D levels in predicting END.

RESULTS:
A total of 478 subjects were enrolled, of which 136 (28.5%) patients developed END. The mean 25(OH)D levels were 49.5 ± 15.8 nmol/L. Univariate logistic regression analysis showed that advanced age, white matter lesions, high level of body mass index, diastolic blood pressure, fasting blood glucose and homocysteine, and low 25(OH)D levels were associated with END. Furthermore, multivariate regression analysis demonstrated that the first quartile of 25(OH)D concentrations [OR, 2.628; 95% CI,1.223-5.644; p = 0.013] was independently risk factor for END.

CONCLUSIONS:
This study illustrated that lower 25(OH)D levels might be associated with an increasing risk of END in acute ischemic stroke patients.

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VitaminDWiki – Stroke category contains

122 items in stroke category - see also Overview Stroke and vitamin D,
Overview Hypertension and Vitamin D  Overview Cardiovascular and vitamin D

Stroke more likely if low Vitamin D

• Stroke 74% less likely if high vitamin D (7,295 women 20-50 years old) – July 2017
• Stroke is 13.5 X more likely if low vitamin D and high blood pressure – March 2015
• Ischemic stroke 17 X more likely if low vitamin D – April 2017
• Stroke is strongly associated with Calcification of cerebral arteries (perhaps low Vitamin D, Vitamin K, Mg…) – March 2018
• Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014

Post-Stroke worse if low Vitamin D

• Poor Acute Ischemic Stroke 4X more likely if low Vitamin D - Nov 2023
• Stroke risks increased if low Vitamin D: Death 3.6 X, recurrence 5.5 X – Meta-analysis Nov 2019
• Stroke outcome at 3 months was 3X worse if bad stroke and low vitamin D – Jan 2020
• Death after Ischemic Stroke 2.5 X more likely if less than 10 ng of Vitamin D – May 2019
• Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015
• Depression following a stroke is 2.7 X more likely if low vitamin D – Sept 2018
• Stroke incidence not associated with low Vitamin D (but stroke outcome is) – Aug 2019

Post-Stroke better if add Vitamin D

• Post-stroke Vitamin D supplementation helped in 11 ways – May 2023
• Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018
• Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017
• Ischaemic stroke – Vitamin D doubled survival (Injection followed by monthly 60,000 IU) – RCT Aug 2016
• Stroke patients need more than 2,000 IU of vitamin D (found this time in Japan) – RCT June 2019

Post-Stroke better if Vitamin D actually gets to cells

• Resveratrol fights Parkinson, Alzheimers, Diabetes, Cardiovascular, ALS, Stroke, etc.– Nov 2018
• Stroke rehabilitation (and prevention) requires Vitamin D actually getting to cells – March 2020

9 studies in both categories Depression and Stroke

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Items in BOTH of the categories Intervention and Stroke:

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23+ VitaminDWiki Stroke pages have ISCHEMIC OR ISCHAEMIC in the title

This list is automatically updated